<i>Strongyloides ratti</i>: 1. Parasitological observations on primary and secondary infections in the small intestine of rats

Moqbel, Redwan; Denham, D. A.

doi:10.1017/s0022149x0000763x

Cited by 35 publications

(19 citation statements)

References 17 publications

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“…The data are summarized in Figure 1. The course of infection in this strain is basically similar to that described in the inbred WAG and outbred Wistar and CFHB strains (Moqbel & Denham 1977, Moqbel & Wakelin 1979, in that worm loss commenced between days 16 and 20 with corresponding reductions in worm size and fecundity and a shift of population in to the posterior small intestine.…”

Section: Transfer Of Immunity With Imlnc Taken At Different Times Dursupporting

confidence: 73%

“…Details of the parasite, the methods used for infecting rats, for recovering and counting adult worms and for determining their size and fecundity have been described earlier (Moqbel & Denham 1977, Moqbel & Wakelin 1979. Values for worm lengths (in mm) and fecundities (expressed as number of eggs in utero per female worm) were based on examination of 1G30 randomly selected, glutaraldehyde-fixed worms from each group.…”

Section: The Parasitementioning

confidence: 99%

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Immunity to Strongyloides ratti in rats. 1. Adoptive transfer with mesenteric lymph node cells

Moqbel

Wakelin

1981

Parasite Immunology

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Adoptive transfer of immunity against the enteral phase of Strongyloides ratti was monitored using four parameters; namely, number of worms recovered, position occupied in the host's small intestine, worm length and fecundity. When immune mesenteric lymph node cells (IMLNC) were transferred from donors infected for 20, 26 or 32 days into recipients infected for 3 days, a marked acceleration of worm expulsion was evident by day 16 post-infection (p.i.). IMLNC from day-16 p.i. donors did not transfer expulsion. In an experiment in which recipients were given 2 x 10(8) or 1 x 10(8) IMLNC from donors infected for 26 days, accelerated worm expulsion occurred only with the higher inoculum, although manifestations of direct worm immunity, i.e. altered position and reduced length and fecundity, were evident in both cases. Transfer of IMLNC appeared to have no effect upon worm establishment; when cells were transferred on the day of infection a period of 16 days was necessary to effect both direct anti-worm immunity and expulsion, although the former was evident on day 14 p.i. However, when IMLNC were transferred to rats already infected for 6 days, a very significant reduction of their worm burden was apparent 10 days after IMLNC transfer.

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Section: Transfer Of Immunity With Imlnc Taken At Different Times Dursupporting

confidence: 73%

Section: The Parasitementioning

confidence: 99%

Immunity to Strongyloides ratti in rats. 1. Adoptive transfer with mesenteric lymph node cells

Moqbel

Wakelin

1981

Parasite Immunology

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“…Several investigators have shown that ELISA (5,28), indirect immunofluorescence tests (17), and the histamine release assay (10) with Strongyloides ratti larval antigens are essentially as sensitive as those using S. stercoralis for the detection of parasite-specific IgG and IgE antibodies. S. ratti is readily maintained in laboratory rats (27), and it may represent the most practical source of antigens for most clinical applications of these serologic tests.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic implications of parasite-specific immune responses in immunocompromised patients with strongyloidiasis

Genta¹,

Douce²,

Walzer³

1986

J Clin Microbiol

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Parasite-specific humoral and cellular immune responses were evaluated in nine immunosuppressed patients with Strongyloides stercoralis infection. Four patients had the disseminated form of the disease, and five had serious manifestations without evidence of hyperinfection. All patients had high levels of immunoglobulin G (IgG) antibodies directed against S. stercoralis larval antigens as detected by the enzyme-linked immunosorbent assay. Seven patients had both elevated total serum IgE and parasite-specific IgE antibodies detected by a modified radioimmunoassay. The hyperinfected patients differed significantly from the nonhyperinfected group hi total and specific IgE levels and peripheral eosinophilia but not in specific IgG levels. None of the patients tested exhibited significant in vitro lymphoproliferative responses to parasite antigens. Our results indicated that the possibility of a protective role of IgE and eosinophils in strongyloidiasis deserves further investigation. In addition, we suggest that the enzyme-linked immunosorbent assay for specific IgG antibodies may have an important place in the diagnosis of strongyloidiasis in immunocompetent as well as in immunocompromised patients.

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“…Cette agression traduit la persistance d'une migration larvaire soulignée par Jarrett et Urquhart (1968), Moqbel et Denham (1977) et particulièrement étudiée par Taliaferro et Sarles (1939) avec N. muris. Parmi les résultats publiés par ces derniers auteurs, nous retenons ceux correspondant à une infestation et à une réin-festation selon des modalités qui se rapprochent le plus des conditions expérimentales dans lesquelles nous nous sommes placés : réinfestation par 5 000 larves, 6 à 8 semaines après 3 infestations à 3 jours d'intervalle par 5 000 larves.…”

Section: Discussionunclassified

La réaction corticosurrénale lors d’une tentative de réinfestation des rats par Strongyloides ratti

Bailenger

Chanraud

Cabannes

1981

Ann. Parasitol. Hum. Comp.

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RÉSUMÉ. Les tentatives de réinfestation, effectuées après la guérison spontanée d'un parasitisme par Strongyloides ratti, ne réussissent pas à établir une nouvelle génération d'adultes lorsque la contamination primaire est réalisé par 5 000 ou 10 000 larves, à plusieurs reprises ou en une seule fois, et que la période de repos entre le déparasitage et la contamination secondaire est limitée à 3 semaines. La réinfestation commence à devenir possible après un repos de 51 jours suivant la guérison d'une infestation primaire par 15 000 larves.Mais, bien qu'elles n'atteignent pas l'état adulte, les larves infestantes commencent leur migration tissulaire et provoquent une hypersécrétion de gluco-cortico-stéroïdes. Il existe donc une opposition entre la facilité avec laquelle l'organisme empêche, précocement et avec persistance, la transformation des larves en adultes et la difficulté qu'il éprouve à neutraliser les larves et à les empêcher de déclencher une agression.Cortico-adrenal reaction in rats to attempts of reinfestation by Strongyloides ratti. SUMMARY. After spontaneous recovery from infestation by Strongyloides ratti, reinfestationby a new generation of adult parasites is not possible if the primary infestation was by 5,000 or 10,000 larvae administered in one or more contacts and if the secondary infestation takes place 3 weeks after. Reinfestation becomes possible again 51 days after recovery from a primary infes tation by 15,000 larvae.However although the larvae do not reach the adult stage, they do begin their migration and cause hypersecretion of gluco-cortico-steroids. There is thus a contrast between the ease with which the organism rapidly and lastingly prevents the transformation of larvae into adults and the difficulty in neutralising the larvae and preventing them from triggering a stress.Dans une étude sur les variations de l'hypercorticostéronémie réactionnelle lors d'infestations répétées du Rat, par Strongyloides ratti (1980) nous avons montré que l'organism e, au sein duquel l'évolution du parasite est en cours, réagit à l'agression de nouvelles larves par une hypercorticostéronémie, malgré qu'il ne leur permette

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Strongyloides ratti: 1. Parasitological observations on primary and secondary infections in the small intestine of rats

Cited by 35 publications

References 17 publications

Immunity to Strongyloides ratti in rats. 1. Adoptive transfer with mesenteric lymph node cells

Immunity to Strongyloides ratti in rats. 1. Adoptive transfer with mesenteric lymph node cells

Diagnostic implications of parasite-specific immune responses in immunocompromised patients with strongyloidiasis

La réaction corticosurrénale lors d’une tentative de réinfestation des rats par Strongyloides ratti

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