Immunoglobulin Nature of PPD Receptors on Human T Lymphocytes

Rajapakse, D. A.; Papamichail, Michael; Holoborow, E. J.

doi:10.1038/newbio245155a0

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1974

1977

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Cited by 7 publications

(1 citation statement)

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“…Another approach used for determining the presence of immunoglobulins on T lymphocytes is the suppression of T-cell function by antiimmunoglobulin serum. Mitogenic responses (25,26), lymphokine production (27), and antigenic recognition (1) have all been shown to be susceptible to such antisera.…”

Section: Introductionmentioning

confidence: 99%

Surface immunoglobulin on activated human peripheral blood thymus-derived cells.

Whiteside¹,

Rabin²

1976

J. Clin. Invest.

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Section: Introductionmentioning

confidence: 99%

Surface immunoglobulin on activated human peripheral blood thymus-derived cells.

Whiteside¹,

Rabin²

1976

J. Clin. Invest.

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Participation of immunoglobulin‐bearing lymphocytes in the production of macrophage migration inhibitory factor

Pick¹,

Godny²,

Gold³

1975

Eur J Immunol

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The role of immunoglobulin-bearing cells in the production of macrophage migration inhibitory factor (MIF) by tuberculin-stimulated lymphocytes of guinea pigs, immunized with complete Freund's adjuvant, was studied. It was found that: (1) pretreatment of lymphocytes with rabbit anti-guinea pig IgG (anti-IgG) does not block antigen-induced MIF production. (2) Passage of lymphocytes through double layer IgG-anti-IgG gelatin bead columns (the preparation of which is described) abolishes MIF formation by the eluted cells. Cells retained on the columns can be recovered and where shown to produce MIF, when stimulated by antigen. (3) Pulsing of lymphocytes with anti-IgG, for 2 h at 37degreesC, results in MIF synthesis by the cells cultured in medium, in the absence of specific antigen. These findings indicate that cells bearing Ig or Ig fragments are either able to secrete MIF themselves, upon stimulation with antigen or anti-IgG, or are required for MIF production by a different cell type.

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Immunologic Considerations

Papaioannou

1974

The Etiology of Human Breast Cancer

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Immunoglobulin Nature of PPD Receptors on Human T Lymphocytes

Cited by 7 publications

References 18 publications

Surface immunoglobulin on activated human peripheral blood thymus-derived cells.

Surface immunoglobulin on activated human peripheral blood thymus-derived cells.

Participation of immunoglobulin‐bearing lymphocytes in the production of macrophage migration inhibitory factor

Immunologic Considerations

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