Immunity in human schistosomiasis mansoni: Cross-reactive IgM and IgG2 anti-carbohydrate antibodies block the expression of immunity

Butterworth, Anthony E.; Dunne, David W.; Fulford, Anthony J. C.; Capron, Moníque; Khalife, Jamal; Càpron, André; Koech, Davy K.; Ouma, John H.; Sturrock, R. F.

doi:10.1016/0300-9084(88)90268-4

Cited by 82 publications

(83 citation statements)

References 22 publications

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“…It is now generally accepted that in areas endemic for human schistosomiasis an age-dependent immunity occurs, so that after Clin Exp Immunol 1996; 106:45-54 chemotherapeutic treatment young children are highly susceptible to reinfection, whereas older individuals, who are equally exposed to infection, are resistant [1][2][3]. Within endemic areas, infected individuals of all ages have high levels of circulating antibody with anti-schistosome specificity, including antibodies which react with the surface of the schistosomulum.…”

Section: Introductionmentioning

confidence: 99%

Specific immunoglobulin measurements related to exposure and resistance to Schistosoma mansoni infection in Sudanese canal cleaners

Satti

Lind

Vennervald

et al. 1996

Clinical and Experimental Immunology

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SUMMARYThe present work comprises a longitudinal study of Schistosoma mansoni infection in occupationally hyper-exposed canal cleaners in the Sudan and the influence of chemotherapy on humoral immune parameters. The study groups included chronically infected canal cleaners (n = 19), newly recruited canal cleaners (n 17), normally exposed adults (n 31), school children (n 46) and Sudanese negative controls (n 48). Previous studies of the same canal cleaners have demonstrated that chronically infected canal cleaners were more resistant to reinfection than newly recruited canal cleaners. ELISA was used to detect specific IgE and IgG subclasses in response to whole worm antigen (WWH) and soluble egg antigen (SEA) before and 3 months after praziquantel treatment in the groups of canal cleaners and before and 1 year after treatment in normally exposed adults. When intensity of infection was correlated with IgE antibody response, the resistant group of canal cleaners (those who stopped passing ova after treatment) showed a significant positive correlation between intensity of infection and specific IgE to WWH (Spearman's correlation coefficient 01). Normally exposed adults and school children had significantly less specific IgE to WWH than canal cleaners, while chronically infected canal cleaners had significantly higher levels of specific IgG1 to WWH than newly recruited canal cleaners and school children, and significantly higher levels of specific IgG4 to WWH than school children. There was a significant increase in specific IgG1 and IgG4 to WWH, 3 months after treatment, in newly recruited canal cleaners and a significant decrease, 1 year after treatment, in normally exposed adults. None of the groups studied after treatment showed a significant change in their specific IgE to WWH. Normally exposed adults had significantly lower levels of specific IgE to SEA than newly recruited canal cleaners, and significantly lower levels of specific IgG1 to SEA than other infected groups. Both newly recruited canal cleaners and school children had significantly higher levels of specific IgG2 to SEA than persons in other groups. Only small differences between groups were observed with regard to specific IgG3 and IgM to SEA. Specific IgG4 to WWH and SEA showed different patterns after treatment between the resistant and susceptible groups of canal cleaners. The resistant group maintained the same level of IgG4 to WWH after treatment compared with a significant increase in the susceptible group. On the other hand, levels of specific IgG4 to SEA showed a highly significant decrease after treatment in the resistant group. In contrast, the same antibody subclass increased after treatment in the susceptible group. Generally, results show an association between IgE and IgG1 responses to WWH and resistance to reinfection. In contrast, an association was observed between IgG2 and IgM responses to SEA and susceptibility to reinfection.

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Section: Introductionmentioning

confidence: 99%

Specific immunoglobulin measurements related to exposure and resistance to Schistosoma mansoni infection in Sudanese canal cleaners

Satti

Lind

Vennervald

et al. 1996

Clinical and Experimental Immunology

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“…The role of the cellular and humoral immune response against Schistosoma mansoni infection has been well characterized by several laboratories (Colley et al 1977, Mendlovic et al 1987, Aldrey et al 1988, Benarroch et al 1988, Butterworth et al 1988. Hypergammaglobulinemia is a common feature of this response, with consistently elevated total serum IgG (mainly IgG 1 and IgG 4 ) and IgE concentrations in untreated, chronically infected individuals (Iskander et al 1981, Jassim et al 1987, Evengard et al 1988, Boctor & Peter 1990).…”

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confidence: 99%

The immunopathology of human schistosomiasis-III: immunoglobulin isotype profiles and response to praziquantel

Ramirez

Ceballos

Noya

et al. 1996

Mem. Inst. Oswaldo Cruz

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“…the only significant interactions were for IgE and IgM. The fact that an S. haematobium infection affects immune responses to S. mansoni antigens is largely due to shared/ cross-reactive antigens between S.mansoni and S. haematobium for example the carbohydrate epitopes which induce the IgM response (Butterworth et al 1988).…”

Section: Discussionmentioning

confidence: 97%

“…One such pattern is the distribution of immune responses across different ages in a host population. For both Schistosoma mansoni and S. haematobium responses directed against egg antigen, levels of IgE have been shown to increase with age, those of IgA, IgM and IgG2 have been shown to decrease with age, while levels of IgG1 and IgG3 have been shown to either increase or decrease (Demeure et al 1983, Butterworth et al 1988, Hagan et al 1991, Dunne et al 1992a,b, Grogan et al 1996, Ndhlovu et al 1996, Mutapi et al 1997, Webster et al 1997. The explanations for these patterns have been controversial.…”

mentioning

confidence: 99%

The effect of treatment on the age-antibody relationship in children infected with Schistosoma mansoni and Schistosoma haematobium

Mutapi

Mduluza

Ndhlovu

2002

Mem. Inst. Oswaldo Cruz

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Immunity in human schistosomiasis mansoni: Cross-reactive IgM and IgG2 anti-carbohydrate antibodies block the expression of immunity

Cited by 82 publications

References 22 publications

Specific immunoglobulin measurements related to exposure and resistance to Schistosoma mansoni infection in Sudanese canal cleaners

Specific immunoglobulin measurements related to exposure and resistance to Schistosoma mansoni infection in Sudanese canal cleaners

The immunopathology of human schistosomiasis-III: immunoglobulin isotype profiles and response to praziquantel

The effect of treatment on the age-antibody relationship in children infected with Schistosoma mansoni and Schistosoma haematobium

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