Immunoglobulin subgroups in children with febrile seizures

Çaksen, Hüseyîn; Öner, Ahmet Faik; Arslan, Şükrü; Kan, Muhİttİn Cengİz; Cesur, Yaşar; Üner, Abdurrahman

doi:10.1046/j.1442-200x.2001.01325.x

Cited by 14 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Iron deficiency anemia has been found to be commoner in children with FC than controls and may also be related to FC (25). Çaksen et al (26) have reported an immunoglobulin deficiency in FC, which may be of significance in causing of FC or the fever. Others have reported a possible immunological derangement in the cytokines and interferon axis in FC that may correlate with the pathogenesis of FC or at the fever (10)(11)(12).…”

Section: Etiologymentioning

confidence: 99%

Febrile convulsion: review and update

Daoud

2015

J Pediatr Neurol

View full text Add to dashboard Cite

Febrile convulsions (FCs) are the most frequently occurring epilepsy syndrome experienced in infants/children between 6 months and 6 years of age and occur in 2?4%. It describes any seizure that occurs in response to a febrile stimulus in the absence of meningitis, encephalitis, serum electrolyte imbalance and other acute neurologic illnesses. There have been many recent reports on the molecular genetic and pathogenesis of FC. It has been recognized that there is significant genetic component for susceptibility of FC with different reported mutation. Others have tried to correlate FC to immunologic problem through interleukin, cytokines, immunoglobulin and interferon. Also, reports on correlations between FC and iron deficiency anemia, hypozincemia or to specific infections have been published. Children having first or second degree relatives with a history of FC, neonatal nursery stay of more than 30 days, developmental delay or attendance at a day care center are at increase risk of developing FC. A single simple FC does not seem to increase the risk of epilepsy and there is no causal relationship between FC and subsequent epilepsy. Viruses are the most common cause of illness in children admitted to the hospital with a first FC. Routine laboratory studies, electroencephalogram and neuroimaging are not indicated for patients who have FC, and should be performed only as part of the evaluation for a source of fever and/or in atypical cases. Prognosis is generally good and parents should be counseled about the benign nature of FC. Children with FC are at no greater risk of intellectual impairments than their peers. Maintenance therapy to prevent recurrence has not been shown to prevent later development of epilepsy, and therefore intermittent diazepam or lorazepam are the main drugs to be used. (J Pediatr Neurol 2004; 2(1): 9?14).

show abstract

Section: Etiologymentioning

confidence: 99%

Febrile convulsion: review and update

Daoud

2015

J Pediatr Neurol

View full text Add to dashboard Cite

show abstract

“…IgA level was lower in SFS patients. Considering the type of seizures, a statistically significantly lower IgG level in FT SFS patients was noted, as compared to CG (20,21,24,28) . Ig levels in GE were higher than in CG, with a visible impact of past infections.…”

Section: Discussionmentioning

confidence: 82%

“…The IgG and IgM levels were lower, whereas the levels of IgA and IgE were higher (not statistically significant). According to their findings, IgG2 and IgG4 deficiencies may account for frequent infections associated with FS, or may be involved in FS pathogenesis in some patients (20) . Eeg-Olofsson et al investigated serum IgG, IgA, IgM and CSF levels in children following FS.…”

Section: Discussionmentioning

confidence: 99%

“…According to the sources, immunoglobulin (Ig) deficiencies -IgG, IgA, IgM, and IgG2, IgG4 subclasses -contribute to the pathogenesis of FS. Abnormal Ig levels may increase susceptibility to infection or, in some cases, may be involved in FS pathogenesis (10,(16)(17)(18)(19)(20)(21) . Zubiel et al pointed to the impaired specific humoral immunity in FS patients, particularly those exhibiting single episodes.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Assessment of basic immunological parameters in children with seizure disorders during acute infection

Bugaj,

Mania,

Górna

et al. 2023

Pediatr Med Rodz

View full text Add to dashboard Cite

Introduction and objective: The objective of the study was to assess basic immunological parameters in children presenting with seizure disorders during acute infection. Materials and methods: The study was conducted from 19 January 2017 to 5 December 2020 at the Department of Infectious Diseases and Child Neurology in Poznań, and involved 121 patients aged 5–188 months: 64 with febrile seizures and 11 with generalised epilepsy. The control group comprised 46 patients with delayed psychomotor and intellectual development, pervasive developmental disorders, and neurodeficits. A complete blood count with differential white cell count, inflammatory markers, immunoglobulin classes (IgG, IgA, IgM), and the aetiology of infection were analysed using standard laboratory methods in all the cases. Results: Lower IgG was found in the febrile seizures group, and lower IgA was observed in the simple febrile seizure group compared to the patients after epileptic seizures. Patients with first-time simple febrile seizures showed lower IgG levels than the control group. Patients with generalised epilepsy and human herpesvirus 6 (HHV-6) showed lower IgG than the non-infected subjects. Patients with first-time complex febrile seizures had the lowest lymphocyte count compared to the control group. The lowest neutrophil count and total leukocyte count were found in HHV-6-infected patients with simple febrile seizures compared to the non-infected patients. Conclusions: Monitoring basic haematological parameters and immunoglobulin levels is an effective strategy in the diagnosis of seizure disorders in children. Screening tests provide an initial quantitative assessment of humoral and cellular responses, as well as impaired phagocytosis.

show abstract

“…Çaksen et al 32 have reported an immunoglobulin deficiency in FS, which may be of significance in causing of FS or the fever. Others have reported a possible immunological derangement in the cytokines and interferon axis in FS that may correlate with the pathogenesis of FS or at the fever 32 .…”

Section: Water and Electrolyte Imbalancementioning

confidence: 99%

Etiology and Risk Factors of Febrile Seizure An Update

Kundu

Rabin

et al. 2012

Bangladesh J Child Health

View full text Add to dashboard Cite

Febrile seizures (FS) are the most common convulsive event in children. This condition has been described since the time of Hippocrates. The etiology of the febrile seizures are still unclear. In FS, there is a strong familial predisposition. This does not exclude infections as a causative factor because subtle genetic polymorphisms have been demonstrated to affect the course of infections. In an earlier review of the world literature (1924-1964), except for roseola infantum, viral infections as a cause of febrile seizures were rarely diagnosed. Reports of viral infections in the etiology of febrile seizures have increased in number in the past decade. In the first half of the twentieth century, infections identified with febrile seizures were mainly upper respiratory in type and the etiologic agent was unknown or bacterial. We review i) the role of infection viral and bacterial; ii) the role of genetic and environmental factors; iii) the role of electrolyte and metabolic factors; and iv) the role of cytokines. With the help of new diagnostic tools such as PCR, the viral agents are detected in CSF far more often than previously thought, even in the absence of pleocytosis of the CSF. This makes it difficult to distinguish FS from acute encephalitis. FS may be caused by neuroinvasion or intracerebral activation of viruses. By reviewing etiology and risk factors of FS we can identify the points to be focused in therapeutic interventions and trials and also the fields of future studies will be explored. DOI: http://dx.doi.org/10.3329/bjch.v34i3.10361 BJCH 2010; 34(3): 103-112

show abstract

Immunoglobulin subgroups in children with febrile seizures

Abstract: The results of the present study suggest that Ig subclass deficiencies may be responsible for the infections connected with FS or that they may be related to the pathogenesis of FS in some children.

Cited by 14 publications

References 16 publications

Febrile convulsion: review and update

Febrile convulsion: review and update

Assessment of basic immunological parameters in children with seizure disorders during acute infection

Etiology and Risk Factors of Febrile Seizure An Update

Contact Info

Product

Resources

About

Immunoglobulin subgroups in children with febrile seizures

Abstract: The results of the present study suggest that Ig subclass deficiencies may be responsible for the infections connected with FS or that they may be related to the pathogenesis of FS in some children.

Cited by 14 publications

References 16 publications

Febrile convulsion: review and update

Febrile convulsion: review and update

Assessment of basic immunological parameters in children with seizure disorders during acute infection

Etiology and Risk Factors of Febrile Seizure  An Update

Contact Info

Product

Resources

About

Etiology and Risk Factors of Febrile Seizure An Update