Immunity to histomoniasis in turkeys following treatment with dimetridazole

Joyner, L. P.

doi:10.1016/s0368-1742(63)80023-5

Cited by 12 publications

(2 citation statements)

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“…Because infection with Histomonas meleagridis does not usually spread through a flock within a short time, birds may be uninfected or else in various stages of disease development at the time that the infection in a flock is diagnosed. Following effective therapy only those birds treated in advanced stages of disease have any immunity (Joyner, 1963) and, therefore, because of relapse, or reinfection, it is necessary to follow therapy by preventive medication. The results now reported together with those of other workers (McGuire, Moellar and Morehouse (1963), Condren et al (1963), Lucas (1963), Colvin et al (1963), show that in such cases where preventive medication is required, dimetridazole may be used at any stage of growth or reproduction.…”

Section: Discussionmentioning

confidence: 99%

Dimetridazole

Lucas

Owers

Scott

1967

British Poultry Science

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Section: Discussionmentioning

confidence: 99%

Dimetridazole

Lucas

Owers

Scott

1967

British Poultry Science

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“…Caused by the protozoan parasite Histomonas meleagridis , mortality can approach 80 to 100% of the flock with significant economic damage incurred ( Callait et al., 2002 , McDougald, 2005 , Hess and McDougald, 2013 ). Nitroimidazoles were previously an effective treatment for histomoniasis; however, regulatory action resulted in the removal of effective prophylactic and therapeutic compounds without any alternatives introduced for disease treatment ( Joyner, 1963 , Hess and McDougald, 2013 , Liebhart et al., 2013 ). Nitarsone, the last remaining Food and Drug Administration approved drug for the treatment of histomoniasis, was removed from the market in 2015 ( Regmi et al., 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Research Note: Evaluation of deoxycholic acid for antihistomonal activity

et al. 2020

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Deoxycholic acid ( DCA ) is a naturally occurring secondary bile acid that originates from intestinal bacterial metabolic conversion of cholate, a primary bile acid. Deoxycholic acid was shown to have antihistomonal properties in vitro, leading to our hypothesis that DCA inclusion within the feed might prevent histomoniasis. Selected dietary concentrations of DCA were evaluated for effects on body weight gain ( BWG ), lesions, and mortality of turkeys challenged with wild-type Histomonas meleagridis ( WTH ). Treatments consisted of non-challenged control ( NC ; basal diet), 0.25% DCA diet + challenge, 0.5% DCA diet + challenge, 1% DCA diet + challenge, and a positive-challenged control ( PC ; basal diet). All groups were fed a basal starter diet until day 7, at which time DCA diets were administered to the respective groups. On day 14, 2 × 10 5 WTH cells/turkey were intracloacally administered. H. meleagridis -related lesions were evaluated on day 13 post-challenge. Pre-challenge day 0 to 14 BWG was higher ( P ≤ 0.05) in the 0.25% DCA group than in the 1% DCA group. There were no significant differences in pre-challenge day 0 to 14 BWG between any of the other groups. No significant differences in mortalities from histomoniasis occurred in the DCA groups as compared to the PC group. No H. meleagridis lesions or mortalities were observed at any time in the NC group. Presence of H. meleagridis -related liver lesions was higher ( P ≤ 0.05) in the 0.5% DCA group as compared to the PC group. Using the same controls and experimental timeline, an additional group was included to evaluate a biliogenic diet formulated with 20% whole egg powder to encourage endogenous bile acid production. The biliogenic diet had no statistical impact on pre-challenge day 0 to 14 BWG, but did not reduce H. meleagridis -related mortalities or lesions after the challenge. Taken together, these data suggest that DCA inclusion within the feed at these concentrations and under these experimental conditions does not prevent histomoniasis.

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Etiology and dissemination of the blackhead disease syndrome in turkeys and chickens

Wm¹

1967

Experimental Parasitology

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Immunity to histomoniasis in turkeys following treatment with dimetridazole

Cited by 12 publications

References 5 publications

Dimetridazole

Dimetridazole

Research Note: Evaluation of deoxycholic acid for antihistomonal activity

Etiology and dissemination of the blackhead disease syndrome in turkeys and chickens

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