Immunocytochemical localization of neurons expressing 5-HT-moduline in the mouse brain

The Relationship BetweenSerotonin Receptor 1B Polymorphisms A‐161Tand Alcohol Dependence

“…Clark and Neumaier (2001) suggested that reduced 5HT1B autoreceptor activity may have an antidepressant‐like effect. 5HT1B autoreceptors are localized on serotonergic neuron terminals, where they inhibit the evoked release of serotonin and its biosynthesis (Fink et al., 1995; Griebel, 1995;Grimaldi et al., 1997; Hjorth et al., 1995). Hjorth and Tao (1991) reported that 5HT1B autoreceptors mediate the feedback control of serotonin release in the rat brain, a mechanism that presumably prevents the over‐stimulation of postsynaptic serotonin receptors.…”

Circadian variation in the activity of the 5‐HT1B autoreceptor in the region of the suprachiasmatic nucleus, measured by microdialysis in the conscious freely‐moving rat

“…This molecule specifically inhibited the binding of tritiated 5‐HT to 5‐HT 1B receptors, thus acting as an allosteric modulator at the 5‐HT 1B site, and was shown in behavioural experiments to have an antagonistic effect on 5‐HT 1B receptor activity. Since that time, 5‐HT moduline has been localized immunocytochemically in rodent brain after an antibody was raised against the peptide ( Grimaldi et al ., 1997 ). Localization of 5‐HT moduline appeared to overlap binding at 5‐HT 1B receptors, giving strength to the suggestion that it specifically interacts with 5‐HT 1B receptors.…”

5‐HT moduline: an endogenous inhibitor of 5‐HT1B/1D‐mediated contraction in pulmonary arteries

“…5‐HT moduline (5‐HTm, Leu‐Ser‐Ala‐Leu) was originally isolated from rat brain (Rousselle et al ., 1996) and acts as a specific endogenous antagonist to central 5‐HT 1B/1D receptors with a high affinity ( K D =0.2–0.8 n M ) (Massot et al ., 1996). Centrally, immunocytochemical studies have shown that 5‐HTm is heterogenously distributed in neuronal structures of the brain and is associated with the 5‐HT 1B/1D receptor (Grimaldi et al ., 1997). Binding of 5‐HTm is absent in the brains of 5‐HT 1B knockout mice (Cloez‐Tayarani et al ., 1997).…”