Immunochemical characterization of parenchymal and reticuloendothelial cells of rat liver

Lundkvist, U.; Goeringer, G.C.; Perlmann, Peter

doi:10.1016/0014-4800(66)90024-4

Cited by 17 publications

(1 citation statement)

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“…The sensitive and precise methods of immunochemistry have recently been applied to this problem, and thus far have proven to be of considerable value in the molecular 'dissection' of this tissue. For example, the distribution of various proteins and en zymes within rat liver subfractions, and their presence in other tissues, have been analyzed [1][2][3][4][5][6][7][8][9]. It was found that subcellular fractions of liv er from this species revealed a total of 33 antigenic constituents not re-…”

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confidence: 99%

Analysis of the Tissue Constituents and Enzymes of Human Liver by Crossed Immunoelectrophoresis – Comparison of Normal and Cystic Fibrosis Liver

Greene¹,

Halbert²,

Jequier³

1972

Int Arch Allergy Immunol

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The tissue composition of human liver has been analyzed by a highly resolving new technic, crossed immunoelectrophoresis, using potent anti-liver serum absorbed with human plasma. As many as 57 different constituents which were unrelated to plasma proteins were revealed. Liver extracts from cystic fibrosis patients showed significantly fewer components than did the normal tissue. Of the liver constituents detected by this method, six were identified as distinct enzymes, including 3 esterases, 1 glucosaminidase, 1 glucuronidase and 1 catalase. No consistent alterations in these liver enzymes were found in cystic fibrosis livers. Kidney, submaxillary gland and pancreas shared, respectively, 45, 16 and 18 antigens with liver, as determined by their cross-reactivity with the anti-liver serum. A single tissue esterase revealed in kidney with this antiserum was clearly distinct from the single predominant esterase seen in lung with this reagent.

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confidence: 99%