Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis

Abstract

The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction- sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.

Estimation of hearing impairment occurrence in patients with Lyme borreliosis – preliminary study

“…They include complex inflammatory and autoimmune processes affecting the target cells and organs [29,30,31,32,33]. The course of the disease may be associated with HLA-DR molecules and depend on HLA-DRB1 alleles [34,35]. The pathomechanism of articular changes comprises adhesion mechanisms and interactions between bacteria, neutrophils and the epithelial cells [36], binding of borrelial lipoproteins to TLR-2 and to integrin α 3 β 1 , with activation of metalloproteinases and elevated activity of lysosomal exoglycosidases, resulting in oxidative process balance disorders, oxygen stress and the release of proinflammatory cytokines and chemokines [37,38,39,40,41,42].…”

A Pilot Study on Markers of Genetic Predisposition in Tuberculous Pneumonia Patients In Latgale

“…HLA-DRB1*07 was identified as a risk allele in a study on Iranian TB patients (Amirzargar et al, 2004). The HLA-DRB1*07 allele was also among the risk alleles for Latvian Lyme disease patients and was strongly associated with the development of severe forms of neuroborreliosis (Kovalchuka et al, 2016). Therefore, this allele is not specific for TB.…”