Immunoglobulin G antibodies against indoor dampness-related microbes and adult-onset asthma: a population-based incident case–control study

Jaakkola, Maritta S.; Laitinen, Sirpa; Piipari, Ritva; Uitti, Jukka; Nordman, Henrik; Haapala, Anna‐Maija; Jaakkola, Jouni J. K.

doi:10.1046/j.1365-2249.2002.01884.x

Cited by 32 publications

(26 citation statements)

References 16 publications

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“…Indoor dampness-related microbes are associated with asthma-related symptoms in adults [22] and might favor the existence of dust mites and molds. On the other hand, dehumidifier use is negatively associated with airborne endotoxin [23], which has been associated with severity of nonatopic asthma and adult asthma [24].…”

Section: Discussionmentioning

confidence: 99%

Different Severity and Severity Predictors in Early-Onset and Late-Onset Asthma: A Taiwanese Population-Based Study

Chen

Lee

et al. 2015

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Background: Late-onset asthma has been shown to be more severe than early-onset asthma in clinic-based studies. However, population-based studies are scarce, and the predictors of severity have been less studied. Objectives: To determine asthma severity and severity predictors regarding age at onset. Methods: A cross-sectional questionnaire survey was conducted among parents of children from 94 schools in Taiwan in 2004. Asthma severity was defined as short-acting β₂-agonist (SABA), inhaled corticosteroid (ICS) and health care use in the last year. Information on age at onset, demographics, heredity and home exposure was collected. Ordered logistic or logistic regression was used for determining the associations between risk factors and severity. Results: Participants aged 26-50 years were included, resulting in 21,057 (67.8%) participants. Among them, 449 reported ever having had physician-diagnosed asthma, and 381 of those subjects answered the question on age at asthma onset. The risks of rescue SABA, ICS and health care use were generally higher among late-onset (13-50 years) than early-onset (0-12 years) asthmatics. Use of SABA and health care increased from childhood-onset, adolescent- or young adult-onset to adult-onset asthma. Allergic rhinitis was positively associated with SABA use (OR, 9.08; 95% CI, 1.06-77.99) and ICS use (OR, 5.08; 95% CI, 1.47-17.52) in early-onset asthma. Dehumidifier use was negatively associated with SABA use (OR, 0.50; 95% CI, 0.29-0.87) and ICS use (OR, 0.38; 95% CI, 0.19-0.78) in late-onset asthma. Conclusions: In adults, late-onset asthma was more severe than early-onset asthma. Severity, as indicated by SABA and ICS use, was positively associated with allergic rhinitis in early-onset asthma and negatively associated with dehumidifier use in late-onset asthma.

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Section: Discussionmentioning

confidence: 99%

Different Severity and Severity Predictors in Early-Onset and Late-Onset Asthma: A Taiwanese Population-Based Study

Chen

Lee

et al. 2015

Respiration

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“…The genus includes species reported to cause mycoses and allergy in humans (12,31,36,59). Toxin production has also been reported, and some species can be preservative resistant in food products (45,56).…”

Section: Discussionmentioning

confidence: 99%

Diversity and Significance of Mold Species in Norwegian Drinking Water

Hageskal

Knutsen

Gaustad

et al. 2006

Appl Environ Microbiol

155

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In order to determine the occurrence, distribution, and significance of mold species in groundwater-and surface water-derived drinking water in Norway, molds isolated from 273 water samples were identified. Samples of raw water, treated water, and water from private homes and hospital installations were analyzed by incubation of 100-ml membrane-filtered samples on dichloran-18% glycerol agar. The total count (number of CFU per 100 ml) of fungal species and the species diversity within each sample were determined. The identification of mold species was based on morphological and molecular methods. In total, 94 mold species belonging to 30 genera were identified. The mycobiota was dominated by species of Penicillium, Trichoderma, and Aspergillus, with some of them occurring throughout the drinking water system. Several of the same species as isolated from water may have the potential to cause allergic reactions or disease in humans. Other species are common contaminants of food and beverages, and some may cause unwanted changes in the taste or smell of water. The present results indicate that the mycobiota of water should be considered when the microbiological safety and quality of drinking water are assessed. In fact, molds in drinking water should possibly be included in the Norwegian water supply and drinking water regulations.

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“…Although exposure to T. citrinoviride in damp buildings has been associated with an increased risk of developing adult asthma, as determined by increased concentrations of IgG antibody levels, the findings do not correlate with a causal relationship (11). T. viride has been shown to produce volatile trichothecene compounds which can induce histamine release from human mast …”

mentioning

confidence: 97%

Allergic Fungal Sinusitis Associated with Trichoderma longibrachiatum

et al. 2003

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We describe allergic fungal sinusitis caused by Trichoderma longibrachiatum in a patient with a history of atopy and asthma. A Gram stain of a sinus biopsy specimen was initially thought to contain yeast cells, but when Trichoderma was recovered in culture, these cells were subsequently recognized as chlamydospores. The patient was successfully managed with a combination of sinus lavage, oral corticosteroids, itraconazole, and allergen immunotherapy. This case also points out that careful scrutiny of direct smears is required to ensure that fungal structures are not misinterpreted.

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Immunoglobulin G antibodies against indoor dampness-related microbes and adult-onset asthma: a population-based incident case–control study

Cited by 32 publications

References 16 publications

Different Severity and Severity Predictors in Early-Onset and Late-Onset Asthma: A Taiwanese Population-Based Study

Different Severity and Severity Predictors in Early-Onset and Late-Onset Asthma: A Taiwanese Population-Based Study

Diversity and Significance of Mold Species in Norwegian Drinking Water

Allergic Fungal Sinusitis Associated with Trichoderma longibrachiatum

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