Immunofluorescence Studies in Granuloma Eosinophilicum Faciale

Nieboer, C.; Kalsbeek, G.L.

doi:10.1111/j.1600-0560.1978.tb00940.x

Cited by 42 publications

(25 citation statements)

References 11 publications

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“…Ocorre sobretudo em adultos. [65][66][67][68] O diagnóstico é clínico e histopatológico. São diagnósticos diferenciais os linfomas, pseudolinfomas, sarcoidose, sífilis, lúpus túmido, hanseníase, rosácea granulomatosa e erupção polimorfa à luz.…”

Section: Granuloma Facialunclassified

Vasculites dos médios e grandes vasos

Brandt

Arnone

Valente

et al. 2009

An. Bras. Dermatol.

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Resumo:As vasculites são constituídas por um grande grupo de síndromes caracterizadas por inflamação e necrose da parede dos vasos sangüíneos, resultando em estreitamento ou oclusão do lúmen. A distribuição dos vasos envolvidos varia consideravelmente e serve de base para a classificação das síndromes vasculíticas: grandes vasos (arterite de Takayasu, arterite temporal); pequenos e médios vasos (poliarterite nodosa, síndrome de Churg-Strauss, granulomatose de Wegener, vasculites nas doenças reumáticas); e pequenos vasos (vasculite de hipersensibilidade, púrpura de Henoch-Schonlein, poliangeíte microscópica, crioglobulinemia). Este artigo revisa as vasculites dos médios e grandes vasos e opções terapêuticas atuais; além de oferecer orientação sobre abordagem diagnóstica e tratamento dos pacientes com suspeita de vasculite cutânea. Palavras-chave: Anticorpos anticitoplasma de neutrófilos; Arterite de células gigantes; Arterite de Takayasu; Doenças reumáticas; Granulomatose de Wegener; Poliarterite nodosa; Púrpura; Síndrome de Churg-Strauss; Vasculite; Vasculite alérgica cutânea Abstract: Vasculitis comprises a broad group of syndromes characterized by inflammation and necrosis on the walls of blood vessels, resulting in narrowing or occlusion of the lumen. The distribution of involved blood vessel varies considerably and serves as the basis for one classification of vasculitic syndromes: large vessels (Takayasu arteritis, giant cell arteritis); medium and small muscular arteries (polyarteritis nodosa, Churg-Strauss syndrome, Wegener's granulomatosis, vasculitis in rheumatic diseases); and small vessels ("hypersensitivity" vasculitis, Henoch-Schonlein purpura, microscopic polyangiitis, cryoglobulinemia). This article reviews medium and large vessel vasculitis and current treatment options; it also presents a comprehensive approach to diagnosing and treating patients with suspected cutaneous vasculitis.

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Section: Granuloma Facialunclassified

Vasculites dos médios e grandes vasos

Brandt

Arnone

Valente

et al. 2009

An. Bras. Dermatol.

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“…In der DIF sind granuläre Ablagerungen überwiegend von IgG und C3 sowie reichlich Fibrinogen entlang der dermoepidermalen Junktionszone, um die Haarfollikel und innerhalb der Gefäß-wände zu verzeichnen [20].…”

Section: Granuloma Faciale Und Erythema Elevatum Et Diutinumunclassified

Histologie der kutanen Vaskulitiden

2008

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Identification of vasculitis by skin biopsy represents the diagnostic gold standard. Skin biopsies should be taken from fresh lesions or from margin of an ulceration and should contain all layers of the skin including subcutis. Classification of vasculitis is based on histological criteria considering the size of the predominantly affected vessel, the distribution of vasculitis in the dermis and subcutis, and the predominant inflammatory cell-type. In cutaneous vasculitis, small and medium-sized vessels of the arterial and/or venous system are predominant affected. Vasculitis of the larger-sized blood vessels is based on inflammatory cells within the wall of the vessel; in small vessel vasculitis, additional features include fibrin within the vessel wall and/or an intraluminal thrombus and/or perivascular and interstitial infiltrates of neutrophils, nuclear dust and extravasated erythrocytes are required for the diagnosis of vasculitis. Leukocytoclastic vasculitis is the most common form of cutaneous vasculitis. An correct diagnosis requires careful correlation of medical history, the clinical, serological, imaging and direct immunofluorescence data, and histologic findings.

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“…Das Durchschnittsalter der Patienten betrug 49 Jahre. Das Granuloma eosinophilicum faciei zeichnet auch in der Umgebung der Gefäße [2,13,20].…”

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“…Die Prädilektion von stark lichtexponierter Haut läßt aktinische Vorschädigung als einen ätiopathogenetischen Faktor vermuten [9,11], ist aber nicht bewiesen. Aufgrund der histologischen Befunde wird das Granuloma eosinophilicum faciei heute von vielen Autoren auch als chronische kutane Vaskulitis mit Leukozytoklasie eingeordnet [7,9,13,[20][21][22]. Niebor u. Kalsbeek [13] vermuten eine lokale Hypersensitivitätsvas-kulitis aufgrund einer Antigen-Antikörperreaktion vom Arthus-Typ.…”

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“…Aufgrund der histologischen Befunde wird das Granuloma eosinophilicum faciei heute von vielen Autoren auch als chronische kutane Vaskulitis mit Leukozytoklasie eingeordnet [7,9,13,[20][21][22]. Niebor u. Kalsbeek [13] vermuten eine lokale Hypersensitivitätsvas-kulitis aufgrund einer Antigen-Antikörperreaktion vom Arthus-Typ. Immunphänotypische Studien von Smoller u. Bortz [22] an den lymphozytären Zellen des dermalen Infiltrates zeigen ein fast ausschließliches Vorkommen aktivierter T-Helfer-Zellen und lassen einen Interferon-γ−mediierten Entzün-dungsprozeß vermuten.…”

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