Abstract:Most contacts with food protein and microbiota antigens occur at the level of the gut mucosa. In animal models where this natural stimulation is absent, such as germ-free and antigen-free mice, the gutassociated lymphoid tissue (GALT) and systemic immunological activities are underdeveloped. We have shown that food proteins play a critical role in the full development of the immune system. C57BL/ 6 mice weaned to a diet in which intact proteins are replaced by equivalent amounts of amino acids (Aa diet) have a… Show more
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