2014
DOI: 10.1017/s0022215114001431
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Immunisations and antibiotics in patients with anterior skull base cerebrospinal fluid leaks

Abstract: There is no evidence to support the use of antibiotic prophylaxis in patients with a cerebrospinal fluid leak. We propose that all such patients are advised to seek immunisation against pneumococcus, meningococcus and haemophilus.

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Cited by 10 publications
(8 citation statements)
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“…Choi and Spann studied 1 retrospective cohort that identified a higher incidence of meningitis in patients with basilar skull fractures who received prophylactic antibiotics (12/197) vs those who did not have antibiotics (0/73). Although Rimmer et al . acknowledged that there is a lack of evidence to support prophylactic antibiotics in patients with a CSF leak, they proposed that all patients with an anterior skull base CSF leak at least be immunized against pneumococcus, meningococcus, and haemophilus.…”
Section: Primary Csf Rhinorrheamentioning
confidence: 99%
“…Choi and Spann studied 1 retrospective cohort that identified a higher incidence of meningitis in patients with basilar skull fractures who received prophylactic antibiotics (12/197) vs those who did not have antibiotics (0/73). Although Rimmer et al . acknowledged that there is a lack of evidence to support prophylactic antibiotics in patients with a CSF leak, they proposed that all patients with an anterior skull base CSF leak at least be immunized against pneumococcus, meningococcus, and haemophilus.…”
Section: Primary Csf Rhinorrheamentioning
confidence: 99%
“…Größere Erfahrungen liegen bisher jedoch nicht vor [723,724]. Es wurde aktuell zusätzlich zur endoskopischen Duraplastik empfohlen, Patienten mit einer Meningitis bei vermuteter oder nachgewiesener Duraläsion unverzüglich gegen die häufigsten relevanten bakteriellen Erreger (Pneumokokken, Meningokokken, Hämophilus influenzae) impfen zu lassen [168], wobei die Pneumokokkenimpfung die wichtigste darstellt und laut offiziellen Empfehlungen der STIKO bei Liquorfistel indiziert ist (http://www.rki.de/DE/Content/Kommissionen/STIKO/Empfehlungen/Impfempfehlungen_node.html). Nach einer Nasennebenhöhlenoperation sind starke und/oder anhaltende Kopfschmerzen, auch schon am Operationstag, verdächtig hinsichtlich einer Duraläsion und intrakraniellen Komplikation.…”
Section: Duraplastikunclassified
“…einer Woche erreicht [765]. Während eine Antibiotikaprophylaxe bei unkomplizierter Rhinoliquorrhoe/Duraläsion nicht indiziert ist [167,168], wird eine perioperative Antibiotikagabe im Rahmen der Duraplastik allgemein empfohlen. Sie erfolgt solange Nasentamponaden oder eine Lumbaldrainage in situ sind und sollte ausreichend gegen Staphylokokkus aureus wirken [162,164,165].…”
Section: Duraplastikunclassified
“…The relative importance of antibiotic prophylaxis as well as the selection of the "true" high-risk candidates remain to be defined. 89 However, the Center for Disease Control and Prevention recommends either the pneumococcal conjugate vaccine (PCV13) or the pneumococcal polysaccharide vaccine (PPSV23) for patients with CSF leaks. 90…”
Section: Post-traumatic Csf Leaksmentioning
confidence: 99%