Immunoblastic lymphoma and associated non‐lymphoid malignancies following two cases of Waldenström's macroglobulinemia. A review of the literature

García, Rafael Martínez; Hernández, Jesús M.; Caballero, M D; González, M.P.; Miguel, J.F. San

doi:10.1111/j.1600-0609.1993.tb00167.x

Cited by 18 publications

(2 citation statements)

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“…In 1996, Carter et al 26 reported a case of IVBCL developing in a patient with nodal follicular lymphoma. 28 There is limited literature precedent on IVL TCL. However, the follicular lymphoma was not identified in the initial bone marrow biopsy despite a retrospective review of the cervical LN biopsy slides obtained 3 years before and showed diagnostic features of a follicular small cleaved cell lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Unusual Variants of Intravascular Malignant Hematopoietic Neoplasms

Nguyen

Yassin

Magro

2015

The American Journal of Dermatopathology

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Intravascular lymphoma (IVL) is a rare and fatal disease, typically of B-cell origin. Most of the reported cases have been for primary IVL, and only a minority of cases are of recurrent IVL. In addition, recurrent IVL occurring after treatment of anaplastic large T-cell lymphoma (ALCL) by contrast is extraordinarily rare. In this article, we present 3 cases of recurrent cutaneous IVL (2 men and 1 woman) and compare these with 1 case of primary IVL. The patients ranged in age from 56 to 73 years and were encountered in the routine dermatopathology and consultative practices of one of the authors. In 2 of the cases, the patients had intravascular cutaneous ALCL. In regard to the remaining 2 patients, 1 patient had a recurrent intravascular cutaneous follicular lymphoma in the context of a history of diffuse large B-cell lymphoma. The fourth patient had a primary intravascular ALCL because there was no antecedent history. In all cases, the skin biopsies showed large aggregates of atypical cells within the blood vessels. Phenotypic studies revealed variable staining results with CD29 and CD54 in cases of recurrent IVL compared with those of primary IVL. Recurrent cutaneous IVL represents a somewhat heterogeneous group of lymphoproliferative disorders with a distinct variant being in the context of intravascular ALCL; the mechanisms of intravascular localization in recurrent IVL are likely different from those of primary IVL.

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Section: Discussionmentioning

confidence: 99%

Unusual Variants of Intravascular Malignant Hematopoietic Neoplasms

Nguyen

Yassin

Magro

2015

The American Journal of Dermatopathology

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“…Ови на ла зи указу ју на за сту пље ност два раз ли чи та лим фом ска клона, а не на тран сфор ма ци ју ВМ у агре сив ни ју бо лест. Раз вој ВМ и хро нич них об ли ка лим фо ма у ДКНХБЛ се од ли ку је агре сив ним кли нич ким то ком, ло шом прогно зом и крат ким пре жи вља ва њем бо ле сни ка и по ред при ме не ин тен зив не те ра пи је [8]. Код при ка за ног боле сни ка, ко ји је ле чен иму но хе ми о те ра пи јом, по стигнут је од ли чан од го вор, тј.…”

Section: дискусијаunclassified

Diffuse large cell lymphoma and colon adenocarcinoma in patient with Waldenström’s macroglobulinaemia

et al. 2011

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Waldenstrom's macroglobulinemia transformed into immunoblastic lymphoma presenting with malignant ascites

1996

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Letters and Correspondence 249gous to Richter's syndrome occurring with chronic lymphocytic leukemia [ 11. Transformation is signaled by diffuse lymphadenopathy, fevers, night sweats, and weight loss [2]. To our knowledge, we report the first case of a patient with malignant ascites as a presenting manifestation of WM that transformed into L.A 57-year-old male with a history of WM presented with 2 weeks of progressive abdominal distention, cervical adenopathy, fevers, night sweats, and weight loss. Ten years previously, he was diagnosed with WM. Immunocytochemistry of a marrow specimen demonstrated the majority of cells to be IgM kappa-positive. He received multiple agents, including cyclophosphamide, vincristine, prednisone, and chlorambucil. He had no history of ethanol use or liver disease.Physical examination revealed left-sided cervical, supraclavicular. and axillary adenopathy. The abdomen was distended with shifting dullness. Serum lactate dehydrogenase (LDH) was 1,s 17 uniM and plasma viscosity was 2.87 (nl 0.99-1.55). White blood cell count was 24,000 cells/mm' with 30% immunoblasts, suggesting transformation of WM into a more aggressive neoplasm. Flow cytometry of these cells was consistent with WM. Paracentesis revealed numerous cells similar in morphology to the immunoblasts in the peripheral blood (Fig. 1); the culture was sterile. Ultrasound of the liver was normal. Computerized tomography scan showed massive thoracic and abdominal lymphadenopathy. A cervical lymph node biopsy was consistent with 1L and stained positive for IgM kappa, supporting clonal transformation. The patient denied further intervention and died 13 days after admission.Transformation of WM into IL is a rare event, occurring in approximately 1.7% of cases of WM [3]. The mean survival once transformation occurs in 2 months [2]. hior therapy with alkylating agents may predispose to transformation. though this remains to be proven [3]. IL is characterized by the monomorphous proliferation of immunoblasts. which are large cells with plasmacytoid features [I]. Both WM and IL are clonal diseases, and the change in histologic appearance of the cells characteristic of WM into the larger cells of IL is believed to represent evolution of the same clone of cells. Furthermore, the appearance of identical heavy and light chains on both tumor cell types supports clonal evolution [4].Ascites due to IL is very rare. Peritoneal lymphomatosis is much less common than peritoneal carcinomatosis and carries a dismal prognosis [5]. Runyon and Hoefs [5] reported on three patients with malignant ascites as could be obtained by shortening the duration of OC administration. No interferences with hemostatic balance are documented.

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Immunoblastic lymphoma and associated non‐lymphoid malignancies following two cases of Waldenström's macroglobulinemia. A review of the literature

Cited by 18 publications

References 13 publications

Unusual Variants of Intravascular Malignant Hematopoietic Neoplasms

Unusual Variants of Intravascular Malignant Hematopoietic Neoplasms

Diffuse large cell lymphoma and colon adenocarcinoma in patient with Waldenström’s macroglobulinaemia

Waldenstrom's macroglobulinemia transformed into immunoblastic lymphoma presenting with malignant ascites

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