Immunoexpression of <scp>HDAC</scp>1, <scp>HDAC</scp>2, and <scp>HAT</scp>1 in actinic cheilitis and lip squamous cell carcinoma

Chrun, Emanuely Silva; Modolo, Filipe; Vieira, Dsc; Borges-Júnior, Áls; Castro, Renata Goulart; Daniel, Filipe Ivan

doi:10.1111/odi.12641

Cited by 17 publications

(29 citation statements)

References 41 publications

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“…Li et al (2017) have provided evidence supporting that the expression miR-377 is decreased in the tumor and serum of patients with esophageal squamous cell carcinoma (ESCC) and that the lower expression of miR-377 in primary tumor shortened the survival of patients. The overexpression of HAT1 has been evaluated in diverse cancers, which is believed to induce the abnormal transcription of vital genes responsible for regulating major cellular functions including proliferation, cell cycle regulation, and apoptosis (Chrun et al, 2017). regulate the oncogenic and tumor-suppressor genes (Azizi et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐377 exerts a potent suppressive role in osteosarcoma through the involvement of the histone acetyltransferase 1‐mediated Wnt axis

Xia

Zhang

et al. 2019

Journal Cellular Physiology

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It has been demonstrated that microRNAs (miRNAs) may contribute to tumorigenesis and tumor growth in osteosarcoma (OS), which is a primary malignant tumor of bone frequently diagnosed in adolescents and young people. The purpose of our investigation was to evaluate the functional relevance of miR-377 in OS and to investigate whether the mechanism was related to the histone acetyltransferase 1 (HAT1)-mediated Wnt signaling pathway. By screening differentially expressed genes in microarray GSE47572, HAT1 was found to be a candidate gene of interest. Besides, the regulatory miRNA (miR-377) of HAT1 was also selected. The interaction among miR-377, HAT1, and the Wnt signaling pathway was evaluated. In addition, the miR-377 expression was altered in OS cells (U-2OS and SOSP-9607) to assess the in vitro cell apoptosis and the in vivo tumor growth. OS tissues presented elevated HAT1 expression and decreased miR-377 expression. A putative miR-377 binding site in HAT1 3′-UTR HAT1 was verified. Cells with miR-377 overexpression or HAT1 silencing were observed to exhibit reduced HAT1 expression and promoted apoptosis, accompanied by blockade of Wnt signaling. Moreover, the in vivo experiment revealed that miR-377 overexpression or HAT1 silencing inhibited tumor growth and reduced tumor size in nude mice. Taken together, our results conclude that miR-377 may promote OS cell apoptosis through inactivation of the HAT1mediated Wnt signaling pathway, highlighting the potential therapeutic effect of miR-377 on OS treatment.

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Section: Discussionmentioning

confidence: 99%

MicroRNA‐377 exerts a potent suppressive role in osteosarcoma through the involvement of the histone acetyltransferase 1‐mediated Wnt axis

Xia

Zhang

et al. 2019

Journal Cellular Physiology

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“…Oral squamous cell carcinoma HDAC1 overexpression was found in 55.10% of 49 mobile tongue squamous cell carcinoma evaluated whereas most of the cells from non-neoplastic epithelium presents negative immunoexpression for HDAC1 (Theocharis, et al 2011). HDAC1 was overexpressed in 70% of lip squamous cell carcinoma ( Fig.2) and in 77% of actinic cheilitis, with immunoexpression increasing in preneoplastic cases with severe epithelial dysplasia, and in neoplastic cases with poor differentiation (Chrun, et al 2017).…”

Section: Implicated Inmentioning

confidence: 96%

HDAC1 (histone deacetylase 1)

Chrun¹,

Modolo²,

Daniel³

2018

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HDAC1 is a Class I histone deacetylase (HDACs) encoded by this gene. HDACs remove acetyl group from amino-terminal tail of histone lysine recovering the positive charge of histone tail, permitting interactions between negatively charged DNA and histone protein, resulting in chromatin structure condensation which is associated with gene repression. Overexpression of this protein has been related to several malignancies, controlling tumour suppressor genes expression, feasible prognostics factor, and medications target. This paper propound data about HDAC1 gene, its protein encoded and function.

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“…A notable amount of research has been performed regarding HDACs' clinical significance in oral cancer and less in nasopharyngeal cancer and salivary gland tumors [12][13][14][15][16][17][18][19][20][21] (Table 2). HDAC-2 was found to be overexpressed in the majority of cases with epithelial dysplasia and oral squamous cell carcinoma (SCC) without, however, showing any noteworthy correlation with sex, age or oral habits in those patients [20].…”

Section: Nasopharyngeal Cancer Salivary Glands and Oral Cancermentioning

confidence: 99%

Unraveling the Epigenetic Role and Clinical Impact of Histone Deacetylases in Neoplasia

2021

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Histone deacetylases (HDACs) have long been implicated in tumorigenesis and tumor progression demonstrating their important participation in neoplasia. Therefore, numerous studies have been performed, highlighting the mechanism of HDACs action in tumor cells and demonstrating the potential role of HDAC inhibitors in the treatment of different cancer types. The outcome of these studies further delineated and strengthened the solid role that HDACs and epigenetic modifications exert in neoplasia. These results have spread promise regarding the potential use of HDACs as prospective therapeutic targets. Nevertheless, the clinical significance of HDAC expression and their use as biomarkers in cancer has not been extensively elucidated. The aim of our study is to emphasize the clinical significance of HDAC isoforms expression in different tumor types and the correlations noted between the clinicopathological parameters of tumors and patient outcomes. We further discuss the obstacles that the next generation HDAC inhibitors need to overcome, for them to become more potent.

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Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma

Abstract: This study showed higher levels of nuclear HDAC2 immunopositivity in AC, possibly indicating that this enzyme plays a key role in lip photocarcinogenesis early stages.

Cited by 17 publications

References 41 publications

MicroRNA‐377 exerts a potent suppressive role in osteosarcoma through the involvement of the histone acetyltransferase 1‐mediated Wnt axis

MicroRNA‐377 exerts a potent suppressive role in osteosarcoma through the involvement of the histone acetyltransferase 1‐mediated Wnt axis

HDAC1 (histone deacetylase 1)

Unraveling the Epigenetic Role and Clinical Impact of Histone Deacetylases in Neoplasia

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