Immunization of BALB/c mice with DNA encoding equine herpesvirus 1 (EHV-1) glycoprotein D affords partial protection in a model of EHV-1-induced abortion

Walker, Clinton; Ruitenberg, K. M.; Love, Daria N.; Whalley, J. M.

doi:10.1016/s0378-1135(00)00262-5

Cited by 14 publications

(4 citation statements)

References 21 publications

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“…More recently, the potential of DNA-mediated immunisation, baculovirus-expressed proteins or a combination was demonstrated in a murine model of respiratory infection and abortion (114,127,128,129,180). Inoculation of gD DNA also stimulated gD specific and VN responses in horses (128).…”

Section: Protection Against Abortionmentioning

confidence: 99%

Equine herpesvirus 1 and 4 infections: An update

Maanen

2002

Veterinary Quarterly

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Summary Equine herpesvirus 1 (EHV1) and equine herpesvirus 4 (EHV4) are important ubiquitous equine pathogens, causing much damage to the viral horse industry. EHV1 strains are associated with respiratory disease, abortion, and paresis/paralysis, whereas EHV4 strains are predominantly associated with respiratory disease. In the past decades much research effort has been put into improving knowledge about these viruses. In this paper the current state of knowledge of these viruses and the most important aspects of these virus infections, e.g. epidemiology, clinical aspects, pathogenesis and pathology, immunity, diagnosis, preventive management and management in the course of an outbreak and vaccination, is reviewed. Because we performed some research ourselves in the areas of diagnosis, epidemiology and vaccinology these aspects are reviewed in more depth than the other aspects. Still many questions have remained and new questions have risen. Consequently, research priorities should be made in an attempt to answer these questions. Therefore, this review ends with some personal recommendations for important priorities for future research.

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Section: Protection Against Abortionmentioning

confidence: 99%

Equine herpesvirus 1 and 4 infections: An update

Maanen

2002

Veterinary Quarterly

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“…These studies have involved different vaccination strategies and they mainly used non-purified glycoproteins and parenteral routes of immunization. Most of the vaccines have been evaluated using the murine respiratory model of the disease (Awan et al, 1991(Awan et al, , 1995Iwai et al, 1998;Walker et al, 1999), but for the abortion model only DNA encoding glycoprotein D (gD) of was used (Walker et al, 2000). Glycoprotein D is a component of the viral envelope involved in viral entry into host cells (Whittaker et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Intranasal Immunization with Recombinant Glycoprotein D in Pregnant BALB/c Mice Challenged with Different Strains of Equine Herpesvirus 1

Fuentealba

Zanuzzi

Scrochi

et al. 2014

Journal of Comparative Pathology

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“…Within the last decade, several studies in mice have evaluated the antigenicity and efficacy of DNA vaccination against EHV-1 infection. A DNA vaccine encoding gD has been shown to elicit both humoral and cell-mediated immune responses after two intramuscular immunisations, and to reduce respiratory lesions, the amount and duration of virus shedding [135,136], and abortion [137] induced by challenge infection. The protection was improved by modifying the scheme of vaccination and including a protein booster immunisation with gD, 4 weeks after a DNA priming [138].…”

Section: Dna Vaccines Against Ehv-1mentioning

confidence: 99%

Equine Herpes Virus-1: Virus, Immunity and Vaccines

Paillot¹,

Case²,

Ross³

et al. 2008

TOVSJ

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Equine Herpes virus-1 (EHV-1) is one of the most common respiratory pathogens of the horse. EHV-1 induces several clinical signs of disease ranging in severity, from mild respiratory distress to abortion in pregnant mares, neonatal foal death and neuropathogenic disorders. This review details some aspects of EHV-1 biology, its life cycle and pathogenicity in the natural host. Protective immunity stimulated by natural EHV-1 infection, which is short lived and depends of both humoral and cellular immune responses, will also be treated here. Vaccination remains today one of the best options to fight EHV-1 infection and several different strategies of vaccination that have been investigated and developed over the past decades will be presented in this report. EHV-1 Eq. abortion virus α2 Respiratory, abortion, neurological EHV-2 Eq. cytomegalovirus γ3 NA EHV-3 Eq. coital exanthema virus α Coital exanthema EHV-4 Eq. rhinopneumonitis virus α2 Respiratory Equus caballus EHV-5 Eq. cytomegalovirus γ3 NA AHV-1/EHV-6 Related to EHV-3 α Coital exanthema AHV-2/EHV-7 Related to EHV-2 γ3 NA Equus asinus AHV-3/EHV-8 Related to EHV-1 α Rhinitis Gazella thomsoni GHV-1/EHV-9 Similar to EHV-1/EHV-8 α Ga.&Eq. neurological Eq. = equine; Ga. = gazelle; NA= not associated.

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Immunization of BALB/c mice with DNA encoding equine herpesvirus 1 (EHV-1) glycoprotein D affords partial protection in a model of EHV-1-induced abortion

Cited by 14 publications

References 21 publications

Equine herpesvirus 1 and 4 infections: An update

Equine herpesvirus 1 and 4 infections: An update

Protective Effects of Intranasal Immunization with Recombinant Glycoprotein D in Pregnant BALB/c Mice Challenged with Different Strains of Equine Herpesvirus 1

Equine Herpes Virus-1: Virus, Immunity and Vaccines

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