Immunoglobulins Level in Patients Suffering from Major Depressive Disorder (MDD) in Comparison with Normal Healthy Individuals: A Prospective Study

B cells and the stressed brain: emerging evidence of neuroimmune interactions in the context of psychosocial stress and major depression

“…Methodological differences between sample populations and measurement approaches may account for some of the discrepancy between these studies, though recent meta-analyses confirmed that acute stress elevated Ig levels while chronically stressed humans showed age-related increased IgA or decreased IgM ( Khan et al, 2021 ; Castro-Quintas et al, 2023 ). Mainly implicated in response to allergens, serum IgE levels are elevated in MDD patients ( El-Ansary, 2022 ) and hydrocortisone increased IgE levels in IL-4 stimulated human lymphocytes ( Wu et al, 1991 ). Though one study noted elevated IgD levels among MDD patients ( El-Ansary, 2022 ), very little is known about how psychosocial stress or MDD impact IgD, likely due to its very low level of basal expression ( Vladutiu, 2000 ).…”

“…Mainly implicated in response to allergens, serum IgE levels are elevated in MDD patients ( El-Ansary, 2022 ) and hydrocortisone increased IgE levels in IL-4 stimulated human lymphocytes ( Wu et al, 1991 ). Though one study noted elevated IgD levels among MDD patients ( El-Ansary, 2022 ), very little is known about how psychosocial stress or MDD impact IgD, likely due to its very low level of basal expression ( Vladutiu, 2000 ). In mice, elevated platform stress-induced B cell profile shifts corresponded to an increase in IgG antibody titers in blood in the weeks following the stress exposure ( Zhang et al, 2020 ).…”