Immunofluorescent localization of angiotensin converting enzyme in epithelioid and giant cells of sarcoidosis granulomas.

Silverstein, Emanuel; Pertschuk, Louis P.; Friedland, Joan

doi:10.1073/pnas.76.12.6646

Cited by 136 publications

(65 citation statements)

References 21 publications

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“…Since the evidence has been brought that ACE is produced by epitheloid cells of sarcoid granulomas, and after the elevated serum ACE levels (sACE) were found in patients with sarcoidosis, sACE has been proposed to be the marker of sarcoidosis activity, susceptibility and prognosis (Pertschuk et al 1981;Lieberman 1975;Meeting Report 1994). It has also been demonstrated that ACE synthesis in a monocyte cell culture can be modulate by T lymphocytes obtained from sarcoid patients (Silverstein et al 1979). It is now believed that sACE reflects the whole body granuloma mass (Ainslie et Benatar 1985).…”

Section: Discussionmentioning

confidence: 99%

Role of genetic polymorphisms in ACE and TNF-α gene in sarcoidosis: a meta-analysis

et al. 2007

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A great number of association studies have been performed to identify the genes involved in the etiology and prognosis of sarcoidosis. We performed a systematic review of case-control studies through the PubMed database and evaluated them for a possible inclusion into a meta-analysis in order to assess whether the reported genetic polymorphisms are the risk factors of sarcoidosis. Case-control studies with clear diagnostic criteria and interventions were included. Only investigations of a single polymorphism/gene involvement in sarcoidosis reported more than five times were selected. Aggregating data from 12 studies on ID/ACE polymorphisms, the odds ratio (OR) for sarcoidosis, if the polymorphism was considered under the dominant genetic model, was not significantly increased: 1.19 (95% CI 0.98-1.43); OR under the recessive model was 1.20 (95% CI 0.98-1.46). In seven case-control studies on -308/TNF-a polymorphism, the OR for sarcoidosis if the polymorphism considered under the dominant genetic model was significantly increased at 1.47 (95% CI 1.03-2.08); the OR under the recessive model was 1.39 (95% CI 0.67-2.90). In conclusion, the results showed that the TNF-a genotype could be a significant risk factor for sarcoidosis, whereas the risk of sarcoidosis due to the ACE genotype was not substantially elevated.

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Section: Discussionmentioning

confidence: 99%

Role of genetic polymorphisms in ACE and TNF-α gene in sarcoidosis: a meta-analysis

et al. 2007

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“…A decreased SACE level has also been found in malignant lymphoproliferative and haematological disorders in which SACE was also associated with prognosis, though not so regularly as observed in lung cancer (R0mer & Emmertsen, 1980). With regard to other lung diseases, measurement of SACE has been mostly used in sarcoidosis (Lancet, Editorial, 1980;R0mer, 1979), where high SACE is presumably due to increased formation in the monocyte macrophage-derived noncaseating epithelioid granulomas (Silverstein et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme and its association with outcome in lung cancer

Rømer¹

1981

Br J Cancer

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Summary.-Serum angiotensin-converting enzyme (SACE) in 141 patients with newly detected primary lung cancer was 22-1 + 6-1 nmol/ml/min (mean + s.d.); lower than in healthy controls (24.4 + 6-2 nmol/ml/min, P <0.02). No correlation was found between SACE and sex, age, site of cancer, histological type, or lung function.After subdivision of the patients according to increasing SACE levels: < 16.0 (mean SACE of lung cancer -s.d.), 16-0-22-0, 22-1-28-2, and >28-2 nmol/ml/min (mean SACE of lung cancer + s.d.) there was a strong association (P <0001) between SACE level and the proportion of patients who were radically operated without relapse during 8-22 months follow-up. None of 23 patients within the lowest SACE range were cured, even though 7 were referred for operation after preoperative examination. In contrast, 10/25 patients (40%O) within the highest SACE range were cured.The results suggest that low SACE is associated with poor prognosis in lung cancer, even in patients who are judged as being operable on preoperative evaluation; and measurement of preoperative SACE in lung cancer may be a useful prognostic indicator in this disorder.

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“…The finding of a high ACE activity in sarcoid lymph nodes (Silverstein et al, 1976) and the demonstration of ACE in sarcoidosis epithelioid cells (Silverstein et al, 1979) point to the monocyte-macrophagederived epithelioid-cell granuloma as the source of high SACE in sarcoidosis.…”

mentioning

confidence: 96%

Serum angiotensin-converting enzyme in malignant lymphomas, leukaemia and multiple myeloma

Rømer¹,

Emmertsen²

1980

Br J Cancer

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Serum angiotensin-converting enzyme (SACE) was analysed in 27 patients with Hodgkin's disease, 25 with non-Hodgkin lymphoma, 14 with acute leukaemia, 15 with chronic leukaemia, and 15 with multiple myeloma. SACE was depressed in these patients as a whole, with a mean level of 19.9 mu/ml, compared with 116 healthy controls (mean 24.4 mu/ml, P < 0.001). This depression was greatest in chronic leukaemia and multiple myeloma. In Hodgkin's disease no relationship was found between enzyme activity and stage, activity, histopathology, treatment, mediastinal involvement or prognosis. In non-Hodgkin patients a poor prognosis was generally associated with low SACE activity. The low SACE activity was not related to recent corticosteroid treatment, and the cause and pathophysiological significance is unexplained. Since SACE is high in the granulomatous disorder sarcoidosis (which can mimic malignant lymphnode and blood diseases) SACE analysis can be valuable in evaluating patients with mediastinal lymphadenopathy and those in whom non-caseating epitheliod granulomas are found.

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Immunofluorescent localization of angiotensin converting enzyme in epithelioid and giant cells of sarcoidosis granulomas.

Cited by 136 publications

References 21 publications

Role of genetic polymorphisms in ACE and TNF-α gene in sarcoidosis: a meta-analysis

Role of genetic polymorphisms in ACE and TNF-α gene in sarcoidosis: a meta-analysis

Angiotensin-converting enzyme and its association with outcome in lung cancer

Serum angiotensin-converting enzyme in malignant lymphomas, leukaemia and multiple myeloma

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