Relationship between Heart-Type Fatty Acid-Binding Protein Levels and the Risk of Death in Patients with Serious Condition on Arrival at the Emergency Department

Abstract

Objective Although heart-type fatty acid-binding protein (H-FABP) is a cardiac marker useful for early diagnosis of acute myocardial infarction (AMI), few data are available on its prognostic value. The objective of this study is to clarify the prognostic value of H-FABP in patients with a serious condition. Methods and PatientsWe conducted a prospective study of 617 patients who presented to the emergency department with a serious condition. The H-FABP levels on arrival at the emergency department were divided into four groups using their quartiles. The endpoint was death from any causes in-hospital.Results H-FABP ranged from 1.2 to 2,300 ng/ml, with a median of 19.9 ng/ml, a 25%-value of 6.7 ng/ml and 75%-value of 54.0 ng/ml. The unadjusted rate of the mortality increased progressively with increasing H-FABP quartile point (11% for quartile-I, 22% for quartile-II, 36% for quartile-III, and 38% for quartile-IV; p<0.001). After adjustment for age, gender, systolic blood pressure and the presence or absence of cardiovascular disease, H-FABP was the independent factor to predict the mortality.Conclusion H-FABP has proven to be an independent factor for prognosis in patients with a serious condition on arrival at the emergency department. (Internal Medicine 44: 1039-1045, 2005)

Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine - a review

“…Indeed, Cardiac Troponin I (cTnI) strongly predicts mortality and/or length of hospital stay such as in the case of trauma [ 17 ], sepsis [ 18 ], pneumonia [ 19 ] and COVID-19, [ 20 ] although, cTnI should be considered more as a specific marker / “gold standard” for the diagnosis of AMI [ 21 ]. Likewise, other CBs such as Cardiac Troponin T (cTnT) [ 22 , 23 ], B-type natriuretic peptide (BNP) [ 24 ], N-terminal (NT)-pro hormone BNP (NT-proBNP) [ 25 , 26 ], soluble suppression of tumourigenicity 2 (sST2) [ 27 , 28 ] and Heart-type Fatty Acid-Binding Protein (H-FABP) [ 29 ], have all been shown to demonstrate some degree of prognostic value in critically ill subgroups. This could be extremely useful for daily practice on the ICU since early measurement of specific CBs may help clinicians to identify early risk of deterioration and may allow for optimisation of ICU resources.…”

Heart-type Fatty Acid-binding Protein Enables Rapid Risk Stratification In Patients With Pulmonary Embolism

“…Recently, it has been proposed that the de- Lately, several studies reported that heart-type fatty acid binding protein (H-FABP), a novel low molecular weight cytosolic protein, enables earlier and precise diagnosis and risk assessment in patients with acute coronary syndromes as compared to other biomarkers [7,8]. Recent data could even demonstrate an association of elevated levels of H-FABP with increased risk of death and major cardiac events in this setting, thus having important prognostic power [9].…”