Immunity toTrichinella spiralisIII. The longevity of the intestinal phase of the infection in mice

Abstract

It was found that with high level infections of Trichinella spiralis self-cure in immune mice occurs only slightly earlier than in normal mice. With low level infections self-cure is much earlier. In the host parasite combination studied the majority of the adult worms were found in the posterior part of the small intestine and no migration along the intestine was found. It is postulated that as migration is of such a variable occurrence it is not a necessary accompaniment to self-cure in T. spiralis infections. Where an early self-cure occurs it is obviously an important component of the immunity complex but other components such as reduced fecundity are equally important in limiting larval invasion of the muscles of immune mice.

Strongyloides ratti: 1. Parasitological observations on primary and secondary infections in the small intestine of rats

“…Most nematode infections of the intestine of rodents are expelled earlier from animals which have had a previous infection than they are from animals given only a primary infection. This occurs with Nippostrongylus brasiliensis in rats (Ogilvie, 1969), Trichinella spiralis in mice, rats and guinea-pigs (McCoy, 1931;Roth, 1939;Culberston, 1942;Larsh et al, 1952;Denham, 1968;Wakelin and Lloyd, 1976), Trichuris muris infection in mice (Wakelin, 1967), Trichostrongylus colubriformis in guinea pigs (Herlich et al, 1956;Herlich, 1963;Rothwell and Dineen, 1973) and Strongyloides ratti in rats (Sheldon, 1937a, b).…”

Immunological regulation of Angiostrongylus cantonensis infections in rats: modulation of population density and enhanced parasite growth following one or two superimposed infections

“…It is also possible that larvae from the challenge dose migrated to and developed in ectopic sites, such as the spinal cord (MACKERRAS & SANDARS, 1955;JINDRAK, 1968;BHAIBULAYA, 1975) and the orbit of the eye especially in the optic nerve (SHOHO, 1966) and failed to reach maturity in the lungs; these tissues were not examined in this study. The immune response is known to influence other parasites to seek alternative sites of habitation (BRAMBELL, 1965;DOBSON, 1966;DUNSMORE, 1966;CONNAN, 1966CONNAN, , 1974DENHAM, 1968;ALPHEY, 1970).…”

Immunization of ferrets against Diroflaria immitis by means of chemically abbreviated infections

“…Anthelmintic drugs may have different effects on various life cycle stages of helminths, and these effects can be exploited in studying the immunogenicity of such stages. For example, various drugs can be used to interdict the normal development of Ancylostoma caninum, Trichinella spiralis, Haemonchus contortus, Ascaris mum and Schistosoma mansoni; and in each instance, the protective effect of the partial infection can be shown (Otto 1948, Campbell, Hartman & Cuckler 1963, Campbell & Timinski 1965, Christie, Brambell & Charleston 1964Denham 1966;Campbell 1963). This approach seems to have had only limited application in filarial infections.…”