Immunocorrecting effect of glucosamine-muramylpeptide in cases of bronchial asthma in children

Титова, Н. Д.; Novikova, V. I.

doi:10.14427/jipai.2017.1.31

Cited by 2 publications

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“…As was earlier reported, the immunotropic effects of glucoseminylmuramildipeptide include intensification of macrophages' activity, activation of T-cells and B-cells, and in combination with basic anti-inflammatory therapy in patients with BA increase of allergen tolerance and stimulation of immunity are observed. One of significant immunotropic effects of glucoseminylmuramildipeptide as a part of therapy for asthma is changing of the profile of cytokines being synthesized from pro-inflammatory allergic one (IL-4, TNFα, IL-5) to anti-inflammatory (IFNγ, IL-2), most probably, due to stimulation of Th1 as opposed to Th2 [14].…”

Section: Resultsmentioning

confidence: 99%

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Characteristics of Immunocompetent Cells in Children With Allergen-Induced Phenotype of Bronchial Asthma Treated With Glucoseminylmuramildipeptide

2021

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Purpose: to study the changes in quantitative values and functional activity of immunocompetent cells on application of glucoseminylmuramildipeptide in children with allergen-induced phenotype of bronchial asthma.We have performed an integrated assessment of parameters of innate and acquired immunity in 60 children at the age of 3-11 years old with allergen-induced bronchial asthma (BA) with mild clinical course of disease, and in 30 healthy children of the same age. BA phenotypes were verified in accordance with PRACTALL international consensus report (2008). Study exclusion criteria were: severe course of bronchial asthma and application of immunocorrecting therapy during preceding six months. We conducted a prospective parallel open study of the effect of glucoseminylmuramildipeptide on the parameters of immunocompetent cells during three months with division into two control groups by random sampling technique on the basis of therapy being performed. To analyze the venous blood cells, we used flow cytofluorometer COULTER EPICS XL by Beckman Coulter Inc. Cytokine levels were determined using immunoenzyme method with reagents by R&D Diagnostics Inc (USA) and IgE – with reagents by Alkor Bio Company (St. Petersburg), production of cytokines – using reagents by Vektor-Best (Novosibirsk). Statistical processing of data was performed using Statistica 10 program with significance level p < 0.05, assessment of correlations by Spearman correlation analysis, multidimensional correlation analysis with V.P. Terentyev’s method of correlation pleiades (1959) and testing for normal distribution of characteristic values (Shapiro–Wilk). The scope of our study permitted to evaluate its findings with accuracy 95-99%.The changes of the adaptive response system in children with allergen-induced phenotype of BA were characterized by the intensified proliferation, suppression of negative regulation processes, activation of synthesis of Th2-profile cytokines, and intensified synthesis of IgE.The identified impairments of availability, functional activity of immunocompetent cells and cytokine production were preserved in application of inhaled corticosteroids therapy, with further decreasing of IFNγ synthesis.Application of glucoseminylmuramildipeptide in children with BA provided for reduction of spontaneous and mitogen-induced production of IL-4 and correction of deviated structural and functional characteristics of immunocompetent cells.Incorporation of glucoseminylmuramildipeptide into therapeutic regimens for allergen-induced phenotype of BA in children promoted normalization of parameters of the cellular component of immune system, amelioration of Th1/Th2-imbalance, increase of Th1 activity, and adequate spontaneous and induced production of IFNγ by peripheral blood cells.

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Section: Resultsmentioning

confidence: 99%

“…In their studies, N.D. amelioration of cytokine production imbalance and increase of allergen tolerance [14].…”

Section: Resultsmentioning

confidence: 99%

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Characteristics of Immunocompetent Cells in Children With Allergen-Induced Phenotype of Bronchial Asthma Treated With Glucoseminylmuramildipeptide

2021

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Immune Mechanisms for Development of Controlled and Partially Controlled Asthma

et al. 2019

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Despite a significant amount of works specifying immune mechanisms of bronchial asthma (BA), different phenotypes observed in this pathology need to be studied. The aim of present study was to analyze functional activity of Th1, Th2 и Th17 lymphocytes, and to determine features of inflammation in controlled and partly controlled asthma.We examined eighty-four BA patients that were divided into 2 groups, depending on the control of symptoms and the clinical course of BA. Group I included 45 patients with controlled BA, whereas group II included 39 patients with partially controlled asthma. The subsets of Th1, Th2, and Th17 lymphocytes were assessed by serum cytokine levels (TNFα, IFNγ, IL-2, IL-4, IL-6, IL-10, IL-17A) using flow cytometry technique.The results of this study were as follows: we have shown a combined T-helper (Th) immune response in asthma patients, with its origin depending on the degree of the disease control. Th2 (62%), Th1/Th2 (20%) and Th1 (18%) types of immune response have been detected in the patients with controlled BA. Th2/Th17 (49%), Th1/Th17 (13%) and Th17 (37%) types of immune response have been identified in the patients with partially controlled BA. It has been shown, that Th1 immune response in patients with controlled asthma is induced by intracellular infection. The formation of the Th1/Th2 phenotype is associated with a site of chronic bacterial infection revealed, and with persistence of viral infection in the body. This phenotype can be used as an indicator of asthma worsening. Further studies in the role of prevalent immune response type in the development of partially controlled BA have shown that activation of Th17 lymphocytes is associated with prolonged course of the disease. Irrespectively of initial phenotype, the development of Th17-dependent immune response seems to result from a durable systemic persistent inflammation.The views on the key role of Th1/Th2 balance in the development of asthma are accomplished by evidence of Th17 lymphocyte involvement into the process, and Th1/Th17, Th2/Th17 phenotypes seem to be the polar features of the disease. Estimation of intensity and phenotype of inflammation in BA will permit a more objective evaluation of the therapy applied, and to choose further management strategies.

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Immunocorrecting effect of glucosamine-muramylpeptide in cases of bronchial asthma in children

Cited by 2 publications

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Characteristics of Immunocompetent Cells in Children With Allergen-Induced Phenotype of Bronchial Asthma Treated With Glucoseminylmuramildipeptide

Characteristics of Immunocompetent Cells in Children With Allergen-Induced Phenotype of Bronchial Asthma Treated With Glucoseminylmuramildipeptide

Immune Mechanisms for Development of Controlled and Partially Controlled Asthma

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