Immuno-globulines anti-D Efficacité comparée des voies intra-musculaire et intra-veineuse

A New Preparation of Modified Immune Serum Globulin (Human) Suitable for Intravenous Administration

“…Such distri bution may have important therapeutic im plications [27]. Similar recovery data for IM and IV administration of ISG in humans have been reported [28,29],…”

Failure of Anti-D Immunoglobulin to Remove Fetal Red Cells from Maternal Circulation

“…The clinical significance of this is uncertain at the moment until further cases are eval Thus, the propositus gave reactions con sistent with a variant of the 'D' antigen. Fetal cells possessing the complete 'D' an tigen are usually removed from the maternal circulation within 48 h post-injection of an ti-D immunoglobulin [4], In the case de scribed here, the fetal cells possessed a vari ant of the 'D' antigen and after a total dose corresponding approximately to 50 jug anti-D/ml fetal red cells the cells had still not been cleared from the maternal circulation after 96 h. It is clear that the immunoglob ulin was potent, but failed to react with the modified 'D' antigen on the fetal cells when diluted by the maternal plasma volume, despite its presence being detected by stan dard control cells. The antigenicity of the uated to ascertain if maternal antibody for mation is likely to be stimulated.…”

Failure of Anti‐D Immunoglobulin to Remove Fetal Red Cells from Maternal Circulation

“…Thus, the propos,,us gave reactions consistent with a variant of the 'D' antigen. Fetal cells possessing the complete 'D' antigen are usually removed from the maternal circulation within 48 h post-injection of anti-D immunoglobulin [4]. In the case described here, the fetal cells possessed a variant of the 'D' antigen and after a total dose corresponding approximately to 50 pg anti-D/ml fetal red cells the cells had still not been cleared from the maternal circulation after 96 h. It is clear that the immunoglobulin was potent, but failed to react with the modified 'D' antigen on the fetal cells when diluted by the maternal plasma volume, despite its presence being detected by standard control cells.…”