Immunoglobulins A, G, and M in synovial fluid in rheumatoid arthritis. Reactive synovitis of local origin and in post mortem synovial fluid.

Hrncír, Z; Tichý, M.; Salavec, M; Vavrina, J

doi:10.1136/ard.31.4.325

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…This was also noted previously by Hollingsworth, Siegel, and Cressey (14), who found the percentage of PMN to be as high in the synovial fluid of factor-negative patients as in those patients in whom rheumatoid factor is present. In addition, it has been shown that the IgG concentration in synovial fluids from these two groups is similar and indeed higher than in any other form of arthritis (13,15). Smiley, Sachs, and Ziff (16) found the major immunoglobulin produced by explants from synovial tissue was IgG.…”

Section: Discussionmentioning

confidence: 93%

The Roles of IgG, IgM Rheumatoid Factor, and their Complexes in the Induction of Polymorphonuclear Leukocyte Chemotactic Factor from Complement

Wagner¹,

Abraham²,

Baum³

1974

J. Clin. Invest.

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A B S T R A C T The induction of chemotactic factor by rheumatoid factor (RF) and by rheumatoid complexes and their constituents was investigated. The presence of chemotactic factor was measured by the number of polymorphonuclear leukocytes (obtained from normal individuals) attracted through a 3 Am Millipore filter and is expressed as a "chemotactic index." The chemotactic index was used to measure the effect of immunoglobulins and their complexes in stimulating production of complement-derived chemotactic factors from the sera of normal individuals.Two sources of IgG (F-II and DEAE-purified IgG) were used. These were prepared for use in the native and heat-aggregated states. The same chemotactic index was obtained with both these preparations of IgG. The chemotactic index increases when (a) increasing concentrations of gamma globulin were added to a constant concentration of complement and (b) when the amount of complement alone was increased.The addition of a purified IgM RF to the mixture of IgG and complement caused a decrease in the chemotactic index. Incubation of IgG and complement before addition of IgM RF produced no change in the chemotactic index. The addition of a nonrheumatoid factor IgM to IgM and complement had no effect on the chemotactic index. IgM RF and IgG alone were not chemotactic.These studies confirm the concept of "complement deviation" by IgM RF which occurs with, and as a result

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Section: Discussionmentioning

confidence: 93%

The Roles of IgG, IgM Rheumatoid Factor, and their Complexes in the Induction of Polymorphonuclear Leukocyte Chemotactic Factor from Complement

Wagner¹,

Abraham²,

Baum³

1974

J. Clin. Invest.

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“…It would be both impractical and unethical to attempt to replicate such a prospective study using synovial fluid, but we are mindful that the site of inflammation is within the joint. Synovial fluid and serum represent two different compartments, with limited exchange between them and levels of IgG, IgM, or IgA in normal synovial fluids are a fraction of the levels in serum [73,74]. As each of the autoantibodies we have studied has been shown to be produced locally within the joint and is more abundant at the site of inflammation and damage, measurements of serum autoantibodies may be misleading and represent only a ‘spill-over’ from the site of the lesion in the joint.…”

Section: Discussionmentioning

confidence: 99%

Collagen Autoantibodies and Their Relationship to CCP Antibodies and Rheumatoid Factor in the Progression of Early Rheumatoid Arthritis

2017

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Serum autoantibodies to cyclic citrullinated peptides (anti-CCP) and rheumatoid factor (RF) are important markers for diagnosis and prognosis of rheumatoid arthritis (RA), but their autoantigens are not cartilage-specific. Autoantibodies to joint-specific type II collagen (CII) also occur in RA, and monoclonal antibodies of similar specificity induce collagen antibody-induced arthritis in animals, but their role in RA is uncertain. We utilized an enzyme-linked immunosorbent assay (ELISA) with the CB10 peptide of CII to compare the frequency of autoantibodies with those of anti-CCP and RF in stored sera from a prospective study of 82 patients with early RA to examine the outcome, defined as remission (n = 23), persisting non-erosive arthritis (n = 27), or erosions (n = 32). Initial frequencies of anti-CB10, anti-CCP and RF were 76%, 54%, and 57% in RA, and 4%, 0%, and 9% in 136 controls. The frequency of anti-CB10 was unrelated to outcome, but anti-CCP and RF increased with increasing severity, and the number of autoantibodies mirrored the severity. We suggest RA is an immune complex-mediated arthritis in which the three antibodies interact, with anti-CII inducing localized cartilage damage and inflammation resulting in citrullination of joint proteins, neoepitope formation, and a strong anti-CCP response in genetically-susceptible subjects, all amplified and modified by RF.

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Supplement: 21st rheumatism review

1974

Arthritis & Rheumatism

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Immunoglobulins A, G, and M in synovial fluid in rheumatoid arthritis. Reactive synovitis of local origin and in post mortem synovial fluid.

Cited by 10 publications

References 13 publications

The Roles of IgG, IgM Rheumatoid Factor, and their Complexes in the Induction of Polymorphonuclear Leukocyte Chemotactic Factor from Complement

The Roles of IgG, IgM Rheumatoid Factor, and their Complexes in the Induction of Polymorphonuclear Leukocyte Chemotactic Factor from Complement

Collagen Autoantibodies and Their Relationship to CCP Antibodies and Rheumatoid Factor in the Progression of Early Rheumatoid Arthritis

Supplement: 21st rheumatism review

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