Immune thrombocytopenia in a child with COVID‐19: Is it the calm after the (cytokine) storm?

Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database

“…The decrease in the number of leukocytes impairs the defence of the body by depriving it of specialized immune cells. Leukopenia has been reported in cases of coronavirus infection causing severe disease in humans, and less in common human coronaviruses, which cause common flu-like symptoms (43). In this study, most cases (48, 20.51%) and especially those in the age group above 12 years old presented leukopenia, which may be due to the presence of puberty (44).…”

Severe Thrombocytopenic Purpura Associated with COVID-19 in a Pediatric Patient

“…Immune thrombocytopenia (ITP) is a common acquired acute autoimmune bleeding disorder during childhood, characterized by isolated thrombocytopenia of <100×10 3 /μL, petechial rash, bruising and bleeding in an otherwise healthy child. 1 , 2 It affects approximately 1.9–6.4/100,000 children per year and is due to a loss of immunological tolerance to platelet membrane antigens, resulting into an increased platelet destruction coupled on occasion with impaired/inadequate platelet production. 1 , 3 Although the pathophysiology may not yet be entirely understood, it appears that autoantibodies related to commonly immunoglobulin G (IgG), are directed against platelet membrane antigens such as glycoprotein IIb/IIIa complex, glycoprotein Ib/IX, glycoprotein Ia/IIa and glycoprotein VI.…”

“… 1 , 2 It affects approximately 1.9–6.4/100,000 children per year and is due to a loss of immunological tolerance to platelet membrane antigens, resulting into an increased platelet destruction coupled on occasion with impaired/inadequate platelet production. 1 , 3 Although the pathophysiology may not yet be entirely understood, it appears that autoantibodies related to commonly immunoglobulin G (IgG), are directed against platelet membrane antigens such as glycoprotein IIb/IIIa complex, glycoprotein Ib/IX, glycoprotein Ia/IIa and glycoprotein VI. 4 ITP has been linked to vaccines, antiviral drugs but can also be triggered by silent or overt viral pathogens such as human immunodeficiency virus (HIV), cytomegalovirus, Epstein–Barr virus, parvovirus B19, adenovirus, varicella-zoster virus, hepatitis C and seasonal influenza.…”

COVID-19 İlişkili Akut İmmün Trombositopenik Purpura: Sıradışı Pediatrik Bir Olgu

“…Three weeks later, the patient was discharged and followed up in the outpatient clinic. It was reported that he was in optimal clinical condition and his complete blood count was normal in his nine-month follow-up (16).…”

“…Apart from the three pediatric cases mentioned in the systematic review, two more pediatric cases (fourth and fifth cases) were reported. The clinical features of these cases (16,17), treatments applied for ITP, and clinical follow-up information are given below.…”