1990
DOI: 10.1002/ajh.2830330303
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Immunogenetic analysis of bone marrow aspirates in patients with non‐hodgkin lymphomas

Abstract: The immunogenetic analysis (IGA) on the staging bone marrow aspirates in 15 patients with non-Hodgkin lymphoma (NHL) is reported. We found the sensitivity of IGA and morphologic examination in detecting bone marrow involvement by malignant lymphoma to be 91% and 82%, respectively. In 11 cases there was agreement between the morphologic findings and IGA. In 8 of these 11 cases, IGA confirmed the morphologic involvement of the bone marrow by demonstrating clonal rearrangement of either the immunoglobulin heavy- … Show more

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Cited by 4 publications
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“…Molecular testing initially employed Southern blot (SB) analysis to detect these rearrangements 15. Such analysis of BM aspiration cells showed good concordance with the morphology as well as increased sensitivity and specificity 16, 17. Patients with evidence of BM involvement by SB without morphologic evidence showed significantly shorter disease free survival 17.…”
mentioning
confidence: 99%
“…Molecular testing initially employed Southern blot (SB) analysis to detect these rearrangements 15. Such analysis of BM aspiration cells showed good concordance with the morphology as well as increased sensitivity and specificity 16, 17. Patients with evidence of BM involvement by SB without morphologic evidence showed significantly shorter disease free survival 17.…”
mentioning
confidence: 99%