Immunogenicity and cytotoxicity of a platinum(iv) complex derived from capsaicin

Abstract

A platinum(iv) complex DCP acts as a chemoimmunotherapeutic agent and induces cancer cell death by damaging DNA, stimulating immunogenic response, and enhancing phagocytosis.

A novel star-shaped trinuclear platinum(ii) complex based on a 1,3,5-triazine core displaying potent antiproliferative activity against TNBC by the mitochondrial injury and DNA damage mechanism

“…55 Mitochondrial membrane potential (MMP, Δ Ψ m ) has been recognized as a key indicator of mitochondrial function. 56 To establish whether apoptosis induced by complex 1 is related to mitochondrial dysfunction, MDA-MB-231 cells were treated with 1 at the indicated concentrations for 24 h and Δ Ψ m was evaluated by flow cytometry using a 5,5′,6,6′-tetrachloro-1,1′3,3′-tetraethylbenzimidazolycarbocyanine iodide (JC-1) kit. Cisplatin was used as a reference drug.…”

Rising Interest in the Development of Metal Complexes in Cancer Immunotherapy

“…[62] In addition, capsaicin also has the effect of activating the immune system and reducing cancer immunosuppression. [63] According to the above studies, Sun et al [64] designed a Pt(IV) complex (Pt11; Figure 2) containing a capsaicin derivative as the axial ligand. Pt11 not only induces ICD in tumor cells, but also triggers an immune response by releasing the proinflammatory cytokines IFN-γ and TNF-α.…”

“…In addition, capsaicin also has the effect of activating the immune system and reducing cancer immunosuppression [63] . According to the above studies, Sun et al [64] . designed a Pt(IV) complex ( Pt11 ; Figure 2) containing a capsaicin derivative as the axial ligand.…”

Immunogenic ferroptosis and where to find it?

“…Apoptosis was previously thought to be tolerogenic, 34 but in certain cases, and more specifically in apoptotic cancer cells, it could activate the immune system. [35][36][37][38] This immunogenic apoptosis was associated with the release of HMGB1 and exposure of CRT, thus causing immune cell activation. [39][40][41] HMGB1 and ATP release have also been observed in necroptosis.…”