A Rhesus negative female was found post delivery to have circulating cells of
fetal origin. The neonate was typed as D-positive. In spite of more than conventionally adequate
doses of anti-D immunoglobulin given to the mother, the fetal cell count in the maternal
circulation remained unchanged. Further investigation showed the fetus to be a Du variant
and to exhibit a diminished reaction with the batch of anti-D immunoglobulin used.
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