Immunity to Haemonchus contortus and Vaccine Development

Nisbet, Alasdair J.; Meeusen, Elza Nicole Theresia; González, J.; Piedrafita, David

doi:10.1016/bs.apar.2016.02.011

Cited by 95 publications

(84 citation statements)

References 156 publications

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“…The interaction between the different stages of H contortus and sheep is a complex phenomenon in which several components of the immune response seem to be implicated (reviewed in ). Generally, these components have been identified because their number/levels increase while the immune response is developing and through correlation studies with parasitological variables.…”

Section: Discussionmentioning

confidence: 99%

“…Haemonchus contortus is a geographically widespread haematophagous parasite, infecting the abomasum and causing significant production losses in sheep. In general, sheep can develop resistance with repeated infection and eosinophils are implicated as a major resistance mechanism . In vitro assays have demonstrated that eosinophils can inhibit the motility of L3 larvae with visible lesions appearing in the cuticle of the L3 and reduced infectivity .…”

Section: Introductionmentioning

confidence: 99%

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Increased susceptibility to Haemonchus contortus infection by interleukin‐5 modulation of eosinophil responses in sheep

Hernández

Meeusen

Rodrı́guez

et al. 2019

Parasite Immunology

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Eosinophils are prominent effector cells in immune responses against gastrointestinal nematode infections in ruminants, but their in vivo role has been hard to establish in large animals. Interleukin‐5 is a key cytokine in the induction and stimulation of anti‐parasitic eosinophil responses. This study attempted to modulate the eosinophil response in sheep through vaccination with recombinant interleukin‐5 (rIL‐5) and determine the effect on subsequent Haemonchus contortus infection. Nematode‐resistant Canaria Hair Breed (CHB) sheep vaccinated with rIL‐5 in Quil‐A adjuvant, had lower blood eosinophil counts and higher mean worm burdens than control sheep vaccinated with Quil‐A adjuvant alone. In addition, adult worms in IL‐5‐vaccinated sheep were significantly longer with higher eggs in utero in female worms, supporting an active role of eosinophils against adult parasites in CHB sheep. These results confirm that eosinophils can play a direct role in effective control of H contortus infection in sheep and offer a new approach to study immune responses in ruminants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased susceptibility to Haemonchus contortus infection by interleukin‐5 modulation of eosinophil responses in sheep

Hernández

Meeusen

Rodrı́guez

et al. 2019

Parasite Immunology

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“…An H contortus vaccine based on a worm gut membrane antigen mixture was recently commercialized for sheep (Barbervax, Wirevax) and has quickly become an invaluable tool to control haemonchosis in areas where anthelmintic resistance is rampant. 10 The vaccine is only registered in Australia and South Africa, but it can be used in the United Kingdom under Special Treatment Certificate and veterinary prescription. Vaccination with the vaccine also conferred protection against Haemonchus placei in grazing calves, 11 but the vaccine has not been registered for use in cattle.…”

Section: Haemonchus Contortusmentioning

confidence: 99%

“…Many efforts have been made to identify and express a range of antigens from H contortus, but most recombinant proteins were unsuccessful in eliciting protective immunity. 2,10 Recently, a gene encoding an Hc23 somatic antigen was identified and expressed in Escherichia coli. Lambs vaccinated with the recombinant Hc23 antigen were significantly protected against an artificial challenge infection, with more than 80% reduction in fecal egg counts (FECs) and average abomasal parasite burdens, compared with challenge controls.…”

Section: Haemonchus Contortusmentioning

confidence: 99%

Helminth Vaccines in Ruminants

Claerebout

Geldhof

2020

Veterinary Clinics of North America: Food Animal Practice

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KEYWORDS Gastrointestinal nematodes Lungworm Liver fluke Vaccines KEY POINTSOnly a few vaccines against parasitic helminths of livestock are currently on the market; namely those against Dictyocaulus viviparus in cattle, Haemonchus contortus in sheep, and the tapeworm Echinococcus granulosus in sheep.Research is ongoing to develop vaccines based on purified or recombinantly expressed worm proteins for Ostertagia ostertagi and Cooperia oncophora in cattle, for Teladorsagia circumcincta and H contortus in sheep, and for Fasciola hepatica in ruminants. Recombinant expression of worm antigens with the correct conformation to induce protective immunity is still a major challenge in vaccine development. Vaccination is likely to be part of integrated worm control, together with other control measures, such as anthelmintic treatments, biological control, and grazing management. Interdisciplinary research, including social sciences, should investigate drivers of farmers' and veterinarians' decision making, to optimize uptake of vaccination by the end users.Vet Clin Food Anim 36 (2020) 159-171

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“…Blood feeding by H. contortus results in haemorrhagic gastritis, oedema, diarrhoea and death in severe infections, leading to significant economic impact through decreased livestock production (Mavrot et al 2015;McLeod 1995;Roeber et al 2013). Sheep can develop effective immunity to H. contortus infection and vaccine-induced protection using H. contortus-derived molecules has been demonstrated, suggesting that the control of this parasite through vaccination is possible (Nisbet et al 2016). However what host molecules recognise these glycoproteins are poorly understood.…”

Section: Ietroductioementioning

confidence: 99%

Proteomic identification of Galectin-11 and 14 ligands from Haemonchus contortus

Sakthivel

Swan

Preston

et al. 2017

Preprint

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Haemonchus contortus is the most pathogenic nematode of small ruminants. Infection in sheep and goats results in anaemia that decreases animal productivity and can ultimately cause death. The involvement of ruminant-specific galectin-11 (LGALS-11) and galectin-14 (LGALS-14) has been postulated to play important roles in protective immune responses against parasitic infection; however, their ligands are unknown. In the current study,LGALS-11 and LGALS-14 ligands in H. contortus were identified from larval (L4) and adult parasitic stages extracts using immobilised LGALS-11 and LGALS-14 affinity column chromatography and mass spectrometry. AbstractHaemonchus contortus is the most pathogenic nematode of small ruminants. Infection in sheep and goats results in anaemia that decreases animal productivity and can ultimately cause death.The involvement of ruminant-specific galectin-11 (LGALS-11) and galectin-14 (LGALS-14) has been postulated to play important roles in protective immune responses against parasitic infection; however, their ligands are unknown. In the current study, ligands in H. contortus were identified from larval (L4) and adult parasitic stages extracts using immobilised LGALS-11 and LGALS-14 affinity column chromatography and mass spectrometry.

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Immunity to Haemonchus contortus and Vaccine Development

Cited by 95 publications

References 156 publications

Increased susceptibility to Haemonchus contortus infection by interleukin‐5 modulation of eosinophil responses in sheep

Increased susceptibility to Haemonchus contortus infection by interleukin‐5 modulation of eosinophil responses in sheep

Helminth Vaccines in Ruminants

Proteomic identification of Galectin-11 and 14 ligands from Haemonchus contortus

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