Immunogenetic study on the polymorphism of serum ?2-lipoprotein in mink. III. Ld1 allotype of low-density lipoprotein

Baranov, O. K.; Savina, M. A.

doi:10.1007/bf00498974

Cited by 4 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…. .16mink sera tested for lipids; (3) LdI and Ld2 have a hydrate density ranging from 1.006-1 .I00 glml which is characteristic of LDL; (4) allotypes Ldl and Ld2 present in the purified LDL fraction, and isotypically identical to it (BARANOV, SAVINA 1979;1981).…”

Section: The Ld-system Identificationmentioning

confidence: 99%

The organization and evolution of the immunogenetic systems in the American mink

Baranov

1988

J Animal Breeding Genetics

Self Cite

View full text Add to dashboard Cite

Section: The Ld-system Identificationmentioning

confidence: 99%

The organization and evolution of the immunogenetic systems in the American mink

Baranov

1988

J Animal Breeding Genetics

Self Cite

View full text Add to dashboard Cite

Immunogenetic study on the polymorphism of serum ?2-lipoproteins in mink. IV. Diallelism at the Ld locus of low-density lipoprotein

Baranov

Savina

1981

Biochem Genet

View full text Add to dashboard Cite

Antibodies against a new allotype, Ld2, of mink low-density lipoprotein (LDL) were obtained by alloimmunization with a preparation of this lipoprotein. The two known allotypes of LDL, designated Ld1 and Ld2, are coded for by codominant alleles of the autosomal Ld locus. This locus is probably involved in the genetic control of the whole serum pool of LDL molecules. In Ld1/Ld2 heterozygotes, LDL is represented by two homozygous types of molecules, Ld1 and Ld2; it has no hybrid molecules bearing both allotypic specificities together. The results suggest that the Ld locus has, presumably, only two alleles in the mink populations studies. Mink LDL having allotypes Ld1 and Ld2 was found to be homologous to human and pig LDLs. Antigenic specificity of Ld1 allotype was established in the sera of a wide phylogenetic range of mammals and in the human LDL. The parallelism between the phylogenetic antiquity of the Ld1 gene and its high frequency in mink and other species may be attributed to the selective value of this gene, which has been retained unaltered during macroevolution.

show abstract

INTERSPECIFIC DISTRIBUTION OF ALLOTYPIC MINK (MUSTELA VISION) IgG ANTIGENS

Baranov

Fomicheva

Ternovsky

et al. 1981

Int J Immunogenetics

Self Cite

View full text Add to dashboard Cite

Summary The antigenic specificities of six (1‐6) IgG allotypes of the domestic mink were tested in the sera of closely related species of Mustelidae family and distant mammalian species. It was found that allotypes 1 and 5 are ancient. Their antigenic specificities were established not only in Mustelidae, but also in other taxonomic orders of mammals. Allotypes 3 and 2 are phylogenetically younger; they were detected only in Mustelidae. Allotypes 4 and 6 appear to be unique to the domestic mink. The instantaneous evolutionary emergence of complex allotypes 4 and 6 is difficult to explain by a rapid accumulation of gene point mutations during phylogenesis. Activation in the domestic mink of those immunoglobulin genes, which are silent or poorly expressed in closely related Mustelidae, is suggested as a more plausible explanation.

show abstract

Immunogenetic study on the polymorphism of serum ?2-lipoprotein in mink. III. Ld1 allotype of low-density lipoprotein

Cited by 4 publications

References 15 publications

The organization and evolution of the immunogenetic systems in the American mink

The organization and evolution of the immunogenetic systems in the American mink

Immunogenetic study on the polymorphism of serum ?2-lipoproteins in mink. IV. Diallelism at the Ld locus of low-density lipoprotein

INTERSPECIFIC DISTRIBUTION OF ALLOTYPIC MINK (MUSTELA VISION) IgG ANTIGENS

Contact Info

Product

Resources

About