2020
DOI: 10.1007/s00418-020-01937-y
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Immunocytochemical assessment of cell differentiation of podoplanin-positive osteoblasts into osteocytes in murine bone

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Cited by 8 publications
(4 citation statements)
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“…The lymph node expansion causes by the reduction of podoplanin-mediated contraction in inflamed lymph nodes where mature dendritic cells interact with fibroblastic reticular cells via podoplanin-CLEC-2 binding [21][22][23][24] . There is a detailed report on the expression of podoplanin in bone cells 25) . It shows that the CD44-podoplanin binding contributes to the osteoblast differentiation in the remodeling sites but not in modeling sites of bone.…”
Section: Introductionmentioning
confidence: 99%
“…The lymph node expansion causes by the reduction of podoplanin-mediated contraction in inflamed lymph nodes where mature dendritic cells interact with fibroblastic reticular cells via podoplanin-CLEC-2 binding [21][22][23][24] . There is a detailed report on the expression of podoplanin in bone cells 25) . It shows that the CD44-podoplanin binding contributes to the osteoblast differentiation in the remodeling sites but not in modeling sites of bone.…”
Section: Introductionmentioning
confidence: 99%
“…Osteoblasts secrete bone matrix proteins and can become embedded in the bone matrix, where they differentiate into osteocytes. Immediately before becoming embedded into the bone matrix, osteoblasts rearrange the actin filament assembly along the cell membranes and the cytoplasmic processes, which resemble that of embedded osteocytes [ 24 ]. This implies that the osteoblasts approaching osteocytic differentiation and the newly-differentiated osteocytes decide the geometrical structure of the cellular network of their cytoplasmic processes.…”
Section: Osteocyte Network and The Biological Function Of Regulating ...mentioning
confidence: 99%
“…After primary mineralization, the bone mineral density becomes slowly and chronologically elevated in a phenomenon called secondary mineralization, which is independent of osteoblastic bone formation [ 2 ]. It is hypothesized that secondary mineralization is achieved by the physicochemical processes of mineral transport in the osteocytic network extended throughout the bone [ 24 ]. Therefore, the osteocytes and the meshwork of their cytoplasmic processes appear essential for secondary mineralization involving bone mineral transportation [ 25 , 26 , 27 , 28 ].…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, osteoblasts interacting through the OLCS can undergo further differentiation into osteocytes, comprising approximately 90-95% of all bone cells (Florencio-Silva et al 2015). This has prompted Nagai et al (2021) to perform a detailed multi-immunohistochemical analysis, combined with pre-embedding peroxidase immunoelectron microscopy to investigate the process of late-stage osteoblast differentiation into osteocytes. They chose to combine immunostaining for podoplanin, a transmembrane glycoprotein expressed in late-stage osteoblasts and pre-osteocytes, together with some of its purported binding partners.…”
Section: A Bone To Pick…mentioning
confidence: 99%