The effect of treatment on the age-antibody relationship in children infected with Schistosoma mansoni and Schistosoma haematobium

Mutapi, Francisca; Mduluza, Takafira; Ndhlovu, Patricia D.

doi:10.1590/s0074-02762002000900034

Cited by 3 publications

(5 citation statements)

References 27 publications

(31 reference statements)

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“…Several studies of infection and reinfection with Schistosoma mansoni after treatments with PZQ of residents living in endemic areas have shown that after treatment, prevalence and intensity of parasite infestation due to re-infection are lower than before treatment. In other words, the re-infection prevalence and intensity have been shown never to equal before treatment level (5,7). In this cohort study to establish regiments for PZQ treatment against S. mansoni among the residents of Kigungu, showed that there was reduction in the percentage of infection from 47.4% (448 / 945) to 25.8% (80 /310) and eggs excretion was reduced by 92.7% .…”

Section: Discussionmentioning

confidence: 88%

“…In addition, Correa-Oliveira in their natural versus drug induced resistance in S. mansoni infections study followed their patients for five years at an interval of one year (7). Repeated treatment with PZQ within short intervals was also found to have no effect on the re-infection period in children in their first decade of life (7). Nevertheless, the cure proportion of PZQ is greater if the treatment is repeated within a short period but the cost of the treatment remains relatively high (6,10).…”

Section: Discussionmentioning

confidence: 99%

“…This was to find out the level of resistance and susceptibility developed after treatment. Follow up studies to establish the force of reinfection after treatment with PZQ after short interval is well known, (5,7,8). Schistosomiasis control Programmes notably Uganda and in other Tropical countries are based on the single dose administration of PZQ to large communities.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies in Uganda and elsewhere revaluated the efficacy of PZQ after six months to establish the cure proportion (4,5). Nevertheless other studies revaluated the efficacy of PZQ at the interval of one year for a longer period (6,7). At present, studies in different endemic settings using the single oral dose regiment of 40 (mg/kg wt) of PZQ against S. mansoni, S. haematobium and mixed infections, the efficacy of PZQ is reported to stand at 60-90 % (8).…”

Section: Introductionmentioning

confidence: 99%

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Evidence of Long Term Benefit of Praziquantel Treatment Against Schistosoma mansoni in Kigungu Fishing Village of Entebbe, Uganda

Odongo-Aginya¹,

Kironde²,

Lyazi³

et al. 2012

Af J Clin Exp Micro

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Praziquantel (PZQ) is efficacious against all species of schistosome: Schistosoma mansoni; Schistosoma haematobium; Schistosoma japonicum and other parasites like the Taenia species. This cross-sectional cohorts study was carried out in Kigungu fishing village along Lake Victoria shore in Entebbe Uganda. Our analysis was based on examining microscopically three slides from a single stool specimen from each of base line cohorts 945.These included children and adults, participants from both sexes in Kigungu fishing village in Entebbe Uganda. Nine hundred and one (901) of the cohorts were reexamined after six months and 625 of the same cohorts who were examined at the baseline and after six months were reexamined 18 months later. The slides were prepared using modified Kato/Katz (Odongo-Aginya) method. The infection proportion with Schistosoma mansoni at baseline was 448 (47.5%) but this was reduced to 244 (25.8%) 18 months after treatment with a single oral dose of praziquantel at 40mg/kg. However 495 (52.5%) were negative at the baseline study. The cure proportion after six was significant {(P=0.00), (OR4.63) CI at 95% (3.53-6.06)}. Similarly the cure proportion after 18 months was significant {(P=0.00), (OR2.2) CI at 95% (1.87-3.34)}. The force of re-infection after six months was significant {(P=0.0001), (OR 0.47) CI at 95% (0.31-0.71)}. Nevertheless the force of re-infection was not significant after 18 months {(P=0.766), (OR 0.95) CI at 95% (0.68-1.34)} eggs excretion did not reach the level of the pre-treatment intensity. The egg reduction was 69.3%. This was associated with age and pre-treatment intensity < 400 eggs per gram (epg) of faeces and age groups ≥ 30 years. The egg reduction also resulted in marked decrease in clinical symptoms in the participants. Our study suggests evidence of long-term benefit of praziquantel in Kigungu and that the re-infection occurred more commonly in younger age group than in the older patients.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evidence of Long Term Benefit of Praziquantel Treatment Against Schistosoma mansoni in Kigungu Fishing Village of Entebbe, Uganda

Odongo-Aginya¹,

Kironde²,

Lyazi³

et al. 2012

Af J Clin Exp Micro

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“…Mutapi in their study of changes in specific anti-egg antibody levels with PZQ followed their patients after 9 months ( Mutapi, et al, 1998 ). In addition, Correa-Oliveira in their natural versus drug induced resistance in S. mansoni infections study followed their patients for five years at an interval of one year ( Correa-Oliveira, et al, 2000 ).…”

Section: Discussionmentioning

confidence: 99%

Evidence of long term benefit of morbidity reduction due to praziquantel treatment against Schistosoma mansoni in Kigungu fishing village in Entebbe, Uganda

Odongo-Aginya¹,

Kironde²,

Lyazi³

et al. 2011

African Journal of Infectious Diseases

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Praziquantel (PZQ) is efficacious against Schistosoma mansoni. This was prospective cohort study. This study was carried out at Kigungu fishing village, Entebbe, Uganda. The goal of the study was to establish cost effective regiment for mass drug administration (MDA) of Praziquentel in the morbidity reduction of S.mansoni infection. In January 2004, nine hundred and forty five (945) participants were registered in this study. Our analysis was based on examining microscopically three slides prepared from each of 945 stool specimens delivered by each of the participant using modified Kato/Katz method. These included male and female, children and adults living in Kigungu fishing village in Entebbe Uganda. In total 901, cohorts were re-examined for infections clearance six months later in July 2004 and 18 months later in June 2005, 625 cohorts were again re-evaluated for S.mansoni infections after the baseline study. At baseline, (448) of 945 (47.5%) cohorts were S. mansoni positive. All these participants were treatment with a single oral dose of praziquantel at 40mg/kg. At the same time, 495 (52.5%) were S. mansoni negative. Of the 625 (66.3%) cohorts who came back for final review, 80 (12.8%) were still positive for S. mansoni while 210 (33.6%) remained negative after the base line treatment with praziquantel. On the other hand 103 (16.3%) of cohorts who were initially negative at the base line became S.mansoni positive after 18 months and 213(34.1%) remained negative for S.mansoni. The force of re-infection after six months was significant {(P=0.0001), (OR 0.47) CI at 95% (0.31–0.71)}. Nevertheless the force of reinfection was not significant after 18 months {(P=0.766), (OR 0.95) CI at 95% (0.68–1.34)}.The geometric mean eggs excretion of the 80 cohorts who were S.mansoni positive at 18 months was 151.967.This did not reach the geometric mean egg excreted by the same cohorts at baseline which was 285.05. The egg excretion was reduced by 46.8%. Similarly there was marked decrease in clinical symptoms amongst the cohorts. Our study suggests evidence of long-term benefit of praziquantel in Kigungu and that a yearly administration of praziquantel to the community could be a regiment for mass drug administration (MAD) for this community to control schistosomiasis morbidity.

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Der Einfluß von Mikronährstoffen auf die Therapie und die Reinfektion der durch Schistosoma haematobium hervorgerufenen Bilharziose bei tansanischen Kindern

Kaul¹

2006

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The effect of treatment on the age-antibody relationship in children infected with Schistosoma mansoni and Schistosoma haematobium

Cited by 3 publications

References 27 publications

Evidence of Long Term Benefit of Praziquantel Treatment Against <i>Schistosoma mansoni</i> in Kigungu Fishing Village of Entebbe, Uganda

Evidence of Long Term Benefit of Praziquantel Treatment Against <i>Schistosoma mansoni</i> in Kigungu Fishing Village of Entebbe, Uganda

Evidence of long term benefit of morbidity reduction due to praziquantel treatment against <i>Schistosoma mansoni</i> in Kigungu fishing village in Entebbe, Uganda

Der Einfluß von Mikronährstoffen auf die Therapie und die Reinfektion der durch Schistosoma haematobium hervorgerufenen Bilharziose bei tansanischen Kindern

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