The Value of Oligoclonal Bands in Neurobrucellosis

Daif, Abdul Kader

doi:10.5144/0256-4947.1991.411

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Other diagnostic methods such as CSF metagenomic next-generation sequencing (mNGS) and 16 s rRNA sequencing technique are also used in diagnosing neurobrucellosis [ 17 ]; however, they are rarely available in the endemic areas. Although other nonspecific CSF parameters such as CSF oligoclonal bands have also been introduced as rapid and useful diagnostic tools, information regarding the value of these tests in confirmation of diagnosis of neurobrucellosis is limited [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Neurobrucellosis: report of 54 cases

et al. 2022

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Background Brucellosis is among the most widespread zoonotic diseases worldwide. Although rare, nervous system involvement due to Brucella infection is a major diagnostic challenge in endemic regions. Patients and methods This study was a cross-sectional investigation of hospitalized adults with neurobrucellosis from March 2007 to February 2017. We described the clinical characteristics, radiographical and laboratory features, and clinical outcomes of patients with neurobrucellosis. Results Fifty-four patients with neurobrucellosis were included. The median age was 35 (interquartile range, 25–50) years, and 32 (59%) cases were male. Thirty-four (63%) patients were stockmen or shepherds. The most common clinical manifestations were fever in 49 (91%) cases, headache in 47 (87%), decreased consciousness in 12 (22%), and seizures in 6 (11%). Meningeal signs were detected in 36 (67%) cases. Brucella species were isolated in five cases from blood or cerebrospinal fluid (CSF). The median of CSF leukocytes was 75 per µL, CSF protein 83 mg/dL, and CSF glucose 39 mg/dL. Only two cases had severe hypoglycorrhachia and one CSF protein ≥ 500 mg/dL. No patient died during hospitalization. Conclusions The symptoms of neurobrucellosis could be mild and nonspecific and the classic triad of meningitis is uncommon. Mild CSF pleocytosis of fewer than 50 leukocytes per microliter of CSF was common but severe hyperproteinorrhachia and severe hypoglycorrhachia were rare in neurobrucellosis. Differentiation between neurobrucellosis and systemic brucellosis is important, because more prolonged treatment is indicated for neurobrucellosis, and it could be associated with a broad spectrum of complications that require close follow-up.

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Section: Introductionmentioning

confidence: 99%

Neurobrucellosis: report of 54 cases

et al. 2022

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“…At least 3 such lesions must be present with one of them located in the periventricular region for the diagnosis to be made [13][14][15]. The method used for detecting oligoclonal bands and the sensitivity in our laboratory had been described previously [16].…”

Section: Methodsmentioning

confidence: 99%

Pattern of Presentation of Multiple Sclerosis in Saudi Arabia: Analysis Based on Clinical and Paraclinical Features

et al. 1998

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We studied 89 MS patients comprising 38 males and 51 females seen over a 10-year period. The hospital frequency was 25/100,000 patients. The diagnosis was mainly clinical and was supported by neuroimaging, cerebrospinal fluid analysis and neurophysiological tests. Sixty-five patients (73%) were Saudis and the peak age of onset was in the third decade. Fifty-two patients (58.4%) had clinically definite MS, 17 (19.1%) had laboratory-supported definite MS, 15 (16.9%) were clinically probable MS cases and the remaining 5 (5.6%) had laboratory-supported probable MS. The mean age at onset of Saudi patients (25.9 years) was lower than that of the non-Saudis (29.4 years; p < 0.001). Involvement of the pyramidal system was the commonest mode of presentation. The clinical course was relapsing-remitting in 60.7%, progressive-relapsing in 20.2% and primary progressive in 19.1%. The number of systems involved was significantly associated with the duration of disease (p < 0.001). The demographic features and the variability of clinical presentation of Saudi MS patients is similar to the results from neighbouring countries. Combination of clinical features and paraclinical tests is essential for accurate determination of extent of dissemination and for unmasking clinically silent lesions.

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“…Due to the absence of distinctive clinical features, misdiagnosis with other infections is common. The diagnostic criteria for neurobrucellosis include cerebrospinal fluid (CSF) agglutination test, enzyme-linked immunosorbent assay (ELLSA), 16s rRNA sequencing and the presence of positive CSF oligoclonal bands [ 1 – 3 ]. However, establishing a diagnosis can be challenging due to potential false-negative results in immunological testing.…”

Section: Introductionmentioning

confidence: 99%

A comparison of clinical features between neurobrucellosis and tuberculous meningitis

Zou,

Wang,

et al. 2024

BMC Neurol

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Backgroud This study aims to compare the clinical manifestations, imaging findings, routine tests, biochemistry indicators and cerebrospinal fluid cytology between neurobrucellosis and tuberculous meningitis. The objective is to evaluate the similarities and differences of these two diseases and improve early diagnosis. Methods A comprehensive evaluation was conducted by comparing clinical data, imaging results, routine tests findings, biochemistry indicators and cerebrospinal fluid cytology of patients admitted to the Department of Neurology, the Second Hospital of Hebei Medical University from 2019 to 2021. Statistical analysis was applied to identify significant differences and similarities between the two diseases. Results Preliminary analysis demonstrated both diseases commonly present with symptoms such as fever, headache. However, there were no statistical differences between neurobrucellosis and tuberculous meningitis in early clinical data, imaging results, routine tests findings, biochemistry indicators. Further analysis indicates there is a statistically significantly difference in the lymphocyte ratio and neutrophil ratio in the cerebrospinal fluid between the two groups. Conclusions Neurobrucellosis and tuberculous meningitis share similarities in early clinical manifestations, imaging findings and initial cerebrospinal fluid parametes, making early-stage differentiation challenging. The ratio of lymphocytes and neutrophil in the cerebrospinal fluid and a detailed medical history investigation can provide clues for early clinical diagnosis. So the examination of CSF cytology might be a potential to distinguish these two diseases and become a powerful tool in the future.

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The Value of Oligoclonal Bands in Neurobrucellosis

Cited by 6 publications

References 9 publications

Neurobrucellosis: report of 54 cases

Neurobrucellosis: report of 54 cases

Pattern of Presentation of Multiple Sclerosis in Saudi Arabia: Analysis Based on Clinical and Paraclinical Features

A comparison of clinical features between neurobrucellosis and tuberculous meningitis

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