IMMUNIZATION IN THE YOUNG INFANT&lt;subtitle&gt;Response to Combined Vaccines: VI-X&lt;/subtitle&gt;

Peterson, John C.

doi:10.1001/archpedi.1951.02040030529005

Cited by 20 publications

(2 citation statements)

References 29 publications

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“…There have been conflicting reports as to whether or not passive transport of maternal tetanus or diphtheria antibody interferes with the infants' response to immunization with the respective antigen (23)(24)(25)(26). We found no correlation between maternal or newborn preterm infant tetanus and diphtheria IgG antibody levels, and the antibody levels to these antigens at 9 months of age.…”

Section: Discussioncontrasting

confidence: 72%

Longitudinal Development of Specific and Functional Antibody in Very Low Birth Weight Premature Infants

Goetz

Rosenberg

et al. 1988

Pediatr Res

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ABSTRACT. We evaluated the formation of specific and functional antibody in preterm infants born weighing less than 1500 g (mean 1088 g) and less than 32 wk gestational age (mean 28.8 wk). Plasma IgG antibody against tetanus and diphtheria toxoids were measured by an enzyme-linked immunosorbent assay. Opsonic activity of heat-inactivated plasma was measured using radiolabeled bacteria, adult polymorphonuclear leukocytes and exogenous human complement. In the presence of complement, the strain of coagulase negative staphylococcus used was opsonized by IgG antibody, and the strain of Escherichia coli by IgM. Geometric mean plasma levels of tetanus and diphtheria IgG antibody fell from birth to 4 months chronological age, but rose significantly by 9 months (approximately 2 months after the third dose of diphtheria, tetanus, pertussis vaccine). However, at 9 months they remained lower than the respective geometric mean levels in 9-month-old term infants (tetanus: p < 0.001; diphtheria: p = 0.02). The preterm infants' mean glasma IgG staphylococcal opsonic activity fell from birth to 2.5 months, but by 9 months was comparable to that of term infants of the same age. Mean IgM opsonic activity for E. coli was very low at birth in both preterm and term infants. It rose with chronological age, correlating with the rise in total IgM (r = 0.48, p < 0.001) and by 9 months the mean preterm and term infants' levels of IgM opsonic activity for E. coli were comparable. In the newborn period, the preterm infants' levels of plasma IgG tetanus and diphtheria antibody, but not IgG staphylococcal opsonic activity, correlated with their mothers' levels (tetanus: r = 0.84, p < 0.001; diphtheria: r = 0.86, p < 0.001; staphylococcal: r = 0.17, p = 0.38). Placentally

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Section: Discussioncontrasting

confidence: 72%

Longitudinal Development of Specific and Functional Antibody in Very Low Birth Weight Premature Infants

Goetz

Rosenberg

et al. 1988

Pediatr Res

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“…In contrast to rigorous responses to locally acting antigens, parenteral immunisation of young infants and young primates has resulted in low or even absent antibody responses. For example, pertussis vaccine often fails to immunise infants during the first 3 months of life [9]. Injection of BSA into newborn Rhesus monkeys resulted in tolerance [11].…”

Section: Discussionmentioning

confidence: 99%

Decreased production of specific antibodies to cow's milk proteins in premature infants during the first six months of life

Helms

Rieger

1987

Eur J Pediatr

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Current Immunization Methods and Materials

Menzin¹

1961

Arch Intern Med

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IMMUNIZATION IN THE YOUNG INFANT<subtitle>Response to Combined Vaccines: VI-X</subtitle>

Cited by 20 publications

References 29 publications

Longitudinal Development of Specific and Functional Antibody in Very Low Birth Weight Premature Infants

Longitudinal Development of Specific and Functional Antibody in Very Low Birth Weight Premature Infants

Decreased production of specific antibodies to cow's milk proteins in premature infants during the first six months of life

Current Immunization Methods and Materials

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