Immunocytochemical localization of piscidin in mast cells of infected seabass gill

Exposure of sea bream (Sparus aurata) to toxic concentrations of benzo[a]pyrene: possible human health effect

“…These data confirm the immunotoxic action of B[a]P and the involvement of rodlet and mast cells in B[a]P-induced inflammatory response (Dezfuli et al, 2010, Quabius et al, 2005, Lauriano et al, 2012. In fact, organic pollutants have been reported to induce proliferation of mucous cells, mast cells and rodlet cells in fish immune system (Dezfuli et al, 2010, Quabius et al, 2005, Lauriano et al, 2012. Mast cells, also known as eosinophilic granular cells, are considered to be a component of the teleost innate immune system and have been observed in regions of active inflammatory responses, including gut, gills, skin, brain, in the vicinity of blood vessels (Reite and Evensen 2006;Murray et al, 2007); they play an important role also in the mechanisms of inflammatory response linked to a wide range of stressful conditions, such as exposure to xenobiotics (Lauriano et al, 2012).…”

“…Furthermore, an increase of CYP1A-positive mast cells was observed in the connective tissue surrounding the central cartilage of the gill filaments (Fig.2). These data confirm the immunotoxic action of B[a]P and the involvement of rodlet and mast cells in B[a]P-induced inflammatory response (Dezfuli et al, 2010, Quabius et al, 2005, Lauriano et al, 2012. In fact, organic pollutants have been reported to induce proliferation of mucous cells, mast cells and rodlet cells in fish immune system (Dezfuli et al, 2010, Quabius et al, 2005, Lauriano et al, 2012.…”

Mast cell responses to Ergasilus (Copepoda), a gill ectoparasite of sea bream

“…Piscidins are the prototypical AMP present in piscine MCs [16,21e23,27,29e31]. Piscidins have potent, broad-spectrum antibacterial and antifungal activity and have strong antiparasitic activity [16,21,27]. With regard to their mechanism of action, piscidins are thought to inhibit the synthesis of the cell wall, nucleic acids, and proteins or even inhibit enzymatic activity [32].…”

Molecular characterization of two isoforms of piscidin 4 from the hybrid striped bass (Morone chrysops × Morone saxatilis)

“…Along with the three other piscidins isolated from hybrid striped bass, piscidin 4 shares a conserved N-terminal domain rich in histidine and phenylalanine. Originally isolated from striped bass, white bass, and their hybrid [5,6], there is evidence that piscidins are present in a wide range of teleost taxa, including the families Moronidae, Sciaenidae, Siganidae, Belontidae, Cichlidae, Percichthyidae [5,7] and Latridae [8]. The chrysophsins, antimicrobial peptides isolated from red sea bream (Chrysophrys major), a member of the family Sparidae, are also similar to the piscidins [9].…”