Immunochemical quantitation of fatty acid-binding proteins. Tissue distribution of liver and heart FABP types in human and porcine tissues

Paulussen, R. J. A.; Moerkerk, H.T.B. van; Veerkam, Jacques H.

doi:10.1016/0020-711x(90)90142-p

Cited by 68 publications

(32 citation statements)

References 40 publications

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“…The presence of physiologically significant concentrations of FABP in the cytoplasm of muscle endothelial cells, however, is a matter of continuous debate. In cardiac endothelium, several investigators have reported the presence of a substantial amount of FABP, ranging from 8-26 JLg/mg cytosolic protein (80,209). These findings could not be confirmed by studies performed in our laboratory using sensitive and specific biochemical, molecular biological, and immunohistochemical techniques (163,294).…”

Section: Skeletal Muscle Fatty Acid Uptakecontrasting

confidence: 72%

“…In this respect it is also note- worthy that insect flight muscles, being among the most active muscles known and heavily depending on fatty acid oxidation for energy conversion, contain very large amounts of FABP (113,290). Human heart and skeletal muscles contain generally lower amounts of FABP than comparable types of tissue in rat (208,209).…”

Section: Skeletal Muscle Fatty Acid Uptakementioning

confidence: 96%

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Lipid Metabolism in Muscle

Vusse

Reneman

1996

Comprehensive Physiology

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The sections in this article are: Supply and Cellular Uptake of Upids in Skeletal Muscles Albumin‐Bound Fatty Acids Fatty Acids in Circulating Lipoproteins Skeletal Muscle Fatty Acid Uptake Fatty Acid Metabolism in the Skeletal Muscle Cell Activation and Oxidation of Fatty Acids Intramuscular Triacylglycerols Supply and Utilization of Upids During Exercise Albumin‐Bound Fatty Acids in Plasma during Exercise Circulating Lipoprotein‐Triacylglycerols as a Potential Source of Fatty Acids during Exercise Contribution of Intramuscular Triacylglycerols to Fatty Acid Oxidation during Exercise Relative Contribution of Various Sources of Lipids to Overall Fatty Acid Utilization during Exercise Gender Differences in Lipid Utilization during Exercise Effect of Training on Skeletal Muscle Lipid Utilization Advantages of Enhanced Lipid Utilization by Trained Muscles during Exercise Possible Causes of Increased Lipid Consumption by Trained Muscles during Exercise Utilization of Plasma‐Borne Fatty Acids by Trained Muscles Circulating Lipoproteins as an Additional Source of Lipids for Trained Muscles Utilization of Intramuscular Triacylglycerols in Endurance‐Trained Muscles Regulation of Fatty Acid Release from Intramuscular Triacylglycerols in Trained Muscles Effect of Diet on Muscle Lipid Metabolism High‐Carbohydrate vs. High‐Fat Diets in Relation to Physical Performance Shift from Carbohydrate to Lipid Utilization by High‐Fat Diet Source of Lipid for Muscles during High‐Fat Diet Feeding Possible Mechanisms Underlying Increased Muscular Lipid Utilization during High‐Fat Feeding Interrelationship Between Muscular Carbohydrate and Lipid Metabolism The Glucose–Fatty Acid, or Randle, Cycle The Existence of the Randle Cycle in Skeletal Muscle Possible Mechanisms Underlying the Glucose‐Fatty Acid Cycle in Skeletal Muscle A Role for Malonyl CoA in Fuel Selection in Skeletal Muscle Cells Defects in the Skeletal Muscle Fatty Acid Oxidative Pathway Concluding Remarks

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Section: Skeletal Muscle Fatty Acid Uptakecontrasting

confidence: 72%

Section: Skeletal Muscle Fatty Acid Uptakementioning

confidence: 96%

Lipid Metabolism in Muscle

Vusse

Reneman

1996

Comprehensive Physiology

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“…SDS/PAGE and immunoblotting were carried out as described (Di Pietro and SantomC, 1996). The preparation of antisera with specificity for catfish basic L-FABP (Di Pietro and SantomC, 1996) or rat L-FABP (Paulussen et al, 1990) has been reported previously.…”

Section: Methodsmentioning

confidence: 99%

Amino Acid Sequence, Binding Properties and Evolutionary Relationships of the Basic Liver Fatty‐Acid‐Binding Protein from the Catfish Rhamdia sapo

Pietro

Dell’Angelica

Veerkamp

et al. 1997

European Journal of Biochemistry

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The complete amino acid sequence of a basic liver fatty acid-binding protein (L-FABP) from catfish (Rhamdia s a p ) was determined. Alignment of sequences shows that it has more similarity to chicken basic L-FABP than to mammalian L-FABP. The phylogenetic analysis suggests that basic L-FABP from catfish, chicken and iguana diverged from the mammalian protein before the fish-tetrapod divergence, thus implying that the two types are encoded by different genes. Supporting this conclusion, a 14-kDa protein, structurally closely related to mammalian L-FABP, was isolated from catfish intestine, indicating the presence of the two genes in the same species. The catfish basic L-FABP binds only one fatty acid molecule, while mammalian L-FABP bind two. The former has more affinity for trans-parinaric acid than for cis-parinaric acid, in constrat to the latter proteins.

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“…H-FABP occurs in part in skeletal muscles as well, and its content in the myocardium is reportedly 3 to 10 times as high as in the skeletal muscle (1,2). H-FABP became recognized as a cardiac marker in the 1990s (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Relationship between Heart-Type Fatty Acid-Binding Protein Levels and the Risk of Death in Patients with Serious Condition on Arrival at the Emergency Department

et al. 2005

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Objective Although heart-type fatty acid-binding protein (H-FABP) is a cardiac marker useful for early diagnosis of acute myocardial infarction (AMI), few data are available on its prognostic value. The objective of this study is to clarify the prognostic value of H-FABP in patients with a serious condition. Methods and PatientsWe conducted a prospective study of 617 patients who presented to the emergency department with a serious condition. The H-FABP levels on arrival at the emergency department were divided into four groups using their quartiles. The endpoint was death from any causes in-hospital.Results H-FABP ranged from 1.2 to 2,300 ng/ml, with a median of 19.9 ng/ml, a 25%-value of 6.7 ng/ml and 75%-value of 54.0 ng/ml. The unadjusted rate of the mortality increased progressively with increasing H-FABP quartile point (11% for quartile-I, 22% for quartile-II, 36% for quartile-III, and 38% for quartile-IV; p<0.001). After adjustment for age, gender, systolic blood pressure and the presence or absence of cardiovascular disease, H-FABP was the independent factor to predict the mortality.Conclusion H-FABP has proven to be an independent factor for prognosis in patients with a serious condition on arrival at the emergency department. (Internal Medicine 44: 1039-1045, 2005)

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Immunochemical quantitation of fatty acid-binding proteins. Tissue distribution of liver and heart FABP types in human and porcine tissues

Cited by 68 publications

References 40 publications

Lipid Metabolism in Muscle

Lipid Metabolism in Muscle

Amino Acid Sequence, Binding Properties and Evolutionary Relationships of the Basic Liver Fatty‐Acid‐Binding Protein from the Catfish Rhamdia sapo

Relationship between Heart-Type Fatty Acid-Binding Protein Levels and the Risk of Death in Patients with Serious Condition on Arrival at the Emergency Department

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