2023
DOI: 10.2485/jhtb.32.213
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Morphological Study for the Osteocytes in Podoplanin-Conditional Knockout Mice

Kyoko Osawa,
Takenori Kanai,
Natsumi Ushijima
et al.

Abstract: We generated podoplanin-conditional knockout mice where the floxed podoplanin exon3 was deleted by the Dmp-1-driven Cre (Dmp1-Cre;Pdpn Δ/Δ ) and investigated the cell process elongation of podoplanin-deficient mouse osteocyte in vitro and in vivo. The expression of podoplanin is found in odontoblasts while not observed in odontoblasts of Dmp1-Cre; Pdpn Δ/Δ mice, indicating that the conditional knockout of podoplanin in Dmp1-expressing cells in Dmp1-Cre;Pdpn Δ/Δ mice is successful. There were no differences in … Show more

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