The Relationship BetweenSerotonin Receptor 1B Polymorphisms A‐161Tand Alcohol Dependence

Abstract

This study suggests that the 5HT1B gene A-161T polymorphism alone is not a risk factor for increasing susceptibility to either AD or its subtypes. However, 5HT1B gene A-161T polymorphisms might be one of the common genetic factors between the ANX/DEP ALC and antisocial ALC subgroups.

Association of the DRD2 TaqIA, 5-HT1B A-161T, and CNR1 1359 G/A Polymorphisms with Alcohol Dependence

“…In agreement with this finding, we also found an association between alcohol dependence and the A-161T polymorphism in the present study. In contrast to these results, two papers from the literature have reported no association between alcohol dependence and the A-161T polymorphism 33,34 . We investigated the possibility of an association between the rs1049353 polymorphism of CNR1 and alcohol dependence, but failed to detect any difference between the alcohol-dependent and control groups in the present study.…”

Associations of the 5‐hydroxytryptamine (serotonin) Receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse

“…In the end, 18 studies, composed of 17 case-control (Cao and others 2011; Cigler and others 2001; Contini and others 2012; Gao and others 2011; Hasegawa and others 2002; Lee and others 2009; Proudnikov and others 2006; Sander and others 2000; Sun and others 2002; Ujike and others 2011; Wang and others 2012; Yuan and others 2005) and one HRR study (Hill and others 2002), met our criteria for inclusion. These studies included four studies for European populations (Cigler and others 2001; Hill and others 2002; Proudnikov and others 2006; Sander and others 2000), three studies for Hispanic subjects (Cigler and others 2001; Contini and others 2012; Proudnikov and others 2006), two studies for African Americans (Cigler and others 2001; Proudnikov and others 2006), and nine for Asian populations (Cao and others 2011; Gao and others 2011; Hasegawa and others 2002; Lee and others 2009; Proudnikov and others 2006; Sun and others 2002; Ujike and others 2011; Wang and others 2012; Yuan and others 2005). One study (Cigler and others 2001) included data from three populations and one study (Proudnikov and others 2006) included data from four populations.…”

“…These patients were diagnosed as alcohol, cocaine, methamphetamine, and (or) heroin dependence (or abuse). Among the 18 studies, six studies (Gao and others 2011; Proudnikov and others 2006; Yuan and others 2005) investigated heroin dependence or abuse; one study (Ujike and others 2011) investigated methamphetamine dependence; three studies (Cigler and others 2001) investigated cocaine and (or) alcohol dependence or abuse, or both; and the other eight studies (Cao and others 2011; Contini and others 2012; Hasegawa and others 2002; Hill and others 2002; Lee and others 2009; Sander and others 2000; Sun and others 2002; Wang and others 2012) investigated alcohol dependence or abuse. The demography of the combined studies is shown in supplementary Table 1.…”

“…The HTR1B SNPs were reported to play important roles in alcohol and drug dependence and psychiatric disorders. For example, for -161A>T, three studies (Cao and others 2011; Cigler and others 2001; Sun and others 2002) showed significant associations while no evidence was found in other studies (Cigler and others 2001; Contini and others 2012; Lee and others 2009; Proudnikov and others 2006; Ujike and others 2011); for 1180G>A, the G allele was reported to be associated with heroin addiction with a protective effect in Caucasians (Proudnikov and others 2006), however, other studies (Gao and others 2011; Sun and others 2002; Ujike and others 2011) implied inconsistent results.…”

Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development

“…In particular, cocaine- and amphetamine-dependent patients often exhibit co-morbidity for alcohol and opiate abuse (Leri et al, 2003; Miller et al, 1993; Prinzleve et al, 2004), as well as mood and anxiety disorders (NIDA Research Report Series: Comorbidity). Interestingly, polymorphisms of 5-HT 1B Rs have been linked to substance abuse not only for cocaine, but also opiates and alcohol (Cao et al, 2011; Huang et al, 2003; Lee et al, 2009; Proudnikov et al, 2006; Sun et al, 2002). Neuroimaging studies in humans have also revealed that alcohol dependence is associated with increased levels of ventral striatal 5-HT 1B Rs (Hu et al, 2010), effects similar to those detected following cocaine administration in rats (Hoplight et al, 2007; Neumaier et al, 2009).…”