Immunogenicity of O-Acetyl-Negative and -Positive Polysaccharide Vaccines for Infections with Neisseria meningitidis Group C in Infants

Pichichero, Michael E.; Anderson, Patrick L.; Garschlich, Emil; Kamm, June; McMullen, Ann; Nielsen, Sonja

doi:10.1093/infdis/152.4.850

Cited by 8 publications

(4 citation statements)

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“…This strain was the dominant one for the de-O-acetylated antigen during the late 1990s in the UK. However, clinical data confirmed that both O-acetylated (Menjugate, Menveo, Menitorix, Menhibrix–GSK Vaccines; Menactra–Sanofi Pasteur; Nimenrix–Pfizer) and de-O-acetylated (NeisVac–North American Vaccine Inc., later taken over by Baxter Bioscience) conjugates were very immunogenic and efficacious in large vaccination campaigns [ 18 , 19 , 20 , 21 ] independent of the used carrier protein (TT, DT, CRM 197 ). The high immunogenicity did not directly correlate to the C 7 and C 8 O-acetylation in meningococcal serogroup C. This differs from the serogroup A in which the O-acetylation seems to be determinant in the immunoresponse.…”

Section: O-acetylation In Conjugate Vaccinesmentioning

confidence: 99%

Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines

Berti

Ricco²,

Rappuoli

2018

Molecules

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The incidence of infectious diseases caused by several bacterial pathogens such as Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis, has been dramatically reduced over the last 25 years through the use of glycoconjugate vaccines. The structures of the bacterial capsular polysaccharide (CPS) antigens, extracted and purified from microbial cultures and obtained with very high purity, show that many of them are decorated by O-acetyl groups. While these groups are often considered important for the structural identity of the polysaccharides, they play a major role in the functional immune response to some vaccines such as meningococcal serogroup A and Salmonella typhi Vi, but do not seem to be important for many others, such as meningococcal serogroups C, W, Y, and type III Group B Streptococcus. This review discusses the O-acetylation status of CPSs and its role in the immunological responses of these antigens.

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Section: O-acetylation In Conjugate Vaccinesmentioning

confidence: 99%

Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines

Berti

Ricco²,

Rappuoli

2018

Molecules

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“…Meningococcal polysaccharide vaccines containing either Oac + or Oac − serogroup C polysaccharide have been evaluated and the Oac − polysaccharide found to be more immunogenic [11–13]. Oac − and Oac + MCC vaccines have now been trialled in head to head comparisons with the result that the Oac − MCC vaccine demonstrated significantly higher serum bactericidal titres than either of the two Oac + MCC vaccines [5].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of de-O-acetylated serogroup C meningococci before the introduction of meningococcal serogroup C conjugate vaccines in the United Kingdom

Borrow

Longworth

Gray

et al. 2000

FEMS Immunology &Amp; Medical Microbiology

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Meningococcal serogroup C conjugate (MCC) vaccines have been introduced in the UK to combat the rise in serogroup C meningococcal disease. Serogroup C meningococci may occur naturally expressing either O-acetylated (Oac(+)) or de-O-acetylated (Oac(-)) polysaccharide capsules. In a small study in the USA in the 1970s 15% of serogroup C meningococcal case isolates were reported to be Oac(-) though the prevalence of these Oac(-) isolates has not been recorded in the UK. This is of interest as the first MCC vaccines to be introduced are Oac(+) and the potential impact of this on Oac(-) serogroup C isolates is unclear. Serogroup C isolates submitted to the Public Health Laboratory Service Meningococcal Reference Unit in January 1998 (n=113) and January 1999 (n=162) were investigated by dot blotting using monoclonals specific for Oac(+) and Oac(-) serogroup C polysaccharides. This revealed 12% Oac(-) isolates for both January 1998 and January 1999. The proportion of fatal cases was found to similar for both Oac(-) and Oac(+), 14 and 9% for 1998 and 5 and 3% for 1999, indicating that the pathogenic potential of these Oac(-) isolates is similar to Oac(+). The acetylation status of serogroup C isolates needs to be monitored throughout and after the introduction of MCC vaccines.

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“…Early studies found OAcϪ MCPS to be more immunogenic than OAcϩ MCPS in adults and children (14,31) but not in infants (24). North American Vaccine Inc. (Columbia, Md.)…”

mentioning

confidence: 99%

Evaluation of De-O-Acetylated Meningococcal C Polysaccharide-Tetanus Toxoid Conjugate Vaccine in Infancy: Reactogenicity, Immunogenicity, Immunologic Priming, and Bactericidal Activity against O-Acetylated and De-O-Acetylated Serogroup C Strains

et al. 2001

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Immunogenicity of O-Acetyl-Negative and -Positive Polysaccharide Vaccines for Infections with Neisseria meningitidis Group C in Infants

Cited by 8 publications

References 0 publications

Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines

Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines

Prevalence of de-O-acetylated serogroup C meningococci before the introduction of meningococcal serogroup C conjugate vaccines in the United Kingdom

Evaluation of De-O-Acetylated Meningococcal C Polysaccharide-Tetanus Toxoid Conjugate Vaccine in Infancy: Reactogenicity, Immunogenicity, Immunologic Priming, and Bactericidal Activity against O-Acetylated and De-O-Acetylated Serogroup C Strains

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