Immunoglobulins in Multiple Sclerosis and Infections of the Nervous System

B cells in multiple sclerosis

“…In addition, the anti-CNP1 activity, defined as the amount of CNP1 that co-purified with CSF antibody, was compared only to MBP that copurified with CSF Ig and not to the entire mixture of purified antigens, questioning whether CNP1 is the most prevalent antigen. Further, no IgG response to CNP1 was found, although IgG comprises the major oligoclonal response in MS CSF (67,68). Warren et al (50), using solid-phase radioimmunoassay (RIA) to examine the antibody response in CSF to the most abundant myelin component, proteolipid protein (PLP), detected anti-PLP reactivity in CSF from 9 of 385 patients with MS (2%), compared to 6 of 55 (11%) patients with optic neuritis, and no other control patients were tested.…”

Cytological and immunological examination of cerebrospinal fluid in 9 patients with ramsay hunt's syndrome.

“…In a study of viral meningitis, Kalder and Ferris (1969) found increased IgG and IgA concentrations in CSF at about 4 days from onset. In addition, Link and Muller (1971) reported increased IgG percentage, and increased IgG percentage and IgA percentage were described by Schneck and Claman (1969). Based upon the results of serum immunoglobulin and CSF immunoglobulin studies, Takase (1975), one of the present authors, has made a classification of neurological diseases.…”

The Value of Oligoclonal Bands in Neurobrucellosis

“…It has been observed in parasitic, bacterial, viral, and fungal infections and in noninfective disorders such as multiple sclerosis [5,6]. However, the CSF electrophoretic patterns in these diseases are quite different due to variable degrees of breakdown of the blood-CSF barrier as a consequence of the inflammatory process.…”