Immunogenesis in White Mice Infected with Yersinia pestis with Different Plasmid Composition

Балахонов, С. В.; Vityazeva, S. A.; Дубровина, В. И.; Старовойтова, Т. П.; Мухтургин, Г. Б.; Иванова, Т. А.; Korytov, K. M.; Kolesnikov, S. I.

doi:10.1007/s10517-017-3642-0

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…Several other seemingly useful live-attenuated vaccine candidates with varying plasmid compositions have also emerged. Y. pestis subspecies altaica 1-2948/3, 1-3749, and 1/3480 were able to elicit strong cell-mediated responses in a mouse model of infection (Balakhonov et al 2017 ). In that same vein, a direct comparison of the virulence of the Y. pestis EV vaccine strain to the microtus 201 (avirulent in humans) strain in an intravenous (i.v.)…”

Section: Introductionmentioning

confidence: 99%

Plague vaccines: new developments in an ongoing search

Rosenzweig

Hendrix

Chopra

2021

Appl Microbiol Biotechnol

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As the reality of pandemic threats challenges humanity, exemplified during the ongoing SARS-CoV-2 infections, the development of vaccines targeting these etiological agents of disease has become increasingly critical. Of paramount concern are novel and reemerging pathogens that could trigger such events, including the plague bacterium Yersinia pestis . Y. pestis is responsible for more human deaths than any other known pathogen and exists globally in endemic regions of the world, including the four corners region and Northern California in the USA. Recent cases have been scattered throughout the world, including China and the USA, with serious outbreaks in Madagascar during 2008, 2013–2014, and, most recently, 2017–2018. This review will focus on recent advances in plague vaccine development, a seemingly necessary endeavor, as there is no Food and Drug Administration–licensed vaccine available for human distribution in western nations, and that antibiotic-resistant strains are recovered clinically or intentionally developed. Progress and recent development involving subunit, live-attenuated, and nucleic acid–based plague vaccine candidates will be discussed in this review. Key points • Plague vaccine development remains elusive yet critical. • DNA, animal, and live-attenuated vaccine candidates gain traction.

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Section: Introductionmentioning

confidence: 99%

Plague vaccines: new developments in an ongoing search

Rosenzweig

Hendrix

Chopra

2021

Appl Microbiol Biotechnol

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“…On the other hand, female hamsters often cannibalize their offspring and hibernate (especially in the period from October to February) [7][8][9]. Animals suffering from cannibalism lack macromicroelements in the body that leads to the development of suppressive reactions of the immune system [10].…”

Section: Introductionmentioning

confidence: 99%

Morphofunctional changes of the spleen when correcting hamsters' body with bee-keeping products in ontogenesis

et al. 2019

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T HE aim of our research is to study the indicators of growth, development, immunomorphological alteration in the structural components of the spleen during correction of the body of hamsters under experimental loading with biologically active bee-keeping products (BABP), "Microvitum" preparation and their composite forms and without it. There was conducted comprehensive research to identify experience of growth, development, proliferation processes, differentiation, alteration of structural and functional components of the spleen in postnatal ontogenesis of hamsters and under experimental loading on the body with BABP, "Microvitum" preparation and their composite forms. The study found: the dynamics of change in the spleen weight, the absolute values of the average daily liveweight gain of hamsters in postnatal ontogenesis and on the background of introduced BABP (pollen, royal jelly), amino acid-mineral-vitamin preparation "Microvitum" and their composite forms to the diet; macro-and microstructure as well as immunomorphological alteration in the spleen of hamsters in postnatal ontogenesis and under the effect of BABP, "Microvitum" preparation and their composite forms; the relationship of the structural components of the spleen, T-and B-lymphocytes and their populations in the blood that condition immunobiological response of the harmster body in postnatal ontogenesis and ways to correct it with BABP, "Microvitum" preparation and their composite forms; the effect of the experimental loading on immunomorphological response of the spleen, the cellular and humoral component of the immune system and against the background of BABP, "Microvitum" and their composite forms introduced into the diet; ways to correct performance efficiency of hamsters, prevention of cannibalism and female hibernation with BABP, "Microvitum" and their composite forms.

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Morphofunctional changes in the kidneys of mice with the use of adaptogens against the background of physical exertion

Khabibullin

Mironova

Дерхо

et al. 2020

IOP Conf. Ser.: Earth Environ. Sci.

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When performing maximum physical activity, the main role for maintaining motor activity and homeostasis of the animal body is given to the kidneys. In this regard, the purpose of our research is to study morphological changes in the body of laboratory animals during physical exertion and the use of biologically active substances. One of the first to carry out a comprehensive assessment of the histological changes in experimental animals when given adaptogens (tincture of moral root, pantocrine and a combination of the same drugs with oats) against the background of maximum loads. The dosage of adaptogens was calculated according to the method proposed by Clark, based on the live weight of the animals. Which was 2 μl at the beginning of the experiment, subsequently the dosage was increased to 6 μl for all experimental groups. The first group was given distilled water, and the experimental group received leuzea tincture and oatsol. Ovesol was poured in a dose of 4 μl from 22 to 26 days. The total duration of the experiment was 28 days. It was also found that the use of tincture of moral root (safflower leuzea) and pantocrine prior to physical exertion makes it possible to correct histological changes.

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Immunogenesis in White Mice Infected with Yersinia pestis with Different Plasmid Composition

Cited by 6 publications

References 3 publications

Plague vaccines: new developments in an ongoing search

Plague vaccines: new developments in an ongoing search

Morphofunctional changes of the spleen when correcting hamsters' body with bee-keeping products in ontogenesis

Morphofunctional changes in the kidneys of mice with the use of adaptogens against the background of physical exertion

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