Immunoexpression of Ki67, proliferative cell nuclear antigen, and Bcl-2 proteins in a case of ameloblastic fibrosarcoma

Pontes, Hélder Antônio Rebelo; Pontes, Flávia Sirotheau Corrêa; Silva, Brunno Santos de Freitas; Cury, Sérgio Elias Vieira; Fonseca, Felipe Paiva; Salim, Rodrigo Alves; Pinto, Décio dos Santos

doi:10.1016/j.anndiagpath.2009.10.007

Cited by 29 publications

(33 citation statements)

References 15 publications

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“…When Ki-67 was quantified, positivity rates ranged from 13.5% to 60.0% for the malignant mesenchymal component. Although no established cutoff value for Ki-67 positivity has been reported in the literature, the present case is within the interval of Ki-67 expressed in malignant lesions (~20.0%), suggesting that proliferative factors, in association with histopathological features, may be useful markers for the identification of malignant cases (4,5,69,79,88,89,113).…”

Section: Discussionmentioning

confidence: 90%

“…Immunohistochemical studies may facilitate diagnosis of these lesions, given that Ki-67, PCNA and p53 were found expressed at higher levels within the sarcomatous component of the AFS, whereas they are absent or expressed at lower levels in AF (5,12,62,69,79,89,101,113,123). Results obtained from several papers (4,5,69,79,82,88,89,113) revealed that Ki-67 was overexpressed (highly diffuse positivity) in the malignant mesenchymal portion of AFS, compared with AF.…”

Section: Discussionmentioning

confidence: 98%

“…Results obtained from several papers (4,5,69,79,82,88,89,113) revealed that Ki-67 was overexpressed (highly diffuse positivity) in the malignant mesenchymal portion of AFS, compared with AF. When Ki-67 was quantified, positivity rates ranged from 13.5% to 60.0% for the malignant mesenchymal component.…”

Section: Discussionmentioning

confidence: 99%

“…(4-6,9-13,16-113). Papers describing clinicopathological features similar to those described for AFS were included in the first instance (4,5,(9)(10)(11)(12)(13)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(28)(29)(30)32,(34)(35)(36)(37)(38)(39)42,43,(67)(68)(69)(70)(71)(72)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)91,…”

Section: Systematic Literature Reviewmentioning

confidence: 99%

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Ameloblastic Fibrosarcoma: A Case Report and Literature Review

et al. 2017

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Here is described a case of ameloblastic fibrosarcoma (AFS) affecting the posterior mandible of a woman who was treated surgically and recovered without signs of recurrence or metastasis after 12 years of follow-up. Tumor sections were immunostained for cell cycle, epithelial and mesenchymal markers. Immunohistochemical analysis evidenced high Ki-67 positivity in stromal cells (mean of 20.9 cells/High power field). Epithelial cells displayed strong positivity for p53, p63 and cytokeratin 19. In addition to the case report, a systematic review of current knowledge is presented on the AFS's clinical-demographic features and prognostic factors. Based on the review, 88/99 cases were diagnosed as AFS, 9/99 as ameloblastic fibro-odontosarcoma and 2/99 as ameloblastic fibrodentinosarcoma. All these lesions displayed very similar clinical-demographic and prognostic features. Moreover, the review provided evidence that first treatment, regional metastasis, distant metastasis and local recurrence were significant prognostic values for malignant odontogenic mesenchymal lesions. Based on the findings, segregation among ameloblastic fibrosarcoma, ameloblastic fibrodentinosarcoma and ameloblastic fibro-odontosarcoma seems illogical, considering all these lesions have similar predilections and outcomes.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Systematic Literature Reviewmentioning

confidence: 99%

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Ameloblastic Fibrosarcoma: A Case Report and Literature Review

et al. 2017

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“…2,9 An overexpression of Ki-67 immunoexpression (a proliferative nuclear cell marker) and Bcl-2 proteins in AFS, in association with histopathological features, may be useful markers to identify malignancy. 9 Regarding the nature and biological behavior of tumors, the treatment for AF in 90% of the cases initially consists of a conservative surgical approach, and in 10% of the cases, radical surgery. 4 The most appropriate treatment for AF is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Ameloblastic fibroma: a case report

et al. 2015

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| Ameloblastic fibroma is a rare benign odontogenic tumor in which both epithelial and ectomesenchymal components are neoplastic. A 24-year-old male patient was referred to the Stomatology Department with difficulty to chew and swelling in the right posterior region of the mandible. The panoramic radiograph showed a well-circumscribed, unilocular radiolucent lesion with partially radiopaque borders involving first and second unerupted molars. Computed tomography imaging presented a hypodense image with well-delimited isodense content, bulging and rupture of cortical bones. The patient underwent an incisional biopsy. Microscopically, the lesion was composed of many mesenchymal tissue cells in strand form, arranged in cords, islands and nests of odontogenic epithelium; the diagnostic was ameloblastic fibroma. The patient was referred to the hospital for enucleation and curettage of the lesion and extraction of the associated teeth. After 8 months of follow-up, no recurrence was observed. This case emphasizes the importance of differential diagnosis, anatomopathological exam, and both clinical and imaging follow-up, since this kind of tumor can recur and progress to malignancy. DESCRIPTORS | Odontogenic Tumors; Oral Pathology; Ameloblastic Fibroma. RESUMO | Fibroma ameloblástico: um estudo de caso • O fibroma ameloblástico é um tumor odontogênico benigno raro no qual os componentes epiteliais e ectomesenquimais são neoplásicos. Paciente de 24 anos de idade foi encaminhado à clínica de Estomatologia devido à dificuldade de mastigar e edema na região posterior direita da mandíbula. A radiografia panorâmica evidenciou uma lesão radiolúcida unilocular, circunscrita, com bordas parcialmente radiopacas envolvendo o primeiro e segundo molar não irrompidos. A tomografia computadorizada apresentou imagem hipodensa, com conteúdo isodenso, bem delimitada, com abaulamento e rompimento das corticais ósseas. O paciente foi submetido a uma biópsia incisional. Microscopicamente, a lesão foi composta por tecido mesenquimal rico em células, formando cordões, ilhas e ninhos de epitélio odontogênico, cujo diagnóstico foi de fibroma ameloblástico. O paciente foi encaminhado ao hospital para enucleação e curetagem da lesão com extração dos dentes associados. Após 8 meses de acompanhamento, não se observou recorrência. Este caso enfatiza a importância do diagnóstico diferencial, exame anatomopatológico, e acompanhamento clínico e radiográfico, uma vez que este tumor pode recidivar e evoluir para malignidade.

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Ameloblastic Fibrosarcoma

2016

Diagnostic Pathology: Head and Neck

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Immunoexpression of Ki67, proliferative cell nuclear antigen, and Bcl-2 proteins in a case of ameloblastic fibrosarcoma

Cited by 29 publications

References 15 publications

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

Ameloblastic fibroma: a case report

Ameloblastic Fibrosarcoma

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