Immunity and probiotics

Dugas, B.; Mercenier, Annick; Lenoir-Wijnkoop, Irène; Arnaud, C.; Dugas, Nathalie; Postaire, E.

doi:10.1016/s0167-5699(99)01448-6

Cited by 136 publications

(79 citation statements)

References 4 publications

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“…13,14) For instance, Fujiwara et al 15) reported that Lactobacillus paracasei strain KW3110 inhibited serum IgE elevation in the mouse allergy model. Strain L-55 used in this study had adherent ability to Caco-2 cells derived from human enteric epithelium.…”

Section: Discussionmentioning

confidence: 99%

Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice

Sunada¹,

Nakamura²,

Kamei

2007

Biological & Pharmaceutical Bulletin

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We investigated the effect of Lactobacillus acidophilus strain L-55 isolated from infant feces on experimental allergic rhinitis in BALB/c mice. The heat-treated cells of strain L-55 were orally administrated for 4 consecutive weeks to mice sensitized by ovalbumin (OVA), and nasal symptoms (sneezing and nasal rubbing) induced by OVA challenge were evaluated. Strain L-55 at doses of 1 and 10 mg cells/mouse significantly inhibited nasal symptoms by repeated administration over a period of 2 weeks. Furthermore, we measured the level of OVA-specific IgE titers in the serum by passive cutaneous anaphylaxis (PCA) reaction. PCA titers in the sera from mice administrated strain L-55 were significantly lowered compared with the control. These results suggest that oral administration of strain L-55 may be useful for alleviating the nasal symptoms of allergic rhinitis.

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Section: Discussionmentioning

confidence: 99%

Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice

Sunada¹,

Nakamura²,

Kamei

2007

Biological & Pharmaceutical Bulletin

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“…Gastrointestinal disorders where probiotics might be anticipated to have a therapeutic application include antibiotic-associated diarrhoea; bacterial overgrowth and other diarrhoeal syndromes; in ammatory bowel disease, and colonic cancer (1,12,36). Probiotics also offer the very real potential to deliver therapeutically relevant proteins including enzymes, vaccines and cytokines (37).…”

Section: Discussionmentioning

confidence: 99%

A Randomised Controlled Trial of a Probiotic Lactobacillus Strain in Healthy Adults: Assessment of its Delivery, Transit and Influence on Microbial Flora and Enteric Immunity

Collins

Dunne²,

Murphy³

et al. 2002

Microbial Ecology in Health and Disease

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In severa l intestinal disease states, altered micro ora, impaired gut barrier and:or intestinal in ammation offer a rationale for the effective therapeut ic use of probiotic microorganisms. However , for most candidat e probiotic organisms there is a lack of evidence detailing their characterisation and effects on host ora and immunity. We have previously reported the isolation and characterisation, from surgically resected segment s of the huma n gastrointestinal tract (GIT), of potential probiotic lactic acid bacteria (LAB). We have also described subsequen t animal experimen ts that evaluated the establishment , persistence and localisation of speci c probiotic Lactobacillus strains within the murine intestinal tract, in addition to their ability to in uence the developmen t of murine in ammatory disorders. In these studies, transit and surviva l of Lactobacillus salivarius U CC118 at the ileum was demonstrat ed using enteral tube sampling of six healthy volunteer s following consumption of a single dose (150 ml) of fermented milk-born e probiotic (10 8 colony forming units per ml (CF U :ml)). Subsequently, we performed a randomised controlled trial of 80 volunteer s fed strain UCC118 (10 8 CF U:day for 21 d), using two oral delivery vehicles (fresh milk, n ¾ 20 vs. fermented milk, n ¾ 20; controls, n ¾ 20 for each). Throughout this feeding period , and for up to 100 days following cessation of feeding, the number s of total culturable lactobacilli and of the administered Lactobacillus U CC118 present in faeces were monitored. F ive subjects (5:40; fresh milk, four; fermented milk, one) were still excretin g the probiotic lactobacilli 21 days post-cessatio n of feeding, while one subject (fermented milk) was still colonised up to 100 days after feeding. Consumpt ion of fermented milk-born e UCC118 cells resulted in signi cantly increased levels of faecal-borne enterococci and lactobacilli. N umber s of bi dobacteria, coliforms and bacteroides were not signi cantly altered. In addition, changes in salivary IgA levels against U CC118 cells and increased granulocyt e phagocytic activity were observed following consumption of the fermented milk-borne probiotic. In summary, Lactobacillus UCC118 was found to effectively transit (and persist within) the human intestinal tract, to modify the faeca l ora and to engage the immune system.

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“…Probiotics can be defined as nonpathogenic microorganisms which when ingested play a key role in human nutrition and health in balancing the intestinal microflora naturally. These living bacteria can influence the human in many aspect (Dugas et al, 1999;Isolauri et al, 2001;Marteau et al, 2001). It has been shown that when probiotics supplemented early enteral nutrition they reduced the septic complications in acute pancreatitis (Dugas et al, 1999;Oláh et al, 2002a, b).…”

Section: Introductionmentioning

confidence: 99%

“…These living bacteria can influence the human in many aspect (Dugas et al, 1999;Isolauri et al, 2001;Marteau et al, 2001). It has been shown that when probiotics supplemented early enteral nutrition they reduced the septic complications in acute pancreatitis (Dugas et al, 1999;Oláh et al, 2002a, b). Several advantages of enteral feeding over parenteral feeding have been demonstrated but no experimental study has documented the histopathologic effects of probiotics in acute pancreatitis (Sahin et al, 1999;Qin et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Effects of probiotics on the severity of experimental acute pancreatitis

et al. 2005

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Objective: This study was designed to evaluate the effects of probiotics on the severity of experimental acute pancreatitis. Design: Experimental study. Setting: Experiments were done in a laboratory at Haydarpasa Numune Teaching and Research Hospital. Subjects:A total of 50 Wistar rats were randomly divided into five groups. Interventions: Group 1 was control group. Group 2 received an intraperitoneal injection of a 20% solution in 0.15 mol/l NaCL. Group 3 was injected NaCL and fed with probiotics. Acute pancreatitis was induced in rats by intrperitoneal injection of L-Arginine in groups 4 and 5. The rats in group 5 were treated with probiotics. The pancreas was removed for histologic examination. Evaluation of the pathologic changes was done by a new combined histopathologic grading scale. Results: The mean scores of fibrosis, acinar cell loss, oedema, parenchymal necrosis, mononuclear cells infiltration, polymorphonuclear leucocytes infiltration, ductal damage and atypical reactive regeneration in group 5 were significantly lower than group 4. Conclusions: We demonstrated that enteral feedings with added probiotics can reduce the severity of acute pancreatitis. Sponsorship: None.

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Immunity and probiotics

Cited by 136 publications

References 4 publications

Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice

Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice

A Randomised Controlled Trial of a Probiotic Lactobacillus Strain in Healthy Adults: Assessment of its Delivery, Transit and Influence on Microbial Flora and Enteric Immunity

Effects of probiotics on the severity of experimental acute pancreatitis

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