Immunochemical and Biological Characteristics of a Human Autoantibody to Human Chorionic Gonadotropin and Luteinizing Hormone*

Pala, Andrea Norcini; Coghi, I; Spampinato, Giuseppe; Gregorio, Rosangela Di; Strom, Roberto; Carenza, L

doi:10.1210/jcem-67-6-1317

Cited by 14 publications

(4 citation statements)

References 10 publications

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“…Anti-FSH antibodies may be naturally occurring antibodies associated with peripheral FSH concentrations and produced in higher levels in infertile women (Haller et al ., 2007). Case reports have also been published on the presence of (transient) anti-hCG antibodies in infertile women with recurrent pregnancy loss (Pala et al , 1988; Amato et al ., 2002). …”

Section: Discussionmentioning

confidence: 99%

Repeated ovarian stimulation with corifollitropin alfa in patients in a GnRH antagonist protocol: no concern for immunogenicity

et al. 2011

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BACKGROUNDOne injection of corifollitropin alfa replaces the first seven daily FSH injections in controlled ovarian stimulation (COS) cycles. Repeated treatment with therapeutic proteins may cause immune responses or hypersensitivity reactions. We assessed the immunogenicity and safety of corifollitropin alfa treatment in up to three COS cycles.METHODSIn this multicentre, phase III uncontrolled trial, patients (>60 kg) started treatment with one injection of 150 µg corifollitropin alfa on cycle Day 2 or 3 of menses and 0.25 mg ganielix on stimulation Day 5 or 6. Primary outcome measures were antibody formation against corifollitropin alfa (using highly sensitive radioimmunoprecipitation assay), hypersensitivity reactions, local tolerance and adverse events (AEs).RESULTSFirst, second and third COS cycles were started by 682, 375 and 198 patients, respectively. No clinically relevant immunogenicity or drug-related hypersensitivity was observed. For 192 patients undergoing their third cycle a post-treatment blood sample was negative in the anti-corifollitropin antibody assay, resulting in an upper limit of the one-sided 95% confidence interval (CI) of 1.5%. Most frequent AEs were procedural pain (17.7%, 95% CI: 14.9–20.8%), headache (9.1%, 95% CI: 7.0–11.5%) and pelvic pain (7.6%, 95% CI: 5.7–9.9%).Cumulative ongoing pregnancy rate after three cycles, including frozen-thawed embryo transfer cycles and spontaneous pregnancies, was 61% (95% CI: 56–65%) after censoring for patients who discontinued.CONCLUSIONSTreatment with corifollitropin alfa can safely and effectively initiate and sustain ovarian stimulation during the first 7 days of COS in normal responder patients undergoing up to three treatment cycles, without concerns of immunogenicity.The trial was registered under ClinicalTrials.gov identifier NCT00696878.

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Section: Discussionmentioning

confidence: 99%

Repeated ovarian stimulation with corifollitropin alfa in patients in a GnRH antagonist protocol: no concern for immunogenicity

et al. 2011

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“…These antibodies were low affinity and did not interfere with hormone activity. However, few years later, antibodies with high affinity and the capacity to neutralize hCG and LH activities were detected in a patient with a history of spontaneous abortion, that was never exposed to exogenous hormone therapy (80).…”

Section: Antibodies Modulating the Activity Of Chorionic Gonadotropinsmentioning

confidence: 99%

Modulation of Gonadotropins Activity by Antibodies

Kara¹,

Dupuy²,

Bouillon

et al. 2019

Front. Endocrinol.

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Gonadotropins are essential for reproduction control in humans as well as in animals. They are widely used all over the world for ovarian stimulation in women, spermatogenesis stimulation in men, and ovulation induction and superovulation in animals. Despite the availability of many different preparations, all are made of the native hormones. Having different ligands with a wide activity range for a given receptor helps better understand its molecular and cellular signaling mechanisms as well as its physiological functions, and thus helps the development of more specific and adapted medicines. One way to control the gonadotropins' activity could be the use of modulating antibodies. Antibodies are powerful tools that were largely used to decipher gonadotropins' actions and they have shown their utility as therapeutics in several other indications such as cancer. In this review, we summarize the inhibitory and potentiating antibodies to gonadotropins, and their potential therapeutic applications.

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“…Unfortunately, that is not fully understood at present. However, immune complexes with numerous serum bioactive substances have been also reported in recent years [135,[196][197][198][199][200][201][202][203][204][205][206][207][208]. For example, blood coagulation factor, various hormones (triiodothyroxine, thyroxine, chorionic gonadotropin, pituitary hormones and so on), vitamin B12, myocardial markers and so on complexed with immunoglobulin.…”

Section: Othersmentioning

confidence: 99%

Laboratory and clinical features of abnormal macroenzymes found in human sera

Moriyama

Tamura

Nakano

et al. 2015

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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We report the analysis of unusual macroenzymes, performed in our laboratory, and review the relevant literature. In particular, we focused on macro AST, macroamylase, macro LD and macro CK. Macroenzymes are seen in healthy subjects, but can also be related to disease; thus, accurate detection is useful in day-to-day clinical practice. The macroenzyme is thought to be a specific antigen–antibody complex from the following findings: (1) the complex could be dissociated under acidic pH levels; (2) binding specificity of immunoglobulin in the complex was observed; (3) the binding site of immunoglobulin in the complex was Fab portion; and (4) the maternal IgG involved with macroenzyme was transferred to her children. This article is part of a Special Issue entitled: Medical Proteomics

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Immunochemical and Biological Characteristics of a Human Autoantibody to Human Chorionic Gonadotropin and Luteinizing Hormone*

Cited by 14 publications

References 10 publications

Repeated ovarian stimulation with corifollitropin alfa in patients in a GnRH antagonist protocol: no concern for immunogenicity

Repeated ovarian stimulation with corifollitropin alfa in patients in a GnRH antagonist protocol: no concern for immunogenicity

Modulation of Gonadotropins Activity by Antibodies

Laboratory and clinical features of abnormal macroenzymes found in human sera

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