Immunoglobulin G profiles in different forms of periodontitis

Chung, Hsien-Yang; Lu, Hsi-Chi; Chen, Woan-Ling; Lu, Chun-Tai; Yang, Yoona; Tsai, Chi‐Cheng

doi:10.1034/j.1600-0765.2003.00675.x

Cited by 11 publications

(13 citation statements)

References 32 publications

(55 reference statements)

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“…A weak infl ammation response and low periodonsium resistance accompanied by ischemia will increase the invasion of periodontopathic bacteria. 6 In states of chronic stress the sIgA level declines, and in states of acute stress the level rises. This is possibly caused by the increased cortisol in saliva during stress.…”

Section: Stressmentioning

confidence: 99%

“…24 In addition, the rising cortisol will affect the immune response by reducing the chemotactic and phagocytic PMN response. 6 …”

Section: Stressmentioning

confidence: 99%

“…4 The hypersensivity reactions that are similar in periodontal diseases are Type I -anafilaxis, Type II -cytotoxic, and Type III -immune complex. 6 At the onset of periodontal diseases, adhesion and aggregation of bacteria is impeded by antibodies and complements in the fluids of the gaps in the gums at the same time dissolve it so that a reduction in the amount of bacteria occurs. When the host immune response is insufficient, the products of the following bacterial invasion will continue.…”

Section: Immune Response Of Periodontal Diseasesmentioning

confidence: 99%

“…8 Control of malignancy with chemotherapeutic substances has direct effects at the cellular level and not indirectly through myelo-immunosuppression of hematopoietic and lymphoid tissue. 6 Secondary immunodefi ciency can also occur in the use of various types of medicine, such as phenacetin, chloramphenicol, or anti-thyroid and anti-convulsion medicines. 8 Acute periodontal infection in users of these medicines occurs because of exacerbation of chronic conditions due to the increased periodontopathic bacteria during episodes of granulocytopenia.…”

Section: Use Of Medicationmentioning

confidence: 99%

“…6 Phenacetin, which is used in the control of epilepsy, suppresses serum IgA. 8 Control of malignancy with chemotherapeutic substances has direct effects at the cellular level and not indirectly through myelo-immunosuppression of hematopoietic and lymphoid tissue.…”

Section: Use Of Medicationmentioning

confidence: 99%

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The relation of periodontal diseases to systemic diseases

Djamil

Roeslan

2008

Dent. J. (Majalah Kedokteran Gigi)

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Section: Stressmentioning

confidence: 99%

“…24 In addition, the rising cortisol will affect the immune response by reducing the chemotactic and phagocytic PMN response. 6 …”

Section: Stressmentioning

confidence: 99%

Section: Immune Response Of Periodontal Diseasesmentioning

confidence: 99%

Section: Use Of Medicationmentioning

confidence: 99%

Section: Use Of Medicationmentioning

confidence: 99%

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The relation of periodontal diseases to systemic diseases

Djamil

Roeslan

2008

Dent. J. (Majalah Kedokteran Gigi)

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Circulating antibodies against leukotoxin A as marker of periodontitis Grades B and C and oral infection with Aggregatibacter actinomycetemcomitans

Damgaard

Danielsen

Enevold

et al. 2021

Journal of Periodontology

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Background:The facultative bacterium Aggregatibacter actinomycetemcomitans (Aa) is strongly associated with periodontitis and is occasionally found in periodontally healthy subjects. We aimed to determine the prevalence of salivary Aa among patients with either periodontitis Grade B (periodontitis-B) or Grade C (periodontitis-C), periodontally healthy controls (HCs), and to determine if systemic antibodies against Aa or its virulence factor leukotoxin A (LtxA) may serve as biomarkers that reveal the oral presence of the bacterium and discriminate subjects with periodontitis-C, periodontitis-B, or no periodontitis from each other.Methods: Serum and unstimulated saliva samples were collected from patients with periodontitis-C (n = 27), patients with periodontitis-B (n = 34), and HCs (n = 28). Serum level of immunoglobulin G antibodies to fragmented whole Aa and to LtxA were quantified using a bead-based assay. Aa was identified in saliva using quantitative polymerase chain reaction (qPCR). All analyses were adjusted for age, sex, and current smoking status.Results: Aa was present in saliva from 11% of HCs, in 32% of patients with periodontitis-B (P = 0.04 versus HCs), and in 37% of patients with periodontitis-C (P = 0.02 versus HCs). Serum antibodies to fragments of Aa associated significantly with periodontitis-C (P = 0.03), while serum anti-LtxA antibodies associated with both periodontitis-B and periodontitis-C (P = 0.002 and P = 9×10 −4 , respectively). Moreover, a significant association between serum anti-LtxA antibodies and Aa count in saliva was observed (P = 0.001). On the basis of serum anti-LtxA antibody levels, patients with periodontitis could be discriminated from HCs (AUC = 0.74 in ROC curve-analysis, P = 0.0003), and carriers of Aa could be discriminated from non-carriers (AUC = 0.78, P <0.0001). Conclusions: Aa is highly prevalent in saliva of patients with periodontitis-B or periodontitis-C. Systemic immunoglobulin G antibodies against LtxA distinguish patients with periodontitis, regardless of grade, from HCs, while their quantity reflects the concurrent bacterial burden in the oral cavity.

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Immunoglobulin G antibodies againstPorphyromonas gingivalisorAggregatibacter actinomycetemcomitansin cardiovascular disease and periodontitis

Damgaard

Reinholdt

Enevold

et al. 2017

Journal of Oral Microbiology

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Objectives: The aim was to elucidate whether levels of circulating antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis correlate to loss of attachment, as a marker for periodontitis and cardiovascular disease (CVD). Design: Sera were collected from 576 participants of the Danish Health Examination Survey (DANHES). Immunoglobulin G antibodies against lipopolysaccharide (LPS) and protein antigens from the a, b and c serotypes of A. actinomycetemcomitans and P. gingivalis were quantified by titration in ELISA plates coated with a mixture of antigens prepared by disintegration of bacteria. Results: Levels of antibodies against P. gingivalis (OR = 1.48) and A. actinomycetemcomitans (1.31) associated with periodontitis, as determined by univariable logistic regression analysis. These antibody levels also associated with CVD (1.17 and 1.37), respectively, However, after adjusting for other risk factors, including age, smoking, gender, alcohol consumption, overweight, and level of education using multivariable logistic regression analysis, only increasing body mass index (BMI; 1.09), previous smoking (1.99), and increasing age (decades) (2.27) remained associated with CVD. Increased levels of antibodies against P. gingivalis (1.34) remained associated with periodontitis after adjusting for other risk factors. Conclusions: CVD and periodontitis were associated with levels of IgG antibodies to P. gingivalis or A. actinomycetemcomitans in univariable analyses, but only the association of P. gingivalis antibody levels with periodontitis reached statistical significance after adjustment for common confounders. Age, in particular, influenced this relationship.

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Immunoglobulin G profiles in different forms of periodontitis

Cited by 11 publications

References 32 publications

The relation of periodontal diseases to systemic diseases

The relation of periodontal diseases to systemic diseases

Circulating antibodies against leukotoxin A as marker of periodontitis Grades B and C and oral infection with Aggregatibacter actinomycetemcomitans

Immunoglobulin G antibodies againstPorphyromonas gingivalisorAggregatibacter actinomycetemcomitansin cardiovascular disease and periodontitis

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