Immunoaffinity Knockout of Saponin Glycosides from <i>Asparagus racemosus</i> to Assess Anti‐lipid Peroxidation

Onlom, Churanya; Phrompittayarat, Watoo; Putalun, Waraporn; Waranuch, Neti; Ingkaninan, Kornkanok

doi:10.1002/pca.2678

Cited by 10 publications

(6 citation statements)

References 24 publications

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“…In addition, MDA level was determined as an end product of lipid peroxidation and also reliable marker of oxidative stress (Onlom et al, 2017). Our results clearly demonstrated that, the ginger and turmeric root powder counteracted acetone induced oxidative stress and ameliorated its effects on antioxidant enzyme activities.…”

Section: Discussionmentioning

confidence: 51%

Attenuation of Acetone Induced Liver and Kidney Injury by Ginger and Turmeric Root Powder in Chickens

El‐Rahman

Elwan

El-Shafei

et al. 2018

AJAS

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Ginger and turmeric are commonly used in food as spices with wellreported antioxidant activity. However, hepatoprotective and nephroprotective effects of ginger and turmeric have not been adequately studied. Therefore, the current study used chicken model with acetone induced liver and kidney injuries to evaluate the hepatoprotective and nephroprotective activities of ginger and turmeric because metabolic functions of chicken and human liver is similar. Eighty cocks were randomized into 5 experimental groups of chicks. The first one served as control. While the second group was received 350mg acetone/kg body weight (given in drinking water) per day for 30 days. The third, fourth and fifth groups were received ginger, turmeric and mix of ginger and turmeric by 1% in food respectively after treatment with acetone. Hematological parameters, liver and renal function tests, hepatic oxidative stress enzymes, as well as, histopathological examination scores were determined. Results indicated that, administration of acetone induces alteration in various hematological parameters, hepatic enzymes and hepatic oxidative stress enzymes in chickens. Dietary supplementation of ginger (GEN) and turmeric (TUR) caused a significant amelioration in some hematological parameters in acetone treated chickens. GEN and TUR treatments could reduce damage induced by acetone in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGT), glucose, total protein and their fractions levels. Furthermore, acetone promoted a significant increase in urea, uric acid and creatinine levels, while treatment with GEN or TUR or GEN+TUR at the same time of treatment with acetone maintained urea and uric acid concentrations at a level similar to the control group. Interestingly, GEN, TUR and GEN+ TUR treatments significantly ameliorated effects of acetone on chickens by improving the levels of the main antioxidant enzymes (superoxide dismutase SOD, glutathione-S-transferase GST) and malondialdehyde (MDA) a reliable marker of lipid peroxidation in the cells. Histologically, acetone appeared to be hepatotoxic in chick's. Hepatocytes were sensitive to the treatment with acetone and contained large number of congested blood vesicles, cytoplasmic vacuoles, pyknotic nuclei, and lymphocytic infiltration in treated animals. Turmeric and ginger treatments improved the vast majority of hepatic changes. Our findings broadly confirmed that, the supplementation of ginger and turmeric significantly alleviated liver and kidney functions, hema-

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Section: Discussionmentioning

confidence: 51%

Attenuation of Acetone Induced Liver and Kidney Injury by Ginger and Turmeric Root Powder in Chickens

El‐Rahman

Elwan

El-Shafei

et al. 2018

AJAS

View full text Add to dashboard Cite

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“…Lipid peroxidation, a reliable marker of oxidative stress, is a well-defined mechanism of cellular damage in different pathological conditions. MDA is the end product of lipid peroxidation, which is implicated in the promotion and progression stages of carcinogenesis (Onlom et al, 2017[ 26 ]). As presented in Figure 4 (Fig.…”

Section: Discussionmentioning

confidence: 99%

Cancer chemoprevention by oleaster (Elaeagnus angustifoli L.) fruit extract in a model of hepatocellular carcinoma induced by diethylnitrosamine in rats

Amereh

Hatami

Shirazi

et al. 2017

EXCLI Journal; 16:Doc1046; ISSN 1611-2156

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“…Li et al ( 57 ) found that the total saponin content in A. officinalis roots was 3.6 times higher than that in A. officinalis spears. Moreover, Shatavarin saponin glycosides from ARs have shown moderate protection against Cu + -induced oxidation of human low-density lipoprotein (LDL) with no inhibition of lipid peroxidation as determined by thiobarbituric acid reactive assay (TBARs) ( 58 ). Isoflavones, asparagamine, racemosol, polysaccharides, and mucilage were also reported by Chawla et al ( 59 ).…”

Section: Bioactive Compounds In Asparagusmentioning

confidence: 99%

Literature analysis on asparagus roots and review of its functional characterizations

et al. 2023

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Asparagus root (AR) is utilized globally as a traditional herbal medicine because it contains various bioactive compounds, such as polyphenols, flavonoids, saponins, and minerals. The composition profiles of AR are strongly affected by its botanical and geographical origins. Although minerals and heavy metals are minor constituents of AR, they play a crucial role in determining its quality and efficacy. A comprehensive classification of AR, its phytochemistry, and its pharmacology were reviewed and interpreted herein. Potentially eligible articles (in English) were identified through an electronic search of the Web of Science database (2010–2022) and Google (2001–2022). We used the primary search term “Asparagus roots” combined with the words “pharmacology,” “bioactive compounds,” “physicochemical properties,” and “health benefits” to find the relevant literature. We screened the titles, keywords, and abstracts of the publications obtained from the database. A full copy of the article was obtained for further assessment if deemed appropriate. Different asparagus species might potentially be used as herbal medicines and functional foods. Phytochemical studies have revealed the presence of various bioactive compounds as valuable secondary metabolites. The dominant class of bioactive compounds in AR is flavonoids. Furthermore, AR displayed significant pharmacological effects, such as antioxidant, antimicrobial, antiviral, anticancer, anti-inflammatory, and antidiabetic effects, as shown in animal and human studies. This review provides a valuable resource to enable a thorough assessment of the profile of Asparagus root as a functional ingredient for the pharmaceutical and food industries. In addition, it is anticipated that this review will provide information to healthcare professionals seeking alternative sources of critical bioactive compounds.

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Immunoaffinity Knockout of Saponin Glycosides from Asparagus racemosus to Assess Anti‐lipid Peroxidation

Cited by 10 publications

References 24 publications

Attenuation of Acetone Induced Liver and Kidney Injury by Ginger and Turmeric Root Powder in Chickens

Attenuation of Acetone Induced Liver and Kidney Injury by Ginger and Turmeric Root Powder in Chickens

Cancer chemoprevention by oleaster (Elaeagnus angustifoli L.) fruit extract in a model of hepatocellular carcinoma induced by diethylnitrosamine in rats

Literature analysis on asparagus roots and review of its functional characterizations

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