Role of genetic polymorphisms in ACE and TNF-α gene in sarcoidosis: a meta-analysis

Abstract

A great number of association studies have been performed to identify the genes involved in the etiology and prognosis of sarcoidosis. We performed a systematic review of case-control studies through the PubMed database and evaluated them for a possible inclusion into a meta-analysis in order to assess whether the reported genetic polymorphisms are the risk factors of sarcoidosis. Case-control studies with clear diagnostic criteria and interventions were included. Only investigations of a single polymorphism/gene involvement in sarcoidosis reported more than five times were selected. Aggregating data from 12 studies on ID/ACE polymorphisms, the odds ratio (OR) for sarcoidosis, if the polymorphism was considered under the dominant genetic model, was not significantly increased: 1.19 (95% CI 0.98-1.43); OR under the recessive model was 1.20 (95% CI 0.98-1.46). In seven case-control studies on -308/TNF-a polymorphism, the OR for sarcoidosis if the polymorphism considered under the dominant genetic model was significantly increased at 1.47 (95% CI 1.03-2.08); the OR under the recessive model was 1.39 (95% CI 0.67-2.90). In conclusion, the results showed that the TNF-a genotype could be a significant risk factor for sarcoidosis, whereas the risk of sarcoidosis due to the ACE genotype was not substantially elevated.

Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to sarcoidosis: A meta-analysis

“…The results of this meta-analysis differ from those of a previous meta-analysis on the relationship between the ACE I/D polymorphism and sarcoidosis risk performed by Medica et al 39 The present study included four more studies, [13][14][15][16] encompassing 347 more sarcoidosis patients and 345 more controls, than the Medica et al study, and only studies consistent with HWE were included. In addition, an ethnicity-specific meta-analysis was conducted for Europeans and East Asians.…”

Persistent Inactivation of Macrophage Cyclooxygenase-2 in Mycobacterial Pulmonary Inflammation

“…TNF-a is a critical contributor to the granulomatous inflammation of tuberculosis and sarcoidosis (34,35). As shown in Figure 5A, TNF-a production increased on Day 1 after intranasal HK-BCG, and an even larger increase was seen after treatment with HK-P. acnes.…”

ACE gene I/D polymorphism and risk of sarcoidosis development in Turkish patients

“…Sarcoidosis is a chronic systemic granulomatous disease of unknown etiology characterized by accumulation of activated T-lymphocytes and mononuclear phagocytes forming non-caseating epitheloid granuloma in the affected organs (1,2). The recognition of race as an important risk factor clearly suggests a genetic predisposition to develop sarcoidosis.…”