Immunoglobulin G4-Related Inflammatory Pseudotumor Presenting as a Solitary Mass in the Stomach

Cheong, Hong Ryeol; Lee, Bong Eun; Song, Geun Am; Kim, Gwang Ha; An, Sung Gyu; Lim, Weon Jeong

doi:10.5946/ce.2015.074

Cited by 24 publications

(25 citation statements)

References 14 publications

(15 reference statements)

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“…So far, several reports describing cases with gastrointestinal manifestations have been published (Table 1). However, more than half of them did not have extra gastrointestinal manifestations or serum IgG4 elevation, and were diagnosed based only on the pathological examinations [19][20][21]28]. Baez et al reported a case of autoimmune pancreatitis with wall thickening and nodular lesions in the gastric wall [22].…”

Section: Discussionmentioning

confidence: 99%

“…Although IgG4-RD mainly involves glandular tissues or the vascular system, several case reports have shown that IgG4-RD also involves the gastrointestinal tract with ulcer, polypoid lesions, submucosal mass, and wall thickening. However, because of the small number of reports on the gastrointestinal lesions of IgG4-RD, their entire spectrum has not yet been adequately documented, and especially, the radiological aspects of many of these lesions are still obscure [19][20][21][22][23][24][25][26][27][28]. Here, we report the detailed imaging findings in a case of IgG4-RD with gastric involvement.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Imaging and pathological features of gastric lesion of immunoglobulin G4-related disease: A case report and review of the recent literature

Inoue

Yoneda

Yoshida

et al. 2016

Modern Rheumatology

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We describe a 67-year-old man with immunoglobulin G4-related disease (IgG4-RD) presenting with optic neuropathy, dacryoadenitis, periaortitis, retroperitoneal fibrosis, and a gastric masslike lesion. A mass-like lesion measuring 52 Â 40 mm in the antrum of the stomach was found incidentally through whole-body screening for other organ involvement of IgG4-RD using contrast-enhanced computed tomography (CT). Histology of the stomach revealed that the lesion was also IgG4-related and was located in the submucosal layer extending to the subserosal region. This case suggests that the stomach can also be a site of involvement of IgG4-RD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Imaging and pathological features of gastric lesion of immunoglobulin G4-related disease: A case report and review of the recent literature

Inoue

Yoneda

Yoshida

et al. 2016

Modern Rheumatology

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“…Because this disease involves a submucosal lesion in the stomach, these cases are often misdiagnosed as GIST [3,7,18,19] and are difficult to diagnose on endoscopic forceps biopsy, similar to our cases. Gastric lesions that have been mistaken for GIST or gastric cancer have been reported in the literature (Table 1) [3,[6][7][8][9][10][11][12][13][14][15]. IgG4-RD of the stomach that involved the regional lymph nodes has also been reported [6].…”

Section: Discussionmentioning

confidence: 99%

Gastric IgG4-related disease presenting as a mass lesion and masquerading as a gastrointestinal stromal tumor

Ramakrishna¹,

Yewale²,

Vijayakumar³

et al. 2020

J Pathol Transl Med

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IgG4-related disease of the stomach is a rare disorder, and only a few cases have been reported. We present two cases that were identified over a 2-month period in our center. Two male patients aged 52 and 48 years presented with mass lesion in the stomach, which were clinically thought to be gastrointestinal stromal tumor, and they underwent excision of the lesion. Microscopic examination revealed marked fibrosis, which was storiform in one case, associated with diffuse lymphoplasmacytic infiltration and an increase in IgG4positive plasma cells on immunohistochemistry. Serum IgG4 level was markedly elevated. Although rare, IgG4-related disease should be considered in the differential diagnosis of gastric submucosal mass lesions.

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“…In this condition, levels of serum IgG4 significantly increased. Recently, it's been reported frequently in the stomach, a novel site for this inflammatory pseudotumor subtype [30,34]. IgG4-RDs are often misdiagnosed since the lesions can mimic tumors and might be misinterpreted clinically and radiologically as a neoplasm [4,35].…”

Section: Igg4-related Gastric Tumefactive Lesionsmentioning

confidence: 99%

Immunoglobulin G4-Related Disease Manifesting as Isolated, Typical, and Nontypical Gastroesophageal Lesion: A Research of Literature Review

et al. 2019

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Background: Immunoglobulin G4-related disease (IgG4-RD) is an autoimmune inflammatory and fibrotic condition. The disease is characterized by tissue infiltration with dense lymphoplasmacytes and IgG4-positive plasma cells. Summary: The aim of this study was to provide gastroenterologists with novel insights into evaluating the gastroesophageal involvement with IgG4-RD or mimickers of this condition and to give special attention to clinicopathological features. A literature review was performed using the PubMed database. A total of 39 studies presenting cases in the form of isolated, typical, and nontypical gastroesophageal involvement with IgG4-RD published between 2010 and 2018 were included. These studies were thoroughly reviewed for symptoms, lesion location, lesion type, lesion size, immune-histopathology, associated diseases, treatment, and follow-up. Of the 39 studies reviewed, 9 were esophageal IgG4-RD lesions, isolated esophageal IgG4-RD 66.66% (6/9), a typical form of esophageal IgG4-RD 11.11% (1/9), and nontypical form esophageal IgG4-RD 22.22% (2/9). The 30 gastric IgG4-RD that include isolated gastric IgG4-RD 46.66% (14/30), typical gastric IgG4-RD 40% (12/30), and nontypical gastric IgG4-RD 13.33% (4/30). The majority of lesions were inflammatory tumors, ulceration, nodular lesions, chronic gastritis, and malignant lesions. Key Messages: IgG4-RD may be manifested by isolated, typical and nontypical forms of gastroesophageal lesions and should be taken into consideration in the differential diagnosis. Corticosteroids may be the sole diagnostic treatment for this condition.

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Immunoglobulin G4-Related Inflammatory Pseudotumor Presenting as a Solitary Mass in the Stomach

Cited by 24 publications

References 14 publications

Imaging and pathological features of gastric lesion of immunoglobulin G4-related disease: A case report and review of the recent literature

Imaging and pathological features of gastric lesion of immunoglobulin G4-related disease: A case report and review of the recent literature

Gastric IgG4-related disease presenting as a mass lesion and masquerading as a gastrointestinal stromal tumor

Immunoglobulin G4-Related Disease Manifesting as Isolated, Typical, and Nontypical Gastroesophageal Lesion: A Research of Literature Review

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