Immuno-stimulating Activities of Skipjack Tuna Katsuwonus pelamis Cooking Juice Concentrates on Mouse Macrophages and Spleen Cells

Kang, Bo‐Kyeong; Kim, Koth-Bong-Woo-Ri; Ahn, Na-Kyung; Choi, Yeon-Uk; Kim, Minji; Bark, Si-Woo; Pak, Won-Min; Kim, Boram; Park, Ji-Hye; Bae, Nan-Young; Ahn, Dong-Hyun

doi:10.5657/kfas.2014.0776

Cited by 5 publications

(3 citation statements)

References 46 publications

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“…The spleen is responsible for the key protective immune response against antigens and is known to be the main lymphoid organ where B and T lymphocytes differentiate. Thus, the growth of the spleen cells is considered to be of utmost significance in the immune system [ 44 ]. The thymus is one of the central lymphoid organs and has been shown to play an important role in cellular immunity by producing mature T lymphocytes from immature T lymphocytes [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Enhancement of Immune Activities of Mixtures with Sasa quelpaertensis Nakai and Ficus erecta var. sieboldii

Kwon

Choi

Han

et al. 2020

Foods

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The objective of the present study was to develop a concoction of natural products that could dramatically improve immune function with minimal possible side effects. Sasa quelpaertensis Nakai and Ficus erecta var. sieboldii are plants that are native to Jeju Island, Korea and are known to be rich in physiologically active substances. We prepared a mixture of different proportions and extraction conditions using two natural plants and determined their optimum mixing ratio and extraction method by assessing immune function-related biomarkers in RAW264.7 macrophages. Optimal extract (HR02/04(8:2)-W) was selected from in vitro experiments and its immunity-enhancing efficacy was evaluated in mice. After oral administration of extract to BALB/c mice for 2 weeks, nitric oxide production in the peritoneal exudate cells, natural killer cell cytotoxicity, cytokine expression in splenocytes, and total cell number of immune tissues and phenotype analysis were evaluated. Our results demonstrated that HR02/04(8:2)-W significantly enhanced the immune system by increasing natural killer cell activity, cytokine expression, and total number of cells in immune tissues. In conclusion, our study validates the role of HR02/04(8:2)-W in enhancing immunity and its potential development as a functional food.

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Section: Resultsmentioning

confidence: 99%

Enhancement of Immune Activities of Mixtures with Sasa quelpaertensis Nakai and Ficus erecta var. sieboldii

Kwon

Choi

Han

et al. 2020

Foods

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“…In our previous study, desalinated TCD was found to be a potential immunomodulator [11] and increased cytokine production by RAW 264.7 cells and splenic cells in vitro. Therefore, we conducted animal experiments to evaluate the immune-enhancement effects of TCD and EH-TCD intraperitoneally administered to Balb/c, and to determine their effects on serum immunoglobulin levels and cytokine production from spleen cells.…”

Section: Introductionmentioning

confidence: 86%

Immune-enhancement effects of tuna cooking drip and its enzymatic hydrolysate in Balb/c mice

Kim

Sung

et al. 2017

Food Sci Biotechnol

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Tuna cooking drip (TCD) is a protein rich by-product of canned tuna processing that is typically discarded. In this study, the immune-enhancing activities of TCD and its enzymatic hydrolysate (EH-TCD) were investigated by intraperitoneally administering Balb/c male mice with TCD and EH-TCD for 2 weeks. This administration resulted in an increase in the weight of the spleen and thymus (200-800 mg/kg) and enhanced the proliferation rates of splenocytes (200-800 mg/kg). TCD and EH-TCD significantly increased the production of immunostimulatory cytokines (interleukin-10 and interleukin-2). In addition, TCD and EH-TCD increased serum IgG1 and IgG2a levels in a concentration-dependent manner. Particularly, EH-TCD had a greater immune-enhancing effect than TCD. These results suggest that TCD and EH-TCD exert immune-enhancing effects through an IgG antibody response and T cell activation, and EH-TCD can be used as an immunostimulatory agent.

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“…Th1 cells and Th2 cells regulate the immune response by balancing each other. Kang et al [41] reported that cytokine productions by both Th1 and Th2 were increased by tuna cooking juice concentrate. Similarly, our study showed that the production of INF-γ, TNF-α, IL-4, and IL-10 increased in splenocytes and T cells isolated from mice treated for 10 days with 1 mg/kg BW LcV.…”

Section: Cytokines Production In Cona-stimulated Splenocytes Isolated From Mouse Treated For 10 Days With Lcvmentioning

confidence: 99%

Immunomodulatory Activity of Extracellular Vesicles of Kimchi-Derived Lactic Acid Bacteria (Leuconostoc mesenteroides, Latilactobacillus curvatus, and Lactiplantibacillus plantarum)

Kim

Lee

Kim

et al. 2022

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Lactic acid bacteria present in Kimchi, such as Leuconostoc mesenteroides (Lm), Latilactobacillus curvatus (Lc), and Lactiplantibacillus plantarum (Lp) produce extracellular vesicles (ECVs) that modulate immune responses. The ECVs of probiotic Kimchi bacteria are abbreviated as LmV, LcV, and LpV. Treatment of macrophages (RAW264.7) with ECVs (LmV, LcV, and LpV) increased the production of nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin-6 (IL-6). Immunostimulatory effects exerted on the RAW264.7 cells were stronger after treatments with LmV and LcV than with LpV. Treatment of mice with LcV (1 mg/kg, orally) induced splenocyte proliferation and subsequent production of both NO and cytokines (INF-γ, TNF-α, IL-4, and IL-10). Furthermore, pre-treatment of macrophages and microglial cells with ECVs prior to LPS stimulation significantly attenuated the production of NO and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6). Therefore, ECVs (LmV, LcV, and LpV) prevent inflammatory responses in the LPS-stimulated microglial cells by blocking the extracellular signal-regulated kinase (Erk) and p38 signaling pathways. These results showed that LmV, LcV, and LpV from Kimchi probiotic bacteria safely exert immunomodulatory effects.

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Immuno-stimulating Activities of Skipjack Tuna Katsuwonus pelamis Cooking Juice Concentrates on Mouse Macrophages and Spleen Cells

Cited by 5 publications

References 46 publications

Enhancement of Immune Activities of Mixtures with Sasa quelpaertensis Nakai and Ficus erecta var. sieboldii

Enhancement of Immune Activities of Mixtures with Sasa quelpaertensis Nakai and Ficus erecta var. sieboldii

Immune-enhancement effects of tuna cooking drip and its enzymatic hydrolysate in Balb/c mice

Immunomodulatory Activity of Extracellular Vesicles of Kimchi-Derived Lactic Acid Bacteria (Leuconostoc mesenteroides, Latilactobacillus curvatus, and Lactiplantibacillus plantarum)

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