Immunoglobulin A (IgA) content of human breast milk over time

Rechtman, David J.; Ferry, B; Lee, M.L.; Chapel, H

doi:10.1016/s1201-9712(02)90302-4

Cited by 10 publications

(9 citation statements)

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“…We only had a 1‐point measurement of the two breast milk components measured at month 2. However, it has been shown that after a drop in sIgA concentrations in breast milk 10 days post‐partum, the levels did not change significantly during the first year of life , and TGF‐β levels have been shown to be relatively constant at least throughout the first 3 months after birth . It thus can be assumed that the 2‐month measurements are representative of the levels the infants consumed during lactation.…”

Section: Discussionmentioning

confidence: 99%

Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: the PASTURE cohort study

Orivuori

Loss

Roduit

et al. 2013

Clin Experimental Allergy

112

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Section: Discussionmentioning

confidence: 99%

Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: the PASTURE cohort study

Orivuori

Loss

Roduit

et al. 2013

Clin Experimental Allergy

112

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“…Therapeutic perspectives have been proposed by the use of specific antibodies from BM, since specific IgA and other classes of antibodies seems to persist during lactation in affected/immunized mothers for at least seven months [ 109 ]. In fact, antibodies could be potentially collected, purified and used to prevent SARS-CoV-2 infection or to reduce symptoms in infected subjects [ 24 ], although specific data on anti-SARS-CoV-2 titers duration are not available.…”

Section: Discussionmentioning

confidence: 99%

Breast Milk and COVID-19: From Conventional Data to “Omics” Technologies to Investigate Changes Occurring in SARS-CoV-2 Positive Mothers

Bardanzellu

Puddu

Fanos

2021

IJERPH

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In this context of COVID-19 pandemic, great interest has been aroused by the potential maternal transmission of SARS-CoV-2 by transplacental route, during delivery, and, subsequently, through breastfeeding. Some open questions still remain, especially regarding the possibility of finding viable SARS-CoV-2 in breast milk (BM), although this is not considered a worrying route of transmission. However, in BM, it was pointed out the presence of antibodies against SARS-CoV-2 and other bioactive components that could protect the infant from infection. The aim of our narrative review is to report and discuss the available literature on the detection of anti-SARS-CoV-2 antibodies in BM of COVID-19 positive mothers, and we discussed the unique existing study investigating BM of SARS-CoV-2 positive mothers through metabolomics, and the evidence regarding microbiomics BM variation in COVID-19. Moreover, we tried to correlate metabolomics and microbiomics findings in BM of positive mothers with potential effects on breastfed infants metabolism and health. To our knowledge, this is the first review summarizing the current knowledge on SARS-CoV-2 effects on BM, resuming both “conventional data” (antibodies) and “omics technologies” (metabolomics and microbiomics).

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“…Additionally, the same study demonstrated the presence of IgG and/or IgM in eight of 12 patients postinfection, but IgA and IgG were found at highest levels. Other study also detected IgA reactivity to SARS‐CoV‐2 in 97% (39 women) of breast milk samples (Demers‐Mathieu et al, 2020) As these antibodies persist in breastmilk in high levels for at least 7 months postpartum (Rechtman et al, 2002), they may be used as a therapy to prevent SARS‐CoV‐2 infection or COVID‐19 symptoms in the first year of life. Moreover, the large‐scale production of these antibodies may help the recovery in severe cases.…”

Section: Breastmilk Composition and Its Antimicrobial Rolementioning

confidence: 94%

Breastfeeding importance and its therapeutic potential against SARS‐CoV‐2

2021

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During postnatal development, colostrum and breastmilk are sequentially the first sources of nutrition with protein components and bioactive molecules that confer protection and immunostimulatory function to the gut. Caseins, whey proteins, secretory immunoglobulin A (sIgA), mucins, tryptophan, and growth factors are among milk‐borne elements that are directly important in the control of mucosa development and protection. Consequently, breastfeeding is associated with the low incidence of gastrointestinal inflammation and with the decrease in respiratory diseases during postnatal period. The novel coronavirus (SARS‐CoV‐2) binds to angiotensin II‐converting enzyme (ACE2) on the cell membrane, allowing virus entrance, replication, and host commitment. ACE2 is expressed by different cell types, which include ciliated cells in the lungs and enterocytes in the intestine. Such cells are highly active in metabolism, as they internalize molecules to be processed and used by the organism. The disruption of ACE2 impairs leads to intestinal inflammation and decreased synthesis of serotonin, affecting motility. By reviewing the effects of SARS‐CoV‐2 in the gastrointestinal and respiratory tracts in infants, and gut responses to breastfeeding interruption, we suggest that it is important to maintain breastfeeding during SARS‐CoV‐2 infection, as it might be essential to protect newborns from gastrointestinal‐associated disorders and relieve disease symptoms.

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Immunoglobulin A (IgA) content of human breast milk over time

Cited by 10 publications

References 0 publications

Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: the PASTURE cohort study

Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: the PASTURE cohort study

Breast Milk and COVID-19: From Conventional Data to “Omics” Technologies to Investigate Changes Occurring in SARS-CoV-2 Positive Mothers

Breastfeeding importance and its therapeutic potential against SARS‐CoV‐2

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