Immunocompetence of Patients with Protein-Calorie Malnutrition

Law, Dennis K. S.; Dudrick, Stanley J.; Abdou, Nabih I.

doi:10.7326/0003-4819-79-4-545

Cited by 374 publications

(71 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…17) Law, et al have reported that both the T and B systems were impaired in adults with moderate protein calorie malnutrition, and it was restored by nutritional repletion. 18) Study limitations: The total number of patients enrolled in the ICAS-HF registry and the number of in-hospital death events were not large. Therefore, the number of indices that could be incorporated into the logistic analysis models was small.…”

Section: Discussionmentioning

confidence: 99%

Utility of Nutritional Screening in Predicting Short-Term Prognosis of Heart Failure Patients

et al. 2018

View full text Add to dashboard Cite

SummaryControlling nutritional status (CONUT) uses 2 biochemical parameters (serum albumin and cholesterol level), and 1 immune parameter (total lymphocyte count) to assess nutritional status. This study examined if CONUT could predict the short-term prognosis of heart failure (HF) patients.A total of 482 (57.5%) HF patients from the Ibaraki Cardiovascular Assessment Study-HF (n = 838) were enrolled (298 men, 71.7 ± 13.6 years). Blood samples were collected at admission, and nutritional status was assessed using CONUT. CONUT scores were defined as follows: 0-1, normal; 2-4, light; 5-8, moderate; and 9-12, severe degree of undernutrition. Accordingly, 352 (73%) patients had light-to-severe nutritional disturbances. The logarithmically transformed plasma brain natriuretic peptide (log BNP) concentration was significantly higher in the moderate-severe nutritional disturbance group (2.92 ± 0.42) compared to the normal group (2.72 ± 0.45, P < 0.01). CONUT scores were significantly higher in the in-hospital death patients [4 (3-8), n = 14] compared with patients who were discharged following symptom alleviation [3 (1-5), n = 446, P < 0.05]. With the exception of transferred HF patients (n = 22), logistic regression analysis that incorporated the CONUT score and the log BNP, showed that a higher CONUT score (P = 0.019) and higher log BNP (P = 0.009) were predictors of in-hospital death, and the median duration of hospital stay was 20 days.Our results demonstrate the usefulness of CONUT scores as predictors of short-term prognosis in hospitalized HF patients.(Int Heart J Advance Publication)

show abstract

Section: Discussionmentioning

confidence: 99%

Utility of Nutritional Screening in Predicting Short-Term Prognosis of Heart Failure Patients

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Defects in humoral immunity, mucosal immunity and phagocytic cell function have been identified, but the weight of evidence suggests that cell-mediated immunity is most profoundly impaired (Law et al, 1973;Keusch et al, 1978;Gross & Newberne, 1980;Martin et al, 1983;Chandra, 1989). In particular, depressed NK activity and unresponsiveness to interferon have been reported in PBMC of infants with PCM, as well as in acute starvation (Salimonou et al, 1983;Schattner et al, 1990).…”

mentioning

confidence: 99%

Reduced natural killer cell activity and IL-2 production in malnourished cancer patients

Villa¹,

Ferrario²,

Bergamasco³

et al. 1991

Br J Cancer

View full text Add to dashboard Cite

“…The correlation of depression of monocyte maturation with extent of disease raises the question whether increasing metabolic disturbance and general debility underlie the abnormality. Such disturbances may be associated with abnormalities of immune function (Smythe et al, 1971;Law et al, 1973) and macrophage killing of micro-organisms (Olson et al, 1978). However, although this may be partly the cause it is unlikely to be the sole explanation.…”

Section: Discussionmentioning

confidence: 99%

In vitro monocyte maturation in squamous carcinoma of the lung

Dent¹,

Cole²

1981

Br J Cancer

View full text Add to dashboard Cite

Maturation of monocytes into macrophages in vitro has been assayed by a quantitative microtitre assay in patients with squamous-cell carcinoma of the lung. Monocyte maturation in autologous serum was significantly depressed in patients with both limited and extensive disease compared with normal controls, patients with chronic obstructive airways disease and controls matched for age, sex, smoking history, respiratory function and the presence of infection. Maturation of monocytes from patients with terminal non-malignant disease was depressed, though not to the same extent as in those with extensive malignancy. Monocytes from relatives of patients with squamous-cell carcinoma of the lung matured normally. In 10 patients with limited disease, in vitro monocyte maturation was repeated 6-12 weeks after operation, and was found to relate to prognosis.

show abstract

Immunocompetence of Patients with Protein-Calorie Malnutrition

Cited by 374 publications

References 10 publications

Utility of Nutritional Screening in Predicting Short-Term Prognosis of Heart Failure Patients

Utility of Nutritional Screening in Predicting Short-Term Prognosis of Heart Failure Patients

Reduced natural killer cell activity and IL-2 production in malnourished cancer patients

In vitro monocyte maturation in squamous carcinoma of the lung

Contact Info

Product

Resources

About