Immunogenicity of second dose measles–mumps–rubella (MMR) vaccine and implications for serosurveillance

Pebody, Richard; GAY, N. J.; Hesketh, Louise; Vyse, Andrew; Morgan‐Capner, P.; Brown, David; Litton, P. A.; Miller, Elizbeth

doi:10.1016/s0264-410x(01)00435-2

Cited by 75 publications

(57 citation statements)

References 41 publications

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“…These data are consistent with previous experience with the component vaccines, M-M-R ® II and VARI-VAX ® . 42,48,49 A second dose of the vaccine in the studies was well tolerated; the frequencies of adverse experiences after a second dose of the vaccine were generally equal to or lower than the frequencies following the first dose. The data also support the use of ProQuad ® in 4-to 6-year-old children who previously received primary doses of M-M-R ® II and VARIVAX ® .…”

Section: Discussionmentioning

confidence: 96%

Safety and Immunogenicity of a Combination: Measles, Mumps, Rubella and Varicella Vaccine (ProQuad®)

Kuter

Brown²,

Hartzel³

et al. 2006

Human Vaccines

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Section: Discussionmentioning

confidence: 96%

Safety and Immunogenicity of a Combination: Measles, Mumps, Rubella and Varicella Vaccine (ProQuad®)

Kuter

Brown²,

Hartzel³

et al. 2006

Human Vaccines

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“…Higher susceptibility may also reflect a decline in the antibody levels from childhood vaccinations, as this cohort would have been eligible for two doses of rubella-containing vaccine, although data from surveillance of rubella and CRS suggest that waning immunity with increased susceptibility to rubella does not occur [10,25,32,33]. In 2012, Spanish national coverage of the first dose of MMR vaccine in infants was > 95%, but only 90% for the second dose [34].…”

Section: Discussionmentioning

confidence: 99%

Rubella susceptibility in pregnant women and results of a postpartum immunization strategy in Catalonia, Spain

Vilajeliu

García‐Basteiro

Valencia

et al. 2015

Vaccine

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.4-1.8) were more likely to be susceptible. The second dose of MMR vaccine was received by 57.2% (718/1256) of rubella-susceptible women, with the highest proportion being immigrant women compared with women born in Spain. After vaccination, all women showed rubella immunity. Conclusions:The higher rubella susceptibility found in the three youngest age groups and in immigrant women highlights the relevance of antenatal screening, in order to ensure identification and postpartum immunization. The postpartum immunization strategy is an opportunity to protect women of childbearing age and consequently prevent occurrence of CRS, and to increase vaccination coverage against rubella and other vaccine-preventable diseases.

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“…The administration of a second MMR dose has been shown to boost serum IgG antibody levels [27,28], although it remains unclear whether waning antibody levels represents secondary vaccine failure or if other mechanisms of immunity exist [24,28]. In Denmark and in the Netherlands, an increase in mumps virus antibody positivity was observed in those birth cohorts in whom a second MMR dose had been administered.…”

Section: Discussionmentioning

confidence: 99%

Sero-epidemiology of mumps in western Europe

Nardone¹,

Pebody²,

Hof

et al. 2003

Epidemiol. Infect.

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SUMMARYSix countries (Denmark, England and Wales, France, Germany, Italy and the Netherlands) conducted large serological surveys for mumps, in the mid-1990s, as part of the European Sero-Epidemiology Network (ESEN). The assay results were standardized and related to the schedules and coverage of the immunization programmes and the reported incidence of mumps. Low incidence of disease and few susceptibles amongst adolescents and young adults was observed in countries with high mumps vaccine coverage (e.g. the Netherlands). High disease incidence and large proportions of mumps virus antibody negative samples in adolescent and young adult age groups was noted in countries with poor vaccine coverage (e.g. Italy). The build-up of susceptibles in older children and adolescents in England and Wales, France, the former West Germany and Italy indicate the possibility of further mumps outbreaks in secondary school environments. To control mumps in western Europe, current MMR immunization programmes will need to be strengthened in a number of countries. Sero-surveillance of mumps is an important component of disease control and its usefulness will be enhanced by the development of an international mumps standard.

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Immunogenicity of second dose measles–mumps–rubella (MMR) vaccine and implications for serosurveillance

Cited by 75 publications

References 41 publications

Safety and Immunogenicity of a Combination: Measles, Mumps, Rubella and Varicella Vaccine (ProQuad®)

Safety and Immunogenicity of a Combination: Measles, Mumps, Rubella and Varicella Vaccine (ProQuad®)

Rubella susceptibility in pregnant women and results of a postpartum immunization strategy in Catalonia, Spain

Sero-epidemiology of mumps in western Europe

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